947 research outputs found
Is it time for studying real-life debiasing? Evaluation of the effectiveness of an analogical intervention technique.
The aim of this study was to initiate the exploration of debiasing methods applicable in real-life settings for achieving lasting improvement in decision making competence regarding multiple decision biases. Here, we tested the potentials of the analogical encoding method for decision debiasing. The advantage of this method is that it can foster the transfer from learning abstract principles to improving behavioral performance. For the purpose of the study, we devised an analogical debiasing technique for 10 biases (covariation detection, insensitivity to sample size, base rate neglect, regression to the mean, outcome bias, sunk cost fallacy, framing effect, anchoring bias, overconfidence bias, planning fallacy) and assessed the susceptibility of the participants (N = 154) to these biases before and 4 weeks after the training. We also compared the effect of the analogical training to the effect of 'awareness training' and a 'no-training' control group. Results suggested improved performance of the analogical training group only on tasks where the violations of statistical principles are measured. The interpretation of these findings require further investigation, yet it is possible that analogical training may be the most effective in the case of learning abstract concepts, such as statistical principles, which are otherwise difficult to master. The study encourages a systematic research of debiasing trainings and the development of intervention assessment methods to measure the endurance of behavior change in decision debiasing
Family of solvable generalized random-matrix ensembles with unitary symmetry
We construct a very general family of characteristic functions describing
Random Matrix Ensembles (RME) having a global unitary invariance, and
containing an arbitrary, one-variable probability measure which we characterize
by a `spread function'. Various choices of the spread function lead to a
variety of possible generalized RMEs, which show deviations from the well-known
Gaussian RME originally proposed by Wigner. We obtain the correlation functions
of such generalized ensembles exactly, and show examples of how particular
choices of the spread function can describe ensembles with arbitrary eigenvalue
densities as well as critical ensembles with multifractality.Comment: 4 pages, to be published in Phys. Rev. E, Rapid Com
Power-law random walks
We present some new results about the distribution of a random walk whose
independent steps follow a Gaussian distribution with exponent
. In the case we show that a stochastic
representation of the point reached after steps of the walk can be
expressed explicitly for all . In the case we show that the random
walk can be interpreted as a projection of an isotropic random walk, i.e. a
random walk with fixed length steps and uniformly distributed directions.Comment: 5 pages, 4 figure
Some Physical Consequences of Abrupt Changes in the Multipole Moments of a Gravitating Body
The Barrab\`es-Israel theory of light-like shells in General Relativity is
used to show explicitly that in general a light-like shell is accompanied by an
impulsive gravitational wave. The gravitational wave is identified by its
Petrov Type N contribution to a Dirac delta-function term in the Weyl conformal
curvature tensor (with the delta-function singular on the null hypersurface
history of the wave and shell). An example is described in which an
asymptotically flat static vacuum Weyl space-time experiences a sudden change
across a null hypersurface in the multipole moments of its isolated axially
symmetric source. A light-like shell and an impulsive gravitational wave are
identified, both having the null hypersurface as history. The stress-energy in
the shell is dominated (at large distance from the source) by the jump in the
monopole moment (the mass) of the source with the jump in the quadrupole moment
mainly responsible for the stress being anisotropic. The gravitational wave
owes its existence principally to the jump in the quadrupole moment of the
source confirming what would be expected.Comment: 26 pages, tex, no figures, to appear in Phys.Rev.
Myosin and tropomyosin stabilize the conformation of formin-nucleated actin filaments
The conformational elasticity of the actin cytoskeleton is
essential for its versatile biological functions. Increasing
evidence supports that the interplay between the structural and
functional properties of actin filaments is finely regulated by
actin-binding proteins, however, the underlying mechanisms and
biological consequences are not completely understood. Previous
studies showed that the binding of formins to the barbed end
induces conformational transitions in actin filaments by making
them more flexible through long-range allosteric interactions.
These conformational changes are accompanied by altered
functional properties of the filaments. To get insight into the
conformational regulation of formin-nucleated actin structures,
in the present work we investigated in detail how binding
partners of formin-generated actin structures, myosin and
tropomyosin, affect the conformation of the formin-nucleated
actin filaments, using fluorescence spectroscopic approaches.
