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The microbiome in patients with atopic dermatitis.
As an interface with the environment, the skin is a complex ecosystem colonized by many microorganisms that coexist in an established balance. The cutaneous microbiome inhibits colonization with pathogens, such as Staphylococcus aureus, and is a crucial component for function of the epidermal barrier. Moreover, crosstalk between commensals and the immune system is now recognized because microorganisms can modulate both innate and adaptive immune responses. Host-commensal interactions also have an effect on the developing immune system in infants and, subsequently, the occurrence of diseases, such as asthma and atopic dermatitis (AD). Later in life, the cutaneous microbiome contributes to the development and course of skin disease. Accordingly, in patients with AD, a decrease in microbiome diversity correlates with disease severity and increased colonization with pathogenic bacteria, such as S aureus. Early clinical studies suggest that topical application of commensal organisms (eg, Staphylococcus hominis or Roseomonas mucosa) reduces AD severity, which supports an important role for commensals in decreasing S aureus colonization in patients with AD. Advancing knowledge of the cutaneous microbiome and its function in modulating the course of skin disorders, such as AD, might result in novel therapeutic strategies
Presbyopic LASIK using hybrid bi-aspheric micro-monovision ablation profile for presbyopic corneal treatments.
PURPOSE: To evaluate distance and near image quality after hybrid bi-aspheric multifocal central presbyLASIK treatments. DESIGN: Consecutive case series. METHODS: Sixty-four eyes of 32 patients consecutively treated with central presbyLASIK were assessed. The mean age of the patients was 51 ± 3 years with a mean spherical equivalent refraction of -1.08 ± 2.62 diopters (D) and mean astigmatism of 0.52 ± 0.42 D. Monocular corrected distance visual acuity (CDVA), corrected near visual acuity (CNVA), and distance corrected near visual acuity (DCNVA) of nondominant eyes; binocular uncorrected distance visual acuity (UDVA); uncorrected intermediate visual acuity (UIVA); distance corrected intermediate visual acuity (DCIVA); and uncorrected near visual acuity (UNVA) were assessed pre- and postoperatively. Subjective quality of vision and near vision was assessed using the 10-item Rasch-scaled Quality of Vision and Near Activity Visual Questionnaire, respectively. RESULTS: At 1 year postoperatively, 93% of patients achieved 20/20 or better binocular UDVA; 90% and 97% of patients had J2 or better UNVA and UIVA, respectively; 7% lost 2 Snellen lines of CDVA; Strehl ratio reduced by ∼-4% ± 14%. Defocus curves revealed a loss of half a Snellen line at best focus, with no change for intermediate vergence (-1.25 D) and a mean gain of 2 lines for near vergence (-3 D). CONCLUSIONS: Presbyopic treatment using a hybrid bi-aspheric micro-monovision ablation profile is safe and efficacious. The postoperative outcomes indicate improvements in binocular vision at far, intermediate, and near distances with improved contrast sensitivity. A 19% retreatment rate should be considered to increase satisfaction levels, besides a 3% reversal rate
Identifying Planetary Biosignature Impostors: Spectral Features of CO and O4 Resulting from Abiotic O2/O3 Production
O2 and O3 have been long considered the most robust individual biosignature
gases in a planetary atmosphere, yet multiple mechanisms that may produce them
in the absence of life have been described. However, these abiotic planetary
mechanisms modify the environment in potentially identifiable ways. Here we
briefly discuss two of the most detectable spectral discriminants for abiotic
O2/O3: CO and O4. We produce the first explicit self-consistent simulations of
these spectral discriminants as they may be seen by JWST. If JWST-NIRISS and/or
NIRSpec observe CO (2.35, 4.6 um) in conjunction with CO2 (1.6, 2.0, 4.3 um) in
the transmission spectrum of a terrestrial planet it could indicate robust CO2
photolysis and suggest that a future detection of O2 or O3 might not be
biogenic. Strong O4 bands seen in transmission at 1.06 and 1.27 um could be
diagnostic of a post-runaway O2-dominated atmosphere from massive H-escape. We
find that for these false positive scenarios, CO at 2.35 um, CO2 at 2.0 and 4.3
um, and O4 at 1.27 um are all stronger features in transmission than O2/O3 and
could be detected with SNRs 3 for an Earth-size planet orbiting a
nearby M dwarf star with as few as 10 transits, assuming photon-limited noise.
