Abundant Methanol Masers but no New Evidence for Star Formation in GCM0.253+0.016

We present new observations of the quiescent giant molecular cloud GCM0.253+0.016 in the Galactic center, using the upgraded Karl G. Jansky Very Large Array. Observations were made at wavelengths near 1 cm, at K (24 to 26 GHz) and Ka (27 and 36 GHz) bands, with velocity resolutions of 1-3 km/s and spatial resolutions of ~0.1 pc, at the assumed 8.4 kpc distance of this cloud. The continuum observations of this cloud are the most sensitive yet made, and reveal previously undetected emission which we attribute primarily to free-free emission from external ionization of the cloud. In addition to the sensitive continuum map, we produce maps of 12 molecular lines: 8 transitions of NH3 -- (1,1),(2,2),(3,3),(4,4),(5,5),(6,6),(7,7) and (9,9), as well as the HC3N (3-2) and (4-3) lines, and CH3OH 4(-1) - 3(0) the latter of which is known to be a collisionally-excited maser. We identify 148 CH3OH 4(-1) - 3(0) (36.2 GHz) sources, of which 68 have brightness temperatures in excess of the highest temperature measured for this cloud (400 K) and can be confirmed to be masers. The majority of these masers are concentrated in the southernmost part of the cloud. We find that neither these masers nor the continuum emission in this cloud provide strong evidence for ongoing star formation in excess of that previously inferred by the presence of an H2O maser.Comment: 33 pages, 4 tables, 9 figures; ApJ Accepte

A 610-MHz Galactic Plane Pulsar Search with the Giant Meterwave Radio Telescope

We report on the discovery of three new pulsars in the first blind survey of the north Galactic plane (45 < l < 135 ; |b| < 1) with the Giant Meterwave Radio telescope (GMRT) at an intermediate frequency of 610 MHz. The timing parameters, obtained in follow up observations with the Lovell Telescope at Jodrell Bank Observatory and the GMRT, are presented.Comment: 2 pages, 1 figure, to be published in conference proceedings of "40 years of pulsars ..", replaced figure

The Threat of Plant Toxins and Bioterrorism: A Review

The intentional use of highly pathogenic microorganisms, such as bacteria, viruses or their toxins, to spread mass-scale diseases that destabilize populations (with motivations of religious or ideological belief, monetary implications, or political decisions) is defined as bioterrorism. Although the success of a bioterrorism attack is not very realistic due to technical constraints, it is not unlikely and the threat of such an attack is higher than ever before. It is now a fact that the capability to create panic has allured terrorists for the use of biological agents (BAs) to cause terror attacks. In the era of biotechnology and nanotechnology, accessibility in terms of price and availability has spread fast, with new sophisticated BAs often being produced and used. Moreover, there are some BAs that are becoming increasingly important, such as toxins produced by bacteria (e.g., Botulinum toxin, BTX), or Enterotoxyn type B, also known as Staphylococcal Enterotoxin B (SEB)) and extractions from plants. The most increasing records are with regards to the extraction / production of ricin, abrin, modeccin, viscumin and volkensin, which are the most lethal plant toxins known to humans, even in low amounts. Moreover, ricin was also developed as an aerosol biological warfare agent (BWA) by the US and its allies during World War II, but was never used. Nowadays, there are increasing records that show how easy it can be to extract plant toxins and transform them into biological weapon agents (BWAs), regardless of the scale of the group of individuals

Effects of ionizing radiation on flora ten years after the Fukushima Dai-ichi disaster

