Homogenization of very thin elastic reticulated structures

This work is devoted to the homogenization of the anisotropic, linearized elasticity system posed on thin reticulated structures involving several parameters. We show that the result depends on the relative size of the parameters. In every case, we obtain a limit problem where both the microscopic and macroscopic scales appear together. From this problem, we get an asymptotic development which gives an approximation in L2 of the displacements and the linearized strain tensor.Ministerio de Ciencia y Tecnologí

Circulating anti-galectin-1 antibodies are associated with the severity of ocular disease in autoimmune and infectious uveitis

Galectin (Gal)-1, an endogenous lectin found at sites of immune privilege, plays a critical role in the regulation of the immune response. Therapeutic administration of Gal-1 or its genetic delivery suppresses chronic inflammation in experimental models of autoimmunity. The purpose of this work was to investigate the occurrence of circulating anti-Gal-1 antibodies in patients with autoimmune and infectious uveitis as potential determinant factors of disease progression.Fil: Romero, Marta D.. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Fundación Ver; Argentina. Laboratorio Inmunopatología Investigación y Docencia LIIDO; ArgentinaFil: Muiño, Juan Carlos. Universidad Nacional de Córdoba; Argentina. Fundación Ver; ArgentinaFil: Bianco, German Ariel. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Ferrero, Mercedes. Laboratorio Inmunopatología Investigación y Docencia LIIDO; Argentina. Fundación Ver; ArgentinaFil: Juarez, Claudio P.. Fundación Ver; ArgentinaFil: Luna, José Domingo. Fundación Ver; ArgentinaFil: Rabinovich, Gabriel A.. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentin

El benchmarking en las comercializadoras de Guayaquil. ¿Cómo sería esta técnica?

Introduction. Globalization continues to be the phenomenon that most affects organizations, and for which they seek to optimize all their processes with a view to achieving profitability, therefore they must face the competitiveness of the markets and develop competitive advantages that allow them to achieve their objectives. and goals. Objective. Analyze the Benchmarking technique in the marketers of Guayaquil. Methodology. Based on bibliographic design, through bibliographic research. Results. The constant changes in the global economy, as well as the pinnacle of technology, force companies to look for alternatives that allow them to continue operating optimally and efficiently, for which they must adopt the implementation of administrative tools that contribute to the achievement of their goals and its good internal functioning. Conclution. There are various tools, which can be used to improve various processes, however, in this document we will talk about Benchmarking, which is a tool that is based on comparing the processes and/or activities of a company with others that have a high degree of profitability and acceptance among consumers. It is not about copying but about selecting everything that can work in our company in a way, which is why it is worth adopting the techniques and adapting them to internal processes.Introducción. La globalización sigue siendo el fenómeno que más afecta a las organizaciones, y por el cual estas buscan optimizar todos sus procesos con miras a lograr la rentabilidad, por ello deben hacer frente a la competitividad de los mercados y desarrollar ventajas competitivas que permitan alcanzar sus objetivos y metas. Objetivo. Analizar la técnica del Benchmarking en las comercializadoras de Guayaquil. Metodología. Basada en el diseño bibliográfico, través de la investigación bibliográfica. Resultados. Los cambios constantes en la economía global, así como el pináculo de la tecnología, obliga a las empresas a buscar alternativas que le permitan seguir funcionando de manera óptima y eficaz, por lo cual deben adoptar la implementación de herramientas administrativas que contribuyan al logro de sus metas y su buen funcionamiento interno. Conclusión. Existen diversas herramientas, las cuales pueden ser utilizadas para mejorar diversos procesos, sin embargo, en el presente documento hablaremos sobre el Benchmarking, la cual es una herramienta que se basa en comparar sus procesos y/o actividades de una empresa con otras que cuentan con un alto grado de rentabilidad y aceptación entre los consumidores. No se trata de copiar sino de seleccionar todo aquello que de una manera puede funcionar en nuestra empresa, por lo cual amerita adoptar las técnicas y adecuarlas a los procesos internos

