A technique for automatic real time scoring of several simultaneous sleep electroencephalograms

Automatic real-time scoring of simultaneous sleep electroencephalogram

Sticky Leverage

We develop a tractable general equilibrium model that captures the interplay between nominal long-term corporate debt, inflation, and real aggregates. We show that unanticipated inflation changes the real burden of debt and, more significantly, leads to a debt overhang that distorts future investment and production decisions. For these effects to be both large and very persistent, it is essential that debt maturity exceeds one period. We also show that interest rate rules can help stabilize our economy

Embeddings in Spacetimes Sourced by Scalar Fields

The extension of the Campbell-Magaard embedding theorem to general relativity with minimally-coupled scalar fields is formulated and proven. The result is applied to the case of a self-interacting scalar field for which new embeddings are found, and to Brans-Dicke theory. The relationship between Campbell-Magaard theorem and the general relativity, Cauchy and initial value problems is outlined.Comment: RevTEX (11 pages)/ To appear in the Journal of Mathematical Physic

Diels–Alder Reactions During the Biosynthesis of Sorbicillinoids

The sorbicillinoids are a class of biologically active and structurally diverse fungal polyketides arising from sorbicillin. Through co-expression of sorA, sorB, sorC, and sorD from Trichoderma reesei QM6a, the biosynthetic pathway to epoxysorbicillinol and dimeric sorbicillinoids, which resemble Diels–Alder-like and Michael-addition-like products, was reconstituted in Aspergillus oryzae NSAR1. Expression and feeding experiments demonstrated the crucial requirement of the flavin-dependent monooxygenase SorD for the formation of dimeric sorbicillinoids, hybrid sorbicillinoids, and epoxysorbicillinol in vivo. In contrast to prior reports, SorD catalyses neither the oxidation of 2',3'-dihydrosorbicillin to sorbicillin nor the oxidation of sorbicillinol to oxosorbicillinol. This is the first report that both the intermolecular Diels–Alder and Michael dimerization reactions, as well as the epoxidation of sorbicillinol are catalysed in vivo by SorD. © 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA

Cosmological Perturbations in Brane-World Theories: Formalism

We develop a gauge-invariant formalism to describe metric perturbations in five-dimensional brane-world theories. In particular, this formalism applies to models originating from heterotic M-theory. We introduce a generalized longitudinal gauge for scalar perturbations. As an application, we discuss some aspects of the evolution of fluctuations on the brane. Moreover, we show how the five-dimensional formalism can be matched to the known four-dimensional one in the limit where an effective four-dimensional description is appropriate.Comment: 16 pages, no figure, matches version to appear in PR

Interesting consequences of brane cosmology

We discuss cosmology in four dimensions within a context of brane-world scenario.Such models can predict chaotic inflation with very low reheat temperature depending on the brane tension. We notice that the gravitino abundance is different in the brane-world cosmology and by tuning the brane tension it is possible to get extremely low abundance. We also study Affleck-Dine baryogenesis in our toy model.Comment: 5 pages, Trivial changes to match the published versio

Dealloying of Platinum-Aluminum Thin Films Part II. Electrode Performance

Highly porous Pt/Al thin film electrodes on yttria stabilized zirconia electrolytes were prepared by dealloying of co-sputtered Pt/Al films. The oxygen reduction capability of the resulting electrodes was analyzed in a solid oxide fuel cell setup at elevated temperatures. During initial heating to 523 K exceptionally high performances compared to conventional Pt thin film electrodes were measured. This results from the high internal surface area and large three phase boundary length obtained by the dealloying process. Exposure to elevated temperatures of 673 K or 873 K gave rise to degradation of the electrode performance, which was primarily attributed to the oxidation of remaining Al in the thin films.Comment: 5 pages, 4 figure

D=7 / D=6 Heterotic Supergravity with Gauged R-Symmetry

We construct a family of chiral anomaly-free supergravity theories in D=6 starting from D=7 supergravity with a gauged noncompact R-symmetry, employing a Horava-Witten bulk-plus-boundary construction. The gauged noncompact R-symmetry yields a positive (de Sitter sign) D=6 scalar field potential. Classical anomaly inflow which is needed to cancel boundary-field loop anomalies requires careful consideration of the gravitational, gauge, mixed and local supersymmetry anomalies. Coupling of boundary hypermultiplets requires care with the Sp(1) gauge connection required to obtain quaternionic Kahler target manifolds in D=6. This class of gauged R-symmetry models may be of use as starting points for further compactifications to D=4 that take advantage of the positive scalar potential, such as those proposed in the scenario of supersymmetry in large extra dimensions.Comment: 43 pages, plain Latex; Clarification of discussion and references adde

A Call to Reflect on Evaluation Practices for Failure Detection in Image Classification

Reliable application of machine learning-based decision systems in the wild is one of the major challenges currently investigated by the field. A large portion of established approaches aims to detect erroneous predictions by means of assigning confidence scores. This confidence may be obtained by either quantifying the model's predictive uncertainty, learning explicit scoring functions, or assessing whether the input is in line with the training distribution. Curiously, while these approaches all state to address the same eventual goal of detecting failures of a classifier upon real-life application, they currently constitute largely separated research fields with individual evaluation protocols, which either exclude a substantial part of relevant methods or ignore large parts of relevant failure sources. In this work, we systematically reveal current pitfalls caused by these inconsistencies and derive requirements for a holistic and realistic evaluation of failure detection. To demonstrate the relevance of this unified perspective, we present a large-scale empirical study for the first time enabling benchmarking confidence scoring functions w.r.t all relevant methods and failure sources. The revelation of a simple softmax response baseline as the overall best performing method underlines the drastic shortcomings of current evaluation in the abundance of publicized research on confidence scoring. Code and trained models are at https://github.com/IML-DKFZ/fd-shifts

Brain Phosphorus Magnetic Resonance Spectroscopy Imaging of Sleep Homeostasis and Restoration in Drug Dependence

Numerous reports have documented a high occurrence of sleep difficulties in drug-dependent populations, prompting researchers to characterize sleep profiles and physiology in drug abusing populations. This mini-review examines studies indicating that drug-dependent populations exhibit alterations in sleep homeostatic and restoration processes in response to sleep deprivation. Sleep deprivation is a principal sleep research tool that results in marked physiological challenge, which provides a means to examine sleep homeostatic processes in response to extended wakefulness. A report from our laboratory demonstrated that following recovery sleep from sleep deprivation, brain high-energy phosphates particularly beta–nucleoside triphosphate (beta-NTP) are markedly increased as measured with phosphorus magnetic resonance spectroscopy (MRS). A more recent study examined the effects of sleep deprivation in opiate-dependent methadone-maintained (MM) subjects. The study demonstrated increases in brain beta-NTP following recovery sleep. Interestingly, these increases were of a markedly greater magnitude in MM subjects compared to control subjects. A similar study examined sleep deprivation in cocaine-dependent subjects demonstrating that cocaine-dependent subjects exhibit greater increases in brain beta-NTP following recovery sleep when compared to control subjects. The studies suggest that sleep deprivation in both MM subjects and cocaine-dependent subjects is characterized by greater changes in brain ATP levels than control subjects. Greater enhancements in brain ATP following recovery sleep may reflect a greater disruption to or impact of sleep deprivation in drug dependent subjects, whereby sleep restoration processes may be unable to properly regulate brain ATP and maintain brain high-energy equilibrium. These studies support the notion of a greater susceptibility to sleep loss in drug dependent populations. Additional sleep studies in drug abusing populations are needed, particularly those that examine potential differential effects of sleep deprivation