Monocular tracking of the human arm in 3D: real-time implementation and experiments

We have developed a system capable of tracking a human arm in 3D and in real time. The system is based on a previously developed algorithm for 3D tracking which requires only a monocular view and no special markers on the body. In this paper we describe our real-time system and the insights gained from real-time experimentation

Two-parameter bifurcation analysis of the buck converter

This paper is concerned with the analysis of two-parameter bifurcation phenomena in the buck power converter. It is shown that the complex dynamics of the converter can be unfolded by considering higher codimension bifurcation points in two-parameter space. Specifically, standard smooth bifurcations are shown to merge with discontinuity-induced bifurcation (DIB) curves, giving rise to intricate bifurcation scenarios. The analytical results are compared with those obtained numerically, showing excellent agreement between the analytical predictions and the numerical observations. The existence of these two-parameter bifurcation phenomena involving DIBs and smooth bifurcations, predicted in [P. Kowalczyk et al., Internat. J. Bifur. Chaos Appl. Sci. Engrg., 16 (2006), pp. 601–629; A. Colombo and F. Dercole, SIAM J. Appl. Dyn. Syst., submitted], is confirmed in this important class of systems.Postprint (published version

Perspectivas críticas de los géneros de la literatura popular: policiaco y literatura especulativa en Hispanoamérica: Introducción

The present dossier proposes to establish a dialogue with recent critical and theoretical approaches through readings that address crime and speculative genre through a wide spectrum of perspectives, focusing on works by authors who claim their position in the traditions of detective fiction and speculative literature.El presente dossier propone establecer un diálogo con la recientes aproximaciones críticas y teóricas a través de lecturas que abordan el género policiaco y especulativo a través de un amplio espectro de perspectivas, centrándose en obras de autores/as que reivindican su posicionamiento en las tradiciones de las narrativas policíaca y de la literatura especulativa

On the use of information and infrastructure technologies for the smart city research in Europe: a survey

The Smart City paradigm has become one of the most important research topics around the globe. Particularly in Europe, it is considered as a solution for unstoppable increase of high density urban environments and the European Commission has included the Smart City research as one of the key objectives for the FP7 (Seventh Framework Program) and H2020 (Horizon 2020) research initiatives. As a result, a considerable amount of quality research, with particular emphasis on information and communication technologies, has been produced. In this paper, we review the current efforts dedicated in Europe to this research topic. Particular attention is paid in the review to the platforms and infrastructure technologies adopted to introduce the Internet of Things into the city, taking into account the constraints and harshness of urban environments. Furthermore, this paper also considers the efforts in the experimental perspective, which includes the review of existing Smart City testbeds, part of wider European initiatives such as FIRE (Future Internet Research and Experimentation) and FIWARE. Last but not least, the main efforts in providing interoperability between the different experimental facilities are also presented.This work was funded in part by the European Union’s Horizon 2020 Programme of the FESTIVAL project (Federated Interoperable Smart ICT Services Development and Testing Platforms) under grant agreement 643275, and from the Japanese National Institute of Information and Communications Technology

Measurement of the cosmic ray spectrum above 4×10184{\times}10^{18} eV using inclined events detected with the Pierre Auger Observatory

A measurement of the cosmic-ray spectrum for energies exceeding $4{\times}10^{18}$ eV is presented, which is based on the analysis of showers with zenith angles greater than $60^{\circ}$ detected with the Pierre Auger Observatory between 1 January 2004 and 31 December 2013. The measured spectrum confirms a flux suppression at the highest energies. Above $5.3{\times}10^{18}$ eV, the "ankle", the flux can be described by a power law $E^{-\gamma}$ with index $\gamma=2.70 \pm 0.02 \,\text{(stat)} \pm 0.1\,\text{(sys)}$ followed by a smooth suppression region. For the energy ($E_\text{s}$) at which the spectral flux has fallen to one-half of its extrapolated value in the absence of suppression, we find $E_\text{s}=(5.12\pm0.25\,\text{(stat)}^{+1.0}_{-1.2}\,\text{(sys)}){\times}10^{19}$ eV.Comment: Replaced with published version. Added journal reference and DO

A reverse-engineering approach to dissect post-translational modulators of transcription factor's activity from transcriptional data.