Galectin-1 expression imprints a neurovascular phenotype in proliferative retinopathies and delineates responses to anti-VEGF

Neovascular retinopathies are leading causes of irreversible blindness. Although vascular endothelial growth factor (VEGF) inhibitors have been established as the mainstay of current treatment, clinical management of these diseases is still limited. As retinal impairment involves abnormal neovascularization and neuronal degeneration, we evaluated here the involvement of galectin-1 in vascular and non-vascular alterations associated with retinopathies, using the oxygen-induced retinopathy (OIR) model. Postnatal day 17 OIR mouse retinas showed the highest neovascular profile and exhibited neuro-glial injury as well as retinal functional loss, which persisted until P26 OIR. Concomitant to VEGF up-regulation, galectin-1 was highly expressed in P17 OIR retinas and it was mainly localized in neovascular tufts. In addition, OIR induced remodelling of cell surface glycophenotype leading to exposure of galectin-1-specific glycan epitopes. Whereas VEGF returned to baseline levels at P26, increased galectin-1 expression persisted until this time period. Remarkably, although anti-VEGF treatment in P17 OIR improved retinal vascularization, neither galectin-1 expression nor non-vascular and functional alterations were attenuated. However, this functional defect was partially prevented in galectin-1-deficient (Lgals1-/-) OIR mice, suggesting the importance of targeting both VEGF and galectin-1 as non-redundant independent pathways. Supporting the clinical relevance of these findings, we found increased levels of galectin-1 in aqueous humor from patients with proliferative diabetic retinopathy and neovascular glaucoma. Thus, using an OIR model and human samples, we identified a role for galectin-1 accompanying vascular and non-vascular retinal alterations in neovascular retinopathies.Fil: Ridano, Magali Evelin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Subirada Caldarone, Paula Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Paz, Maria Constanza. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Lorenc, Valeria Erika. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Stupirski, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Gramajo, Ana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología - Nodo Bariloche | Comisión Nacional de Energía Atómica. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología. Unidad Ejecutora Instituto de Nanociencia y Nanotecnología - Nodo Bariloche; ArgentinaFil: Luna, José Domingo. Clinica de Ojos Romagosa, Fundacion Ver; ArgentinaFil: Croci Russo, Diego Omar. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaFil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad Nacional de Córdoba. Facultad de Cs.exactas Físicas y Naturales. Departamento de Química. Cátedra de Química Biologica; ArgentinaFil: Garcia Sanchez, Maria Candela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentin

Biases in precipitation records found in parallel measurements

Presentación realizada en: 10th EUMETNET Data Management Workshop celebrado en St. Gallen, Suiza, del 28 al 30 de octubre de 2015.In this work we investigate biases introduced by the transition from Conventional to automatic precipitation measurements. This is another study in the framework of The Parallel Observations Scientific Team (POST, http://www.surfacetemperatures.org/databank/parallel_measurements), which is a newly created group of the International Surface Temperature Initiative (ISTI) supported by the World Meteorological Organization (WMO). The goals of POST are the study of climate data inhomogeneities at the daily and sub-daily level. Long instrumental climate records are usually affected by non-climatic changes, due to various reasons like relocations, changes in instrumentation, measurements schemes etc. Such inhomogeneities may distort the climate signal and can influence the assessment of trends and variability. For studying climatic changes it is important to accurately distinguish non-climatic from climatic signals. This can be achieved by studying the differences between two parallel measurements. These need to be sufficiently close together to be well correlated. One important ongoing worldwide transition is the one from manual to automated measurements. We need to study the impact of automated measurements urgently because sooner or later this will affect most of the stations in individual national networks. Similar to temperature series, we study the transition from conventional manual measurements (CON) to Automatic Weather Stations (AWS), using several parallel datasets distributed over Europe and America. The ratio series AWS-CON are subject to quality control, and before the analysis obvious errors are removed. Further, the series are inspected for internal inhomogeneities and– if necessary –the records are split into two or more homogeneous segments. Finally, each segment is studied to understand the biases introduced by the transition, its seasonality as well as changes in the empirical distributions. When additional variables are available, an attempt is made to study the effects of other variables on the observed biases