: The aim of this work is to analyze the effects of ionizing radiation and radionuclides (like 137Cs) in several higher plants located around the Fukushima Dai-ichi Nuclear Power Plant (FNPP), evaluating both their adaptive processes and evolution. After the FNPP accident in March 2011 much attention was focused to the biological consequences of ionizing radiation and radionuclides released in the area surrounding the nuclear plant. This unexpected mishap led to the emission of radionuclides in aerosol and gaseous forms from the power plant, which contaminated a large area, including wild forest, cities, farmlands, mountains, and the sea, causing serious problems. Large quantities of 131I, 137Cs, and 134Cs were detected in the fallout. People were evacuated but the flora continued to be affected by the radiation exposure and by the radioactive dusts' fallout. The response of biota to FNPP irradiation was a complex interaction among radiation dose, dose rate, temporal and spatial variation, varying radiation sensitivities of the different plants' species, and indirect effects from other events. The repeated ionizing radiations, acute or chronic, guarantee an adaptation of the plant species, demonstrating a radio-resistance. Consequently, ionizing radiation affects the genetic structure, especially during chronic irradiation, reducing genetic variability. This reduction is associated with the different susceptibility of plant species to chronic stress. This would confirm the adaptive theory associated with this phenomenon. The effects that ionizing radiation has on different life forms are examined in this review using the FNPP disaster as a case study focusing the attention ten years after the accident

A compact light readout system for longitudinally segmented shashlik calorimeters

The longitudinal segmentation of shashlik calorimeters is challenged by dead zones and non-uniformities introduced by the light collection and readout system. This limitation can be overcome by direct fiber-photosensor coupling, avoiding routing and bundling of the wavelength shifter fibers and embedding ultra-compact photosensors (SiPMs) in the bulk of the calorimeter. We present the first experimental test of this readout scheme performed at the CERN PS-T9 beamline in 2015 with negative particles in the 1-5~GeV energy range. In this paper, we demonstrate that the scheme does not compromise the energy resolution and linearity compared with standard light collection and readout systems. In addition, we study the performance of the calorimeter for partially contained charged hadrons to assess the $e/\pi$ separation capability and the response of the photosensors to direct ionization.Comment: To appear in Nuclear Instruments and Methods in Physics Research,

Cytogenetic bio-dosimetry techniques in the detection of dicentric chromosomes induced by ionizing radiation: A review

Ionizing radiation is ubiquitous in the environment. Its source can be natural, such as radioactive materials present in soil and cosmic rays, or artificial, such as the fuel for nuclear power plants. Overexposure to ionizing radiation may damage living tissue and could cause severe health problems (i.e., mutations, radiation sickness, cancer, and death). Cytogenetic bio-dosimetry has the great advantage to take into account the inter-individual variation, and it is informative even when physical dosimetry is not applicable; moreover, it is the definitive method to assess exposure to ionizing radiation recommended by the World Health Organization (WHO). Such a procedure involves counting the frequency of dicentric chromosomes (DCs), which are the most studied chromosomal aberrations used as absorbed radiation biomarkers, during the metaphase of cells. A set of algorithms, tested on different programming languages to automatically identify DCs, is analyzed by the authors together with an Automated Dicentric Chromosome Identifying software (ADCI) mostly based on OpenCV programming libraries. The purpose of this work is to review the main results regarding the correlation between ionizing radiation and dicentric chromosomes in cytogenetic bio-dosimetry

Discovery of three new pulsars in a 610 MHz pulsar survey with the GMRT

We report on the discovery of three new pulsars in the first blind survey of the north Galactic plane (45 degrees < l < 135 degrees; |b| < 1 degrees with the Giant Meterwave Radio telescope (GMRT) at an intermediate frequency of 610 MHz. The survey covered 106 square degrees with a sensitivity of roughly 1 mJy to long-period pulsars (pulsars with period longer than 1 s). The three new pulsars have periods of 318, 933, and 1056 ms. Their timing parameters and flux densities, obtained in follow up observations with the Lovell Telescope at Jodrell Bank and the GMRT, are presented. We also report on pulse nulling behaviour in one of the newly discovered pulsars, PSR J2208+5500.Comment: Accepted for publication in MNRAS, 7 pages, 5 figures, 2 table

Predictive value of VEGF gene polymorphisms for metastatic colorectal cancer patients receiving first-line treatment including fluorouracil, irinotecan, and bevacizumab

The aim of this study is to evaluate the influence of germline vascular endothelial growth factor (VEGF) gene polymorphisms (VGPs) on the efficacy of the anti-VEGF antibody bevacizumab (Bev) in metastatic colorectal cancer (MCRC) patients