O4 bands could also be sought in UV/VIS/NIR reflected light (at 0.345, 0.36,
0.38, 0.445, 0.475, 0.53, 0.57, 0.63, 1.06, and 1.27 um) by a next generation
direct-imaging telescope such as LUVOIR/HDST or HabEx and would indicate an
oxygen atmosphere too massive to be biologically produced.Comment: 7 pages, 4 figures, accepted to the Astrophysical Journal Letter
Activity of different desoximetasone preparations compared to other topical corticosteroids in the vasoconstriction assay
Introduction: We report on a double-blind, vehicle-controlled, single-center confirmatory study with random assignment. The purpose of the study was to investigate the topical bioavailability of different topical corticosteroid formulations in healthy human beings focussing on desoximetasone (DM). Materials and Methods: Two DM 0.25% formulations {[}ointment (DM-o) and fatty ointment (DM-fo, water-free); class III corticosteroids], the corresponding active ingredient-free vehicles and three comparators of different strength {[}clobetasol propionate 0.05% (CP 0.05%), fatty ointment, class IV; hydrocortisone (HC) 1%, fatty ointment, class I, and betamethasone (BM) 0.05%, fatty ointment, class III] were tested using the vasoconstriction assay. The degree of vasoconstriction (blanching) in the treatment field was compared to the one found in untreated control fields using chromametric measurements and clinical assessment. Results/Conclusion: DM-o 0.25%, DM-fo 0.25% and BM 0.05% showed similar vasoconstrictive potential, i.e., clear blanching. In fact, both DM preparations were proven to be non-inferior to BM 0.05%, while CP 0.05% was found a little less active. HC 1.0% and the DM vehicles showed no clear-cut vasoconstrictive effect. No adverse events related to the study medications were observed. Good topical bioavailability of both DM formulations was detected by chromametric measurement and clinical assessment. Copyright (C) 2008 S. Karger AG, Basel
Polymer reptation and nucleosome repositioning
We consider how beads can diffuse along a chain that wraps them, without
becoming displaced from the chain; our proposed mechanism is analogous to the
reptation of "stored length" in more familiar situations of polymer dynamics.
The problem arises in the case of globular aggregates of proteins (histones)
that are wound by DNA in the chromosomes of plants and animals; these beads
(nucleosomes) are multiply wrapped and yet are able to reposition themselves
over long distances, while remaining bound by the DNA chain.Comment: 9 pages, including 2 figures, to be published in Phys. Rev. Let
VPLanet: The Virtual Planet Simulator
We describe a software package called VPLanet that simulates fundamental
aspects of planetary system evolution over Gyr timescales, with a focus on
investigating habitable worlds. In this initial release, eleven physics modules
are included that model internal, atmospheric, rotational, orbital, stellar,
and galactic processes. Many of these modules can be coupled simultaneously to
simulate the evolution of terrestrial planets, gaseous planets, and stars. The
code is validated by reproducing a selection of observations and past results.
VPLanet is written in C and designed so that the user can choose the physics
modules to apply to an individual object at runtime without recompiling, i.e.,
a single executable can simulate the diverse phenomena that are relevant to a
wide range of planetary and stellar systems. This feature is enabled by
matrices and vectors of function pointers that are dynamically allocated and
populated based on user input. The speed and modularity of VPLanet enables
large parameter sweeps and the versatility to add/remove physical phenomena to
assess their importance. VPLanet is publicly available from a repository that
contains extensive documentation, numerous examples, Python scripts for
plotting and data management, and infrastructure for community input and future
development.Comment: 75 pages, 34 figures, 10 tables, accepted to the Proceedings of the
Astronomical Society of the Pacific. Source code, documentation, and examples
available at https://github.com/VirtualPlanetaryLaboratory/vplane
N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methoxybenzamide
In the title compound, C16H11F3N2O2, the carboxamide group connecting the two aromatic rings is in a syn-periplanar configuration; the molecule is non-planar; the dihedral angle between the two aromatic rings is 13.95 (18)°. Intramolecular N—H⋯O and C—H⋯O hydrogen bonds occur. In the crystal, molecules are linked by intermolecular C—H⋯O hydrogen bonds
Optimizing Multi-Photon Fluorescence Microscopy Light Collection from Living Tissue by Non-Contact Total Emission Detection (TEDII)
Farrando Sicilia, Jordi; Fuente Fuente, Carlo
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