The SARAF-LINAC Project for SARAF-PHASE 2

THPF005International audienceSNRC and CEA collaborate to the upgrade of theSARAF accelerator to 5 mA CW 40 MeV deuteron andproton beams (Phase 2). This paper presents the referencedesign of the SARAF-LINAC Project including a fourvane176 MHz RFQ, a MEBT and a superconducting linacmade of four five-meter cryomodules housing 26superconducting HWR cavities and 20 superconductingsolenoids. The first two identical cryomodules house lowbeta($\beta$opt = 0.091), 280 mm long (flange to flange), 176MHz HWR cavities, the two identical last cryomoduleshouse high-beta ($\beta$opt = 0.181), 410 mm long, 176 MHz,HWR cavities. The beam is focused with superconductingsolenoids located between cavities housing steering coils.A BPM is placed upstream each solenoid

On Averaging and Extrapolation for Gradient Descent

This work considers the effect of averaging, and more generally extrapolation, of the iterates of gradient descent in smooth convex optimization. After running the method, rather than reporting the final iterate, one can report either a convex combination of the iterates (averaging) or a generic combination of the iterates (extrapolation). For several common stepsize sequences, including recently developed accelerated periodically long stepsize schemes, we show averaging cannot improve gradient descent's worst-case performance and is, in fact, strictly worse than simply returning the last iterate. In contrast, we prove a conceptually simple and computationally cheap extrapolation scheme strictly improves the worst-case convergence rate: when initialized at the origin, reporting $(1+1/\sqrt{16N\log(N)})x_N$ rather than $x_N$ improves the best possible worst-case performance by the same amount as conducting $O(\sqrt{N/\log(N)})$ more gradient steps. Our analysis and characterizations of the best-possible convergence guarantees are computer-aided, using performance estimation problems. Numerically, we find similar (small) benefits from such simple extrapolation for a range of gradient methods.Comment: 25page

Electronic prescriptions: where medicine, computer security and e-commerce meet

A three tier secure enterprise system was developed for writing and transmitting prescription data over a computer network. Web browsers served as clients, with forms aimed at maximizing convenience and minimizing risk of human error. An Apache server running on Linux was used to respond to client browsers via the Secure Sockets Layer. The MySQL database manager was used for access to data on doctors, drugs, patients and prescriptions. Middle tier programming was done in duplicate in Java and Perl. The Jakarta Tomcat servlet container was used together with Apache for the Java version. When Perl scripts were used, the mod_Perl Apache module kept response times down by running them within Apache instead of starting up separate processes. There was no significant difference in the time taken for the Java servlets and Perl scripts to return responses. The Perl syntax was found to be easier for writing as well as reading code.California State University, Northridge. Department of Computer Science.Includes bibliographical references (leaves 60-61

Achieving Coordination Through Dynamic Construction of Open Workflows ** PLEASE SEE WUCSE-2009-14 **

Workflows, widely used on the Internet today, typically consist of a graph-like structure that defines the orchestration rules for executing a set of tasks, each of which is matched at run-rime to a corresponding service. The graph is static, specialized directories enable the discovery of services, and the wired infrastructure supports routing of results among tasks. In this paper we introduce a radically new paradigm for workflow construction and execution called open workflow. It is motivated by the growing reliance on wireless ad hoc networks in settings such as emergency response, field hospitals, and military operations. Open workflows facilitate goal-directed coordination among physically mobile agents (people and host devices) that form a transient community over an ad hoc wireless network. The quintessential feature of the open workflow paradigm is the ability to construct a custom context-specific workflow specification on the fly in response to unpredictable and evolving circumstances by exploiting the knowhow and services available within a given spatiotemporal context. This paper introduces the open workflow approach and explores the technical challenges (algorithms and architecture) associated with its first practical realization

Programación curricular para el desarrollo de las competencias del área de Matemática en estudiantes de tercer grado del nivel de primaria en una institución educativa pública de Andoas, Datem del Marañón, Loreto.

Este trabajo de suficiencia profesional está enfocado en una programación curricular dirigida al desarrollo de las competencias del área de matemáticas en estudiantes de tercer grado de educación primaria en una institución educativa pública ubicada en Andoas, Datem del Marañón, Loreto. Su objetivo principal es diseñar una propuesta didáctica que favorezca el desarrollo de las competencias matemáticas en los estudiantes de tercer grado del nivel primario. El trabajo está estructurado en varios capítulos: el primer capítulo describe el contexto situacional de la institución; el segundo presenta las contribuciones teóricas de Piaget, Vygotsky y Ausubel en relación con la propuesta planteada; y en el último capítulo, se expone la propuesta didáctica, que incluye la planificación anual, la unidad didáctica y las sesiones de aprendizaje. Además, se incluyen las conclusiones, recomendaciones y anexos.Juu takat nekas nuimiaru jismau takat umatin emtikiamu umismau nuimiati jeamuri nekapmati nuimin kampatam nuimiatin takaku yamtai, ñakmawai Andoanmanini Datennum achitkau.Nugka tesarrnayamu.jekatin nintirnramu kichik pusamu,takastin takat ematnun yaintin nekamuri nekapmatai,nuimin ainau kampatan musarchi takaku.ainau. Ju takatka mash kantramu untsuri nankamke:yamai nankamamuri aujmatui warukuita yamtaisha nuna pachis.nuniae. jimiaran chicha nuka chichawai Piaget,ygosky nunia Ausubel aujmattsamu pachis.irur juuk chichsmau; nunia inian namuri pujui urumdra takastinun,nunia awawai takat kichik musatch takastinum, kichik nantu takastinun, juniash jintiatin umismau nuniasha irumui inannamun ujamuri inannamu takasmau inakmawai.Trabajo de suficiencia profesiona