Description of the bias introduced by the transition from Conventional Manual Measurements to Automatic Weather Station through the analysis of European and American parallel datasets (+ Australia, Israel & Kyrgyzstan)

Presentación realizada en: 10th EUMETNET Data Management Workshop celebrado en St. Gallen, Suiza, del 28 al 30 de octubre de 2015.In this work, we approach the description of the biases introduced by automation in temperature records. This is one of the first studies in the framework of The Parallel Observations Scientific Team (POST). POST is a newly created group of the International Surface Temperature Initiative (ISTI), with the support of the World Meteorological Organization (WMO). The goals of POST (http://www.surfacetemperatures.org/databank/parallel_measurements) are the study of climate data inhomogeneities at the daily and sub-daily level through the compilation and analysis of parallel measurements. Long instrumental climate records are usually affected by non-climatic changes, due to, e.g., relocations and changes in instrumentation, instrument height or data collection and manipulation procedures. These so-called inhomogeneities distort the climate signal and can hamper the assessment of trends and variability. Thus to study climatic changes we need to accurately distinguish non-climatic and climatic signals. The most direct way to study the influence of non-climatic changes on the distribution and to understand the reasons for these biases is the analysis of parallel measurements. A parallel measurement is composed of two or more time series, which measure a climatic variable with two different systems (for example, Montsouris and Stevenson Screens) or in two different locations (for example, city centre and airport). They mimic the situation “before” and “after” a homogeneity break. Most parallel measurements are obtained from collocated or nearly collocated series and can help us to understand the size and shape of different typical sources of inhomogeneity, which affect the climate series. Here we study the transition from conventional temperature manual measurements (CON) to Automatic Weather Stations (AWS), using several parallel datasets distributed over Europe and America. The variables studied in the analysis presented here are daily maximum and minimum temperature. First of all, the metadata – when available - is gathered to gain knowledge on the exact setting of the parallel series. Secondly, the difference (temperature) series AWS-CON are submitted to quality control, to remove obvious errors and inspected to detect internal inhomogeneities and split if necessary. In a third step, each segment is studied to understand the bias introduced by the transition, its seasonality as well as changes in the empirical distributions. When additional variables are available, an attempt is made to study the effects of other variables on the observed biases.With the support of Grant CGL2012-32193, Ministerio de Economía y Competitividad, MINECO, España and FP7-SPACE-2013-1 grand 607193, Uncertainties in Ensembles of Regional Reanalyses (UERRA)

Efficacy and Safety of Oral Fosfomycin for Asymptomatic Bacteriuria in Kidney Transplant Recipients: Results from a Spanish Multicenter Cohort

