423 research outputs found
Structural optimization with fatigue and ultimate limit constraints of jacket structures for large offshore wind turbines
Resuspension studies in cylindrical microcosms: Effects of stirring velocity on the dynamics of redox sensitive elements in a coastal sediment
Silica-waveguide thermooptic phase shifter with low power consumption and low lateral heat diffusion
Identification of patients with new-onset heart failure and reduced ejection fraction in Danish administrative registers
Experimental determination of the degree of quantum polarisation of continuous variable states
We demonstrate excitation-manifold resolved polarisation characterisation of
continuous-variable (CV) quantum states. In contrast to traditional
characterisation of polarisation that is based on the Stokes parameters, we
experimentally determine the Stokes vector of each excitation manifold
separately. Only for states with a given photon number does the methods
coincide. For states with an indeterminate photon number, for example Gaussian
states, the employed method gives a richer and more accurate description. We
apply the method both in theory and in experiment to some common states to
demonstrate its advantages.Comment: 5 page
Long-Term Mortality Associated With Use of Carvedilol Versus Metoprolol in Heart Failure Patients With and Without Type 2 Diabetes:A Danish Nationwide Cohort Study
BACKGROUND: Carvedilol may have favorable glycemic properties compared with metoprolol, but it is unknown if carvedilol has mortality benefit over metoprolol in patients with type 2 diabetes (T2D) and heart failure with reduced ejection fraction (HFrEF). METHODS AND RESULTS: Using Danish nationwide databases between 2010 and 2018, we followed patients with newâonset HFrEF treated with either carvedilol or metoprolol for allâcause mortality until the end of 2018. Followâup started 120Â days after initial HFrEF diagnosis to allow initiation of guidelineâdirected medical therapy. There were 39Â 260 patients on carvedilol or metoprolol at baseline (mean age 70.8Â years, 35% women), of which 9355 (24%) had T2D. Carvedilol was used in 2989 (32%) patients with T2D and 10Â 411 (35%) of patients without T2D. Users of carvedilol had a lower prevalence of atrial fibrillation (20% versus 35%), but other characteristics appeared wellâbalanced between the groups. Totally 11Â 306 (29%) were deceased by the end of followâup. We observed no mortality differences between carvedilol and metoprolol, multivariableâadjusted hazard ratio (HR) 0.97 (0.90â1.05) in patients with T2D versus 1.00 (0.95â1.05) for those without T2D, P for difference =0.99. Rates of newâonset T2D were lower in users of carvedilol versus metoprolol; age, sex, and calendar year adjusted HR 0.83 (0.75â0.91), P<0.0001. CONCLUSIONS: In a contemporary clinical cohort of HFrEF patients with and without T2D, carvedilol was not associated with a reduction in longâterm mortality compared with metoprolol. However, carvedilol was associated with lowered risk of newâonset T2D supporting the assertion that carvedilol has a more favorable metabolic profile than metoprolol
Parsing polarization squeezing into Fock layers
We investigate polarization squeezing in squeezed coherent states with varying coherent amplitudes. In contrast to the traditional characterization based on the full Stokes parameters, we experimentally determine the Stokes vector of each excitation subspace separately. Only for states with a fixed photon number do the methods coincide; when the photon number is indefinite, we parse the state in Fock layers, finding that substantially higher squeezing can be observed in some of the single layers. By capitalizing on the properties of the Husimi Q function, we map this notion onto the PoincarĂŠ space, providing a full account of the measured squeezing
Heart failure and the prognostic impact and incidence of new-onset of diabetes mellitus:A nationwide cohort study
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