508 research outputs found
Full phase stabilization of a Yb:fiber femtosecond frequency comb via high-bandwidth transducers
We present full phase stabilization of an amplified Yb:fiber femtosecond
frequency comb using an intra-cavity electro-optic modulator and an
acousto-optic modulator. These transducers provide high servo bandwidths of 580
kHz and 250 kHz for frep and fceo, producing a robust and low phase noise fiber
frequency comb. The comb was self-referenced with an f - 2f interferometer and
phase locked to an ultra-stable optical reference used for the JILA Sr optical
clock at 698 nm, exhibiting 0.21 rad and 0.47 rad of integrated phase errors
(over 1 mHz - 1 MHz) respectively. Alternatively, the comb was locked to two
optical references at 698 nm and 1064 nm, obtaining 0.43 rad and 0.14 rad of
integrated phase errors respectively
New classes of exact solutions of three-dimensional Navier-Stokes equations
New classes of exact solutions of the three-dimensional unsteady
Navier-Stokes equations containing arbitrary functions and parameters are
described. Various periodic and other solutions, which are expressed through
elementary functions are obtained. The general physical interpretation and
classification of solutions is given.Comment: 11 page
Quantum Computing and Quantum Simulation with Group-II Atoms
Recent experimental progress in controlling neutral group-II atoms for
optical clocks, and in the production of degenerate gases with group-II atoms
has given rise to novel opportunities to address challenges in quantum
computing and quantum simulation. In these systems, it is possible to encode
qubits in nuclear spin states, which are decoupled from the electronic state in
the S ground state and the long-lived P metastable state on the
clock transition. This leads to quantum computing scenarios where qubits are
stored in long lived nuclear spin states, while electronic states can be
accessed independently, for cooling of the atoms, as well as manipulation and
readout of the qubits. The high nuclear spin in some fermionic isotopes also
offers opportunities for the encoding of multiple qubits on a single atom, as
well as providing an opportunity for studying many-body physics in systems with
a high spin symmetry. Here we review recent experimental and theoretical
progress in these areas, and summarise the advantages and challenges for
quantum computing and quantum simulation with group-II atoms.Comment: 11 pages, 7 figures, review for special issue of "Quantum Information
Processing" on "Quantum Information with Neutral Particles
Modern microwave methods in solid state inorganic materials chemistry: from fundamentals to manufacturing
No abstract available
Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation and death
The purinergic signalling system, which uses purines and pyrimidines as chemical transmitters, and purinoceptors as effectors, is deeply rooted in evolution and development and is a pivotal factor in cell communication. The ATP and its derivatives function as a 'danger signal' in the most primitive forms of life. Purinoceptors are extraordinarily widely distributed in all cell types and tissues and they are involