Keabsahan dan Kebolehpercayaan Instrumen Psikometrik Ujian Tingkah Laku Hasrat Bunuh Diri

Instrumen Ujian Tingkah Laku Hasrat Bunuh Diri (SIBA) dihasilkan untuk mengukur tahap tingkah laku hasrat bunuh diri dalam kalangan penagih di Malaysia bagi membantu mereka dan kerajaan mengurangkan kes bunuh diri di negara ini. Kajian ini bertujuan menghasilkan bukti empirikal mengenai keabsahan dan kebolehpercayaan instrumen SIBA dengan menggunakan model pembinaan instrumen daripada Miller et al. (2013), yang telah diubahsuai. Pembinaan instrumen itu dibuat berdasarkan satu kerangka konseptual yang dibentuk secara hipotetikal dan hasil kajian pengkaji-pengkaji terdahulu yang telah membuat penelitian secara mendalam tentang hubungan penagihan dadah dengan tingkah laku hasrat bunuh diri. Instrumen ini mengandungi empat komponen iaitu konflik interpersonal, kecelaruan emosi, kemurungan, dan putus harapan. Setiap komponen SIBA mengandungi 10 item dan jumlah keseluruhannya ialah 40 item. Analisis Faktor Eksploratori (Exploratory Factor Analysis – EFA) digunakan untuk menentukan keabsahan dan kebolehpercayaan setiap item dalam komponen-komponen tersebut. Dalam hal ini, seramai 123 penagih yang dirawat di Cure & Care Rehabilitation Centre (CCRC) Besut, Terengganu dipilih sebagai responden kajian untuk pengujian instrumen ini. Kajian ini mendapati bahawa muatan faktor untuk setiap item adalah dalam julat 0.45 hingga 0.87 dan nilai kebolehpercayaan (alpha) pula adalah dalam julat 0.83-0.90. Dapatan kajian ini jelas menunjukkan instrumen ini mempunyai keabsahan dan kebolehpercayaan yang tinggi dan boleh diguna pakai dalam mengukur tahap tingkah laku hasrat bunuh diri dalam kalangan penagih dadah di CCRC, Besut. Secara keseluruhannya, analisis keabsahan dan kebolehpercayaan ini adalah penting bagi memastikan penghasilan instrumen SIBA ini boleh diguna pakai untuk mengukur tahap tingkah laku hasrat bunuh diri dalam kalangan penagih dadah yang berkualiti dan bermakna

How to Develop Character Education of Madrassa Students in Indonesia

In the last decades, the teachers criticized for failing to integrate the knowledge in the behavior of virtue. Therefore the character education is always considered in every design education, including in madrassas. The character education is the deliberate attempt to influence the behavior of students through customizing repeatedly. making it easy to do virtue and avoid crime. The research has focused on the approach to character education at madrassa. The qualitative method by interviewing, observation, and focus groups have been used in this study.A total of 16 teachers at four madrassas in South Sulawesi has been selected through purposive Sampling. The research suggest: Madrassa teachers have not managed to practice the concept of teaching character. Both conceptually and contextually. The failure of conceptually caused teachers do not embed character values are extracted from the behavior of student's virtue. While the failure of the contextually is has caused teachers failed in an attempt to develop character values, such as social relationships, honesty, and discipline. In addition, the teachers are not managed to practice courteous and not empowered to detain students of behavior lie

"An effective two dimensionality" cases bring a new hope to the Kaluza-Klein[like] theories

One step towards realistic Kaluza-Klein[like] theories and a loop hole through the Witten's "no-go theorem" is presented for cases which we call an effective two dimensionality cases: In $d=2$ the equations of motion following from the action with the linear curvature leave spin connections and zweibeins undetermined. We present the case of a spinor in $d=(1+5)$ compactified on a formally infinite disc with the zweibein which makes a disc curved on an almost $S^2$ and with the spin connection field which allows on such a sphere only one massless normalizable spinor state of a particular charge, which couples the spinor chirally to the corresponding Kaluza-Klein gauge field. We assume no external gauge fields. The masslessness of a spinor is achieved by the choice of a spin connection field (which breaks parity), the zweibein and the normalizability condition for spinor states, which guarantee a discrete spectrum forming the complete basis. We discuss the meaning of the hole, which manifests the noncompactness of the space.Comment: 26 pages, 1 figure, an addition which helps to clarify the assumptions and their consequences (the discreteness of spectrum, the massless solution of one handedness,..

