Superoxide- and no-dependent mechanisms of antitumor and antimetastatic effect of L-arginine hydrochloride and coenzyme Q₁₀

Aim: To study the redox-dependent mechanism of antiradical, antitumor and antimetastatic action of L-arginine hydrochloride (L-Arg) and coenzyme Q₁₀ (CoQ₁₀) in vivo. Materials and Methods: The study was performed on С57Вl mice with transplanted Lewis lung carcinoma treated by intraperitoneal injections of L-Arg at low or high doses (60 and 360 mg/kg body weight), CoQ₁₀ (0.2 and 1.2 mg/kg body weight) or their combinations. Electron paramagnetic resonance was applied for analysis of mitochondrial electron transport chain, СoQ₁₀ levels, free iron (FI), the level of NO, and the rate of superoxide radical generation. The activity of matrix metalloproteinase (MMP)-2 and -9 in tumor tissue was determined by zymography method in polyacrylamide gel. Results: Administration of L-Arg at high doses caused an inhibition of tumor growth by 48 ± 8.0%, increase of superoxide radical generation rate and NO levels to a value of 1.23 ± 0.14 аnd 2.26 ± 0.31 nm/g tissue · min, and decreased activity of MMP-2 and -9 (3.55 ± 0.8 and 4.8 ± 1.0 r.u., respectively). Treatment with L-Arg at low doses stimulated tumor growth and increased the levels of MMP-2 and -9 activities (8.44 ± 2.7 and 9.8 ± 3.1 r.u., respectively). Administration of СoQ₁₀ at high doses significantly decreased superoxide radical generation rate to the values of 0.44 ± 0.09 nm/g tissue · min, levels of free iron and NO, and caused tumor growth inhibition by 54 ± 11.3%. The combined use of L-Arg and СoQ₁₀ at high doses caused tumor growth inhibition by 51 ± 7.4% compared to Lewis lung carcinoma-bearing untreated animals (р < 0.05). Conclusions: Administration of L-Arg and СoQ₁₀ caused the dose-dependent effect on the rate of generation of superoxide radicals, level of ubisemyquinone, complexes NOFeS-proteins, levels of FI and NO. L-Arg at low doses positively modulated MMP-9 activity that promoted tumor progression. Upon combined use of L-Arg and СoQ₁₀, superoxide radicals and NO form the redox state that causes decrease of MMP-2, -9 activities with consequent inhibition of tumor invasion and metastasis

Study of KS KL Coupled Decays and KL -Be Interactions with the CMD-2 Detector at VEPP-2M Collider

The integrated luminosity about 4000 inverse nanobarn of around phi meson mass ( 5 millions of phi mesons) has been collected with the CMD-2 detector at the VEPP-2M collider. A latest analysis of the KS KL coupled decays based on 30 % of available data is presented in this paper. The KS KL pairs from phi meson decays were reconstructed in the drift chamber when both kaons decayed into two charged particles. From a sample of 1423 coupled decays a selection of candidates to the CP violating KL into pi+ pi- decay was performed. CP violating decays were not identified because of the domination of events with a KL regenerating at the Be beam pipe into KS and a background from KL semileptonic decays. The regeneration cross section of 110 MeV/c KL mesons was found to be 53 +- 17 mb in agreement with theoretical expectations. The angular distribution of KS mesons after regeneration and the total cross section of KL for Be have been measured.Comment: 14 pages, 8 figure

Multiorder coherent Raman scattering of a quantum probe field

We study the multiorder coherent Raman scattering of a quantum probe field in a far-off-resonance medium with a prepared coherence. Under the conditions of negligible dispersion and limited bandwidth, we derive a Bessel-function solution for the sideband field operators. We analytically and numerically calculate various quantum statistical characteristics of the sideband fields. We show that the multiorder coherent Raman process can replicate the statistical properties of a single-mode quantum probe field into a broad comb of generated Raman sidebands. We also study the mixing and modulation of photon statistical properties in the case of two-mode input. We show that the prepared Raman coherence and the medium length can be used as control parameters to switch a sideband field from one type of photon statistics to another type, or from a non-squeezed state to a squeezed state and vice versa.Comment: 12 pages, 7 figures, to be published in Phys. Rev.