Wettability Modification of Nanomaterials by Low-Energy Electron Flux

Controllable modification of surface free energy and related properties (wettability, hygroscopicity, agglomeration, etc.) of powders allows both understanding of fine physical mechanism acting on nanoparticle surfaces and improvement of their key characteristics in a number of nanotechnology applications. In this work, we report on the method we developed for electron-induced surface energy and modification of basic, related properties of powders of quite different physical origins such as diamond and ZnO. The applied technique has afforded gradual tuning of the surface free energy, resulting in a wide range of wettability modulation. In ZnO nanomaterial, the wettability has been strongly modified, while for the diamond particles identical electron treatment leads to a weak variation of the same property. Detailed investigation into electron-modified wettability properties has been performed by the use of capillary rise method using a few probing liquids. Basic thermodynamic approaches have been applied to calculations of components of solid–liquid interaction energy. We show that defect-free, low-energy electron treatment technique strongly varies elementary interface interactions and may be used for the development of new technology in the field of nanomaterials

Stability and Release Kinetics of an Advanced Gliclazide-Cholic Acid Formulation: The Use of Artificial-Cell Microencapsulation in Slow Release Targeted Oral Delivery of Antidiabetics

Introduction: In previous studies carried out in our laboratory, a bile acid (BA) formulation exerted a hypoglycaemic effect in a rat model of type-1 diabetes (T1D). When the antidiabetic drug gliclazide (G) was added to the bile acid, it augmented the hypoglycaemic effect. In a recent study, we designed a new formulation of gliclazide-cholic acid (G-CA), with good structural properties, excipient compatibility and exhibits pseudoplastic-thixotropic characteristics. The aim of this study is to test the slow release and pH-controlled properties of this new formulation. The aim is also to examine the effect of CA on G release kinetics at various pH values and different temperatures. Method: Microencapsulation was carried out using our Buchi-based microencapsulating system developed in our laboratory. Using sodium alginate (SA) polymer, both formulations were prepared: G-SA (control) and G-CA-SA (test) at a constant ratio (1:3:30), respectively. Microcapsules were examined for efficiency, size, release kinetics, stability and swelling studies at pH 1.5, pH 3, pH 7.4 and pH 7.8 and temperatures of 20 and 30 °C. Results: The new formulation is further optimised by the addition of CA. CA reduced microcapsule swelling of the microcapsules at pH 7.8 and pH 3 at 30 °C and pH 3 at 20 °C, and, even though microcapsule size remains similar after CA addition, percent G release was enhanced at high pH values (pH 7.4 and pH 7.8, p < 0.01). Conclusion: The new formulation exhibits colon-targeted delivery and the addition of CA prolonged G release suggesting its suitability for the sustained and targeted delivery of G and CA to the lower intestine

Text-to-Speech Personalization

Tato práce si klade za cíl vytvořit model, který dokáže převést vstupní text na řeč cílového mluvčího. Základním stavebním kamenem je VITS model. Postup byl následující: získal se obecný český dataset, na kterém se natrénoval model neuronové sítě, jenž se poté využil pro generování audio nahrávek, které se vyhodnocovaly pomocí objektivních metrik. Následně se vytvořil personalizovaný dataset, na kterém se provedl fine-tuning modelu získaného v předchozím kroku. Opět se provedlo vyhodnocení kvality nahrávek. Výsledkem jsou dva personalizované modely. Model mužského mluvčího dosáhl v poslechových testech skóre 4.12/5 (MOS), model ženské mluvčí pak 3.02/5. Výsledky sub\-jektivních i objektivních metrik ukázaly, že postupem zvoleným v této práci je možné vyvinout model, který se svou kvalitou generovaných nahrávek blíží skutečné řeči. Přínosem této práce je, kromě personalizovaných modelů, i vytvoření vyhodnocovacího systému zpracování dat, které je možno uzpůsobit k evaluaci audio nahrávek z jiných mo\-de\-lů. Práce popisuje i způsob tvorby nového datasetu, který se může využít při tvorbě dalšího jiného datasetu v libovolném jazyce