Time-dependent fluorescence anisotropy and temperature-dependent
Forster-type resonance energy transfer measurements revealed
that heavy meromyosin, similarly to tropomyosin, restores the
formin-induced effects and stabilizes the conformation of actin
filaments. The stabilizing effect of heavy meromyosin is
cooperative. The kinetic analysis revealed that despite the
qualitatively similar effects of heavy meromyosin and
tropomyosin on the conformational dynamics of actin filaments,
the mechanisms of the conformational transition is different for
the two proteins. Heavy meromyosin stabilizes the formin-
nucleated actin filaments in an apparently single-step reaction
upon binding, while the stabilization by tropomyosin occurs
after complex formation. These observations support the idea
that actin-binding proteins are key elements of the molecular
mechanisms that regulate the conformational and functional
diversity of actin filaments in living cells
Genomic Organization of Duplicated Major Histocompatibility Complex Class I Regions in Atlantic Salmon (Salmo Salar)
Background: We have previously identified associations between major histocompatibility complex(MHC) class I and resistance towards bacterial and viral pathogens in Atlantic salmon. To evaluate if onlyMHC or also closely linked genes contributed to the observed resistance we ventured into sequencing ofthe duplicated MHC class I regions of Atlantic salmon.Results: Nine BACs covering more than 500 kb of the two duplicated MHC class I regions of Atlanticsalmon were sequenced and the gene organizations characterized. Both regions contained the proteasomecomponents PSMB8, PSMB9, PSMB9-like and PSMB10 in addition to the transporter for antigen processingTAP2, as well as genes for KIFC1, ZBTB22, DAXX, TAPBP, BRD2, COL11A2, RXRB and SLC39A7. TheIA region contained the recently reported MHC class I Sasa-ULA locus residing approximately 50 kbupstream of the major Sasa-UBA locus. The duplicated class IB region contained an MHC class I locusresembling the rainbow trout UCA locus, but although transcribed it was a pseudogene. No other MHCclass I-like genes were detected in the two duplicated regions. Two allelic BACs spanning the UBA locushad 99.2% identity over 125 kb, while the IA region showed 82.5% identity over 136 kb to the IB region.The Atlantic salmon IB region had an insert of 220 kb in comparison to the IA region containing threechitin synthase genes.Conclusion: We have characterized the gene organization of more than 500 kb of the two duplicatedMHC class I regions in Atlantic salmon. Although Atlantic salmon and rainbow trout are closely related,the gene organization of their IB region has undergone extensive gene rearrangements. The Atlanticsalmon has only one class I UCA pseudogene in the IB region while trout contains the four MHC UCA, UDA,UEA and UFA class I loci. The large differences in gene content and most likely function of the salmon andtrout class IB region clearly argues that sequencing of salmon will not necessarily provide informationrelevant for trout and vice versa
BLUF Domain Function Does Not Require a Metastable Radical Intermediate State
BLUF
(blue light using flavin) domain proteins are an important
family of blue light-sensing proteins which control a wide variety
of functions in cells. The primary light-activated step in the BLUF
domain is not yet established. A number of experimental and theoretical
studies points to a role for photoinduced electron transfer (PET)
between a highly conserved tyrosine and the flavin chromophore to
form a radical intermediate state. Here we investigate the role of
PET in three different BLUF proteins, using ultrafast broadband transient
infrared spectroscopy. We characterize and identify infrared active
marker modes for excited and ground state species and use them to
record photochemical dynamics in the proteins. We also generate mutants
which unambiguously show PET and, through isotope labeling of the
protein and the chromophore, are able to assign modes characteristic
of both flavin and protein radical states. We find that these radical
intermediates are not observed in two of the three BLUF domains studied,
casting doubt on the importance of the formation of a population of
radical intermediates in the BLUF photocycle. Further, unnatural amino
acid mutagenesis is used to replace the conserved tyrosine with fluorotyrosines,
thus modifying the driving force for the proposed electron transfer
reaction; the rate changes observed are also not consistent with a
PET mechanism. Thus, while intermediates of PET reactions can be observed
in BLUF proteins they are not correlated with photoactivity, suggesting
that radical intermediates are not central to their operation. Alternative
nonradical pathways including a keto–enol tautomerization induced
by electronic excitation of the flavin ring are considered
Integrated random processes exhibiting long tails, finite moments and 1/f spectra
A dynamical model based on a continuous addition of colored shot noises is
presented. The resulting process is colored and non-Gaussian. A general
expression for the characteristic function of the process is obtained, which,
after a scaling assumption, takes on a form that is the basis of the results
derived in the rest of the paper. One of these is an expansion for the
cumulants, which are all finite, subject to mild conditions on the functions
defining the process. This is in contrast with the Levy distribution -which can
be obtained from our model in certain limits- which has no finite moments. The
evaluation of the power spectrum and the form of the probability density
function in the tails of the distribution shows that the model exhibits a 1/f
spectrum and long tails in a natural way. A careful analysis of the
characteristic function shows that it may be separated into a part representing
a Levy processes together with another part representing the deviation of our
model from the Levy process. This allows our process to be viewed as a
generalization of the Levy process which has finite moments.Comment: Revtex (aps), 15 pages, no figures. Submitted to Phys. Rev.
Quantum Zeno Effect and Light-Dark Periods for a Single Atom
The quantum Zeno effect (QZE) predicts a slow-down of the time development of
a system under rapidly repeated ideal measurements, and experimentally this was
tested for an ensemble of atoms using short laser pulses for non-selective
state measurements. Here we consider such pulses for selective measurements on
a single system. Each probe pulse will cause a burst of fluorescence or no
fluorescence. If the probe pulses were strictly ideal measurements, the QZE
would predict periods of fluorescence bursts alternating with periods of no
fluorescence (light and dark periods) which would become longer and longer with
increasing frequency of the measurements. The non-ideal character of the
measurements is taken into account by incorporating the laser pulses in the
interaction, and this is used to determine the corrections to the ideal case.
In the limit, when the time between the laser pulses goes to zero, no freezing
occurs but instead we show convergence to the familiar macroscopic light and
dark periods of the continuously driven Dehmelt system. An experiment of this
type should be feasible for a single atom or ion in a trapComment: 16 pages, LaTeX, a4.sty; to appear in J. Phys.
- …