Industrial electron accelerators type ILU

The paper describes ILU type industrial electron accelerators. Their main parameters, design, principle of action, electron beam extraction devices, wide set of auxiliary equipment for various technological processes and ways of their usage are discussed as well.Описаны промышленные ускорители электронов серии ИЛУ. Приведены основные параметры, устройство и принцип действия. Дается краткое описание систем выпуска ускоренного пучка в атмосферу для различных технологических процессов.Описано промислові прискорювачі електронів серії ЫЛП. Наведено основні параметри, будова і принцип дії. Дається короткий опис систем випуску прискореного пучку в атмосферу для різних технологічних процесів

Work status of 5 MeV 300 kW electron accelerator

Design work has been completed for the accelerating structure of high-power electron accelerator with 5 MeV, 300 kW, 176 MHz parameters. The structure is being produced in BINP workshop. The paper presents the design of the accelerating structure which consists of a chain of coaxial cavities, and block diagram of experimental workbench. Structure of the main accelerator blocks and their degree of fabrication are viewed.Закончены проектные работы по ускоряющей структуре мощного электронного ускорителя 5 МэВ, 300 кВт, 176 МГц и ведется ее изготовление в опытном производстве Института. Дается описание конструкции ускоряющей структуры, состоящей из цепочки связанных коаксиальных резонаторов. Приводится блок-схема испытательного стенда, рассматривается устройство отдельных узлов ускорителя и состояние их готовности.Закінчено проектні роботи із прискорювальної структури потужного електронного прискорювача 5 МеВ, 300 кВт, 176 МГц і ведеться її виготовлення в дослідному виробництві інституту. Дається опис конструкції прискорювальної структури, що складається з ланцюжка зв'язаних коаксіальних резонаторів. Приводиться блок-схема іспитового стенда, розглядається будова окремих вузлів прискорювача і стан їх готовності

Reading tea leaves worldwide: decoupled drivers of initial litter decomposition mass-loss rate and stabilisation

The breakdown of plant material fuels soil functioning and biodiversity. Currently, process understanding of global decomposition patterns and the drivers of such patterns are hampered by the lack of coherent large-scale datasets. We buried 36,000 individual litterbags (tea bags) worldwide and found an overall negative correlation between initial mass-loss rates and stabilization factors of plant-derived carbon, using the Tea Bag Index (TBI). The stabilization factor quantifies the degree to which easy-to-degrade components accumulate during early-stage decomposition (e.g. by environmental limitations). However, agriculture and an interaction between moisture and temperature led to a decoupling between initial mass-loss rates and stabilization, notably in colder locations. Using TBI improved mass-loss estimates of natural litter compared to models that ignored stabilization. Ignoring the transformation of dead plant material to more recalcitrant substances during early-stage decomposition, and the environmental control of this transformation, could overestimate carbon losses during early decomposition in carbon cycle models

Scatter-plot-based method for noise characteristics evaluation in remote sensing images using adaptive image clustering procedure

International audienceSeveral modifications of scatter-plot-based method for mixed noise parameters estimation are proposed. The modifications relate to the stage of image segmentation and they are intended to adaptively separate image blocks into clusters taking into account image peculiarities and to choose a required number of clusters. Comparative performance analysis of the proposed modifications for images from TID2008 database is performed. It is shown that the best estimation accuracy is provided by a method with automatic determination of a required number of clusters followed by block separation into clusters using k-means method. This modification allows improving the accuracy of noise characteristics estimation by up to 5% for both signal-independent and signal-dependent noise components in comparison to the basic method. The results for real-life data are presented. © 2016 SPIE.

Estimation aveugle de la variance d'un bruit dépendant du signal

International audienc