Current guidelines recommend against systematic screening for or treating asymptomatic bacteriuria (AB) among kidney transplant (KT) recipients, although the evidence regarding episodes occurring early after transplantation or in the presence of anatomical abnormalities is inconclusive. Oral fosfomycin may constitute a good option for the treatment of posttransplant AB, particularly due to the emergence of multidrug-resistant (MDR) uropathogens. Available clinical evidence supporting its use in this specific setting, however, remains scarce. We performed a retrospective study in 14 Spanish institutions from January 2005 to December 2017. Overall, 137 episodes of AB diagnosed in 133 KT recipients treated with oral fosfomycin (calcium and trometamol salts) with a test-of-cure urine culture within the first 30 days were included. Median time from transplantation to diagnosis was 3.1 months (interquartile range [IQR], 1.1 to 10.5). Most episodes (96.4% [132/137]) were caused by Gram-negative bacteria (GNB), and 56.9% (78/137) were categorized as MDR (extended?spectrum ??lactamase?producing Enterobacterales [20.4%] and carbapenem?resistant GNB [2.9%]). Rate of microbiological failure at month 1 was 40.1% (95% confidence interval [CI], 31.9% to 48.9%) for the whole cohort and 42.3% (95% CI, 31.2% to 54.0%) for episodes due to MDR pathogens. Previous urinary tract infection (odds ratio [OR], 2.42; 95% CI, 1.11 to 5.29; P value = 0.027) and use of fosfomycin as salvage therapy (OR, 8.31; 95% CI, 1.67 to 41.35; P value = 0.010) were predictors of microbiological failure. No severe treatment-related adverse events were detected. Oral fosfomycin appears to be a suitable and safe alternative for the treatment (if indicated) of AB after KT, including those episodes due to MDR uropathogens.ACKNOWLEDGMENTS This study was supported by Plan Nacional de I+D+i 2013‐2016 and Instituto de Salud Carlos III (ISCIII), Subdirección General de Redes y Centros de Investigación Cooperativa, Ministry of Science and Innovation, Spanish Network for Research in Infectious Diseases (REIPI RD16/0016), and Spanish Network for Research in Renal Diseases (REDInREN RD16/0009) and cofinanced by the European Development Regional Fund entitled A way to achieve Europe. M.F.-R. holds a research contract (Miguel Servet, CP18/00073), from the Spanish Ministry of Science and Innovation, ISCIII. Funding sources were not involved in the study design and conduction, data analysis, or manuscript preparation

Oral fosfomycin for the treatment of lower urinary tract infections among kidney transplant recipients—Results of a Spanish multicenter cohort

Preliminary results of this study were presented at the 29th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), held in Amsterdam, The Netherlands, from 13 to 16 April, 2019 (oral communication O‐0699).Oral fosfomycin may constitute an alternative for the treatment of lower urinary tract infections (UTIs) in kidney transplant recipients (KTRs), particularly in view of recent safety concerns with fluroquinolones. Specific data on the efficacy and safety of fosfomycin in KTR are scarce. We performed a retrospective study in 14 Spanish hospitals including KTRs treated with oral fosfomycin (calcium and trometamol salts) for posttransplant cystitis between January 2005 and December 2017. A total of 133 KTRs developed 143 episodes of cystitis. Most episodes (131 [91.6%]) were produced by gram‐negative bacilli (GNB), and 78 (54.5%) were categorized as multidrug resistant (including extended‐spectrum β‐lactamase‐producing Enterobacteriaceae [14%] or carbapenem‐resistant GNB [3.5%]). A median daily dose of 1.5 g of fosfomycin (interquartile range [IQR]: 1.5‐2) was administered for a median of 7 days (IQR: 3‐10). Clinical cure (remission of UTI‐attributable symptoms at the end of therapy) was achieved in 83.9% (120/143) episodes. Among those episodes with follow‐up urine culture, microbiological cure at month 1 was achieved in 70.2% (59/84) episodes. Percutaneous nephrostomy was associated with a lower probability of clinical cure (adjusted odds ratio: 10.50; 95% confidence interval: 0.98‐112.29; P = 0.052). In conclusion, fosfomycin is an effective orally available alternative for treating cystitis among KTRs.This study was supported by Plan Nacional de I+D+i 2013‐2016 and Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Ciencia, Innovación y Universidades, Spanish Network for Research in Infectious Diseases (REIPI RD16/0016)—cofinanced by the European Development Regional Fund “A way to achieve Europe”; the Group for Study of Infection in Transplantation and the Immunocompromised Host (GESITRA‐IC) of the Spanish Society of Clinical Microbiology and Infectious Diseases (SEIMC); and the Spanish Network for Research in Renal Diseases (REDInREN RD16/0009). MFR holds a research contract “Miguel Servet” (CP 18/00073) from the Spanish Ministry of Science, Innovation and Universities, Instituto de Salud Carlos III