The Use of Plasmapheresis in Treatment of Patients with Infertility, Peritoneal Endometriosis and Nat2 Gene Polymorphism

It is known that 30–40 % of patients with peritoneal endometriosis suffer from infertility. Half of the patients with endometriosis are identified point mutation in NAT2 – gene, which plays an important role in the acetylation of aromatic and heterocyclic amines, in the accumulation of endotoxins, activation of free radical oxidation, impaired microcirculation. These factors involve the use of methods of gemapheresis which have detoxification, the blood rheology corrective and immune corrective effects. The purpose of this study was to evaluate the efficacy of therapeutic plasma exchange in treatment of patients with peritoneal form of endometriosis, infertility and point mutations in the gene NAT2. The study included 140 patients with infertility, peritoneal form of endometriosis and point mutations in the gene NAT2. All patients are performed laparoscopy, coagulation foci of endometriosis. In the following 93 (66.4 %) patients were treated with a the course of therapeutic plasmapheresis using the apparatus «PCS-2» with the removal of 20–25 % the volume of circulating plasma with replacement plasma of crystalloid and colloid solutions. Before treatment were shown the signs of endotoxemia, activation of oxidative stress. After treatment with the use of plasmapheresis was revealed the significant reduction of endogenous intoxication parameters and oxidative stress. Also is noted the increase in the pregnancy rate, both independently and in IVF programs, especially during the first 3 months after treatment. The findings suggest that the efficiency of the proposed comprehensive treatment techniques (laparoscopy and subsequent course of therapeutic plasmapheresis) of patients with peritoneal endometriosis and infertility and with point mutations in the gene NAT2. The use of plasmapheresis is pathogenetically justified in patients of the studied group

СТРАНИЦА БИБЛИОГРАФА

.Коллектив Научной медицинской  библиотеки НИИ СП имени  Н.В. Склифосовского представляет  читателям журнала обзор монографий, методических материалов и сборников научных трудов, опубликованных на русском языке в последние годы

НЕКОТОРЫЕ НАУКОМЕТРИЧЕСКИЕ КРИТЕРИИ ОЦЕНКИ НАУЧНОЙ ДЕЯТЕЛЬНОСТИ

ABSTRACT. The most usable formal criteria for measuring the research impact in our country have been reviewed: impact factor of a publication (IMP), citation index (CI), h-index. РЕЗЮМЕ. В статье представлены определения и область применения наиболее используемых в нашей стране формальных критериев оценки результатов научной деятельности, в частности: импакт-фактор журнала, индекс цитирования, индекс Хирша.

Страница библиографа

Page of our Bibliographer.В обзоре изданий, посвященных широкому спектру разделов неотложной медицины, вышедших в различных регионах за последние годы на русском языке, нашли отражение краткие аннотации наиболее востребованных у коллег в стенах научно-медицинской библиотеки НИИ СП им. Н.В. Склифосовского печатных публикаций

СТРАНИЦА БИБЛИОГРАФА

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ALEXANDER VLADIMIROVICH GRIGORIEV (MARI) IS A PROVINCIAL ARTIST IN THE CONTEXT OF RUSSIAN STATEHOOD

В статье освещается деятельность горномарийского художника А.В. Григорьева в плане образования музея в провинциальном городе Поволжья. Его живое участие в революционной деятельности и поднятии уровня образования средиThe article highlights the activities of the mining artist A.V. Grigoriev in terms of the formation of a museum in a provincial town of the Volga region. His active participation in revolutionary activities and raising the level of education among fellow countrymen made a significant contribution to the establishment of a new system in the homeland. The tireless work on the acquisition of the museum’s funds with its subsequent involvement in the elimination of illiteracy of the population has given far-reaching prospects. Further development of the museum business was continued, the fate of the artist was waiting for a political conclusion

Peasant social utopia in England in the XIIIth - XIVth centuries

This article presents several aspects of peasants’ social utopia in England in the XIIIth- XIVth centurie

Results of surgical treatment of ptosis of the upper eyelid by the dosed muscle-conjunctival resection of the upper cartilage

Blepharoptosis is an abnormally low position of the upper eyelid in relation to the eyeball due to its omission. The method of surgical treatment of blepharoptosis depends on the function of the levator.The aim. To analyze the results of surgical treatment of partial blepharoptosis of various etiology by the dosed muscle-conjunctival resection of the upper eyelid cartilage.Material and methods. We operated 78 patients (82 eyes) with blepharoptosis, among them with congenital blepharoptosis – 34 people (36 eyes), with acquired – 44 (46 eyes). The patients’ age was from 6 to 82 years.Inclusion criteria: the function of the upper eyelid levator – more than 5 mm, the width of the palpebral fissure – 3 mm or more.The patients underwent a dosed muscle-conjunctival resection of the upper eyelid cartilage in the period from 2018 to 2021. The follow-up period ranged from 2 months to 2 years.Results. Elimination of blepharoptosis was achieved in all patients. With congenital blepharoptosis, a good result was obtained in 33  people (91.7  %), satisfactory – in three patients (8.3 %), which was associated with the asymmetry of the palpebral fissure, for the correction of which these patients underwent additional intervention. In patients with acquired ptosis of the upper eyelid, a good result was achieved in 91.3 % of cases (42 eyes). One patient underwent repeated surgery due to hypocorrection and asymmetry of the palpebral fissure width after the first surgery.In all patients, the result remained stable throughout the observation period.Conclusion. The use of the method of dosed muscle-conjunctival resection of the upper eyelid cartilage in patients with partial ptosis of the upper eyelid and intact levator function made it possible to obtain a good cosmetic and functional result: with congenital blepharoptosis – in 91.7 % of cases, acquired ptosis of the upper eyelid – in 91.3 % patients

Lexical interaction of the modern Greek language with Germanic and Romance languages (with reference to the vocabulary of English, French and modern Greek languages)

The article deals with the issues of lexical interaction of the modern Greek language with Germanic and Romance languages (represented by English and French). There were singled out two areas in which this lexical interaction is rather significant: the vocabulary related to food and drinks and the vocabulary used to designate objects and concepts of clothing, shoes, haberdashery and perfumer

Application of information and analytical system of analysis of the financial condition and business activity of the enterprise

The work is devoted to the questions of the information-analytical system of analysis of the financial condition and business activity of the enterprise.Работа посвящена вопросам информационно-аналитической системы анализа финансового состояния и деловой активности предприятия