Quality of life satisfaction among converted Kelantan Chinese Muslims

This article investigates the quality of life of the Kelantan Chinese Muslim community before and after conversion to Islam, focusing on their level of satisfaction in term of economic aspect. This research was carried out using the sequential explanatory mixed method design involving 75 respondents selected for quantitative and five respondents for qualitative. The sampling method adopted was convenience and snowball samplings. The research data was collected using questionnaires and semi-structured interviews. The results revealed that respondents were moderately satisfied before conversion and satisfied after conversion. Besides that, there is no significant difference of quality of life before and after conversion to Islam (F = 0.868, p = 0.355) and it was not influenced by the period of conversion to Islam (F = 0.832, p = 0.589). This analysis indicates numerous respondents are still moderately satisfied in their quality of life even though the average data shows they are satisfied after conversion

Free Energy Simulations of a GTPase: GTP and GDP Binding to Archaeal Initiation Factor 2

International audienceArchaeal initiation factor 2 (aIF2) is a protein involved in the initiation of protein biosynthesis. In its GTP-bound, "ON" conformation, aIF2 binds an initiator tRNA and carries it to the ribosome. In its GDP-bound, "OFF" conformation, it dissociates from tRNA. To understand the specific binding of GTP and GDP and its dependence on the ON or OFF conformational state of aIF2, molecular dynamics free energy simulations (MDFE) are a tool of choice. However, the validity of the computed free energies depends on the simulation model, including the force field and the boundary conditions, and on the extent of conformational sampling in the simulations. aIF2 and other GTPases present specific difficulties; in particular, the nucleotide ligand coordinates a divalent Mg(2+) ion, which can polarize the electronic distribution of its environment. Thus, a force field with an explicit treatment of electronic polarizability could be necessary, rather than a simpler, fixed charge force field. Here, we begin by comparing a fixed charge force field to quantum chemical calculations and experiment for Mg(2+):phosphate binding in solution, with the force field giving large errors. Next, we consider GTP and GDP bound to aIF2 and we compare two fixed charge force fields to the recent, polarizable, AMOEBA force field, extended here in a simple, approximate manner to include GTP. We focus on a quantity that approximates the free energy to change GTP into GDP. Despite the errors seen for Mg(2+):phosphate binding in solution, we observe a substantial cancellation of errors when we compare the free energy change in the protein to that in solution, or when we compare the protein ON and OFF states. Finally, we have used the fixed charge force field to perform MDFE simulations and alchemically transform GTP into GDP in the protein and in solution. With a total of about 200 ns of molecular dynamics, we obtain good convergence and a reasonable statistical uncertainty, comparable to the force field uncertainty, and somewhat lower than the predicted GTP/GDP binding free energy differences. The sign and magnitudes of the differences can thus be interpreted at a semiquantitative level, and are found to be consistent with the experimental binding preferences of ON- and OFF-aIF2

Mechanisms of Intramolecular Communication in a Hyperthermophilic Acylaminoacyl Peptidase: A Molecular Dynamics Investigation

Protein dynamics and the underlying networks of intramolecular interactions and communicating residues within the three-dimensional (3D) structure are known to influence protein function and stability, as well as to modulate conformational changes and allostery. Acylaminoacyl peptidase (AAP) subfamily of enzymes belongs to a unique class of serine proteases, the prolyl oligopeptidase (POP) family, which has not been thoroughly investigated yet. POPs have a characteristic multidomain three-dimensional architecture with the active site at the interface of the C-terminal catalytic domain and a β-propeller domain, whose N-terminal region acts as a bridge to the hydrolase domain. In the present contribution, protein dynamics signatures of a hyperthermophilic acylaminoacyl peptidase (AAP) of the prolyl oligopeptidase (POP) family, as well as of a deletion variant and alanine mutants (I12A, V13A, V16A, L19A, I20A) are reported. In particular, we aimed at identifying crucial residues for long range communications to the catalytic site or promoting the conformational changes to switch from closed to open ApAAP conformations. Our investigation shows that the N-terminal α1-helix mediates structural intramolecular communication to the catalytic site, concurring to the maintenance of a proper functional architecture of the catalytic triad. Main determinants of the effects induced by α1-helix are a subset of hydrophobic residues (V16, L19 and I20). Moreover, a subset of residues characterized by relevant interaction networks or coupled motions have been identified, which are likely to modulate the conformational properties at the interdomain interface