BACKGROUND: Transcription factors (TFs) act downstream of the major signalling pathways functioning as master regulators of cell fate. Their activity is tightly regulated at the transcriptional, post-transcriptional and post-translational level. Proteins modifying TF activity are not easily identified by experimental high-throughput methods. RESULTS: We developed a computational strategy, called Differential Multi-Information (DMI), to infer post-translational modulators of a transcription factor from a compendium of gene expression profiles (GEPs). DMI is built on the hypothesis that the modulator of a TF (i.e. kinase/phosphatases), when expressed in the cell, will cause the TF target genes to be co-expressed. On the contrary, when the modulator is not expressed, the TF will be inactive resulting in a loss of co-regulation across its target genes. DMI detects the occurrence of changes in target gene co-regulation for each candidate modulator, using a measure called Multi-Information. We validated the DMI approach on a compendium of 5,372 GEPs showing its predictive ability in correctly identifying kinases regulating the activity of 14 different transcription factors. CONCLUSIONS: DMI can be used in combination with experimental approaches as high-throughput screening to efficiently improve both pathway and target discovery. An on-line web-tool enabling the user to use DMI to identify post-transcriptional modulators of a transcription factor of interest che be found at http://dmi.tigem.it

Energy Estimation of Cosmic Rays with the Engineering Radio Array of the Pierre Auger Observatory

The Auger Engineering Radio Array (AERA) is part of the Pierre Auger Observatory and is used to detect the radio emission of cosmic-ray air showers. These observations are compared to the data of the surface detector stations of the Observatory, which provide well-calibrated information on the cosmic-ray energies and arrival directions. The response of the radio stations in the 30 to 80 MHz regime has been thoroughly calibrated to enable the reconstruction of the incoming electric field. For the latter, the energy deposit per area is determined from the radio pulses at each observer position and is interpolated using a two-dimensional function that takes into account signal asymmetries due to interference between the geomagnetic and charge-excess emission components. The spatial integral over the signal distribution gives a direct measurement of the energy transferred from the primary cosmic ray into radio emission in the AERA frequency range. We measure 15.8 MeV of radiation energy for a 1 EeV air shower arriving perpendicularly to the geomagnetic field. This radiation energy -- corrected for geometrical effects -- is used as a cosmic-ray energy estimator. Performing an absolute energy calibration against the surface-detector information, we observe that this radio-energy estimator scales quadratically with the cosmic-ray energy as expected for coherent emission. We find an energy resolution of the radio reconstruction of 22% for the data set and 17% for a high-quality subset containing only events with at least five radio stations with signal.Comment: Replaced with published version. Added journal reference and DO

Measurement of the Radiation Energy in the Radio Signal of Extensive Air Showers as a Universal Estimator of Cosmic-Ray Energy

We measure the energy emitted by extensive air showers in the form of radio emission in the frequency range from 30 to 80 MHz. Exploiting the accurate energy scale of the Pierre Auger Observatory, we obtain a radiation energy of 15.8 \pm 0.7 (stat) \pm 6.7 (sys) MeV for cosmic rays with an energy of 1 EeV arriving perpendicularly to a geomagnetic field of 0.24 G, scaling quadratically with the cosmic-ray energy. A comparison with predictions from state-of-the-art first-principle calculations shows agreement with our measurement. The radiation energy provides direct access to the calorimetric energy in the electromagnetic cascade of extensive air showers. Comparison with our result thus allows the direct calibration of any cosmic-ray radio detector against the well-established energy scale of the Pierre Auger Observatory.Comment: Replaced with published version. Added journal reference and DOI. Supplemental material in the ancillary file

Human Transgene-Free Amniotic-Fluid-Derived Induced Pluripotent Stem Cells for Autologous Cell Therapy

The establishment of a reliable prenatal source of autologous, transgene-free progenitor cells has enormous potential in the development of regenerative-medicine-based therapies for infants born with devastating birth defects. Here, we show that a largely CD117-negative population of human amniotic fluid mesenchymal stromal cells (AF-MSCs) obtained from fetuses with or without prenatally diagnosed anomalies are readily abundant and have limited baseline differentiation potential when compared with bone-marrow-derived MSCs and other somatic cell types. Nonetheless, the AF-MSCs could be easily reprogrammed into induced pluripotent stem cells (iPSCs) using nonintegrating Sendai viral vectors encoding for OCT4, SOX2, KLF4, and cMYC. The iPSCs were virtually indistinguishable from human embryonic stem cells in multiple assays and could be used to generate a relatively homogeneous population of neural progenitors, expressing PAX6, SOX2, SOX3, Musashi-1, and PSA-NCAM, for potential use in neurologic diseases. Further, these neural progenitors showed engraftment potential in vivo and were capable of differentiating into mature neurons and astrocytes in vitro. This study demonstrates the usefulness of AF-MSCs as an excellent source for the generation of human transgene-free iPSCs ideally suited for autologous perinatal regenerative medicine applications.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140204/1/scd.2014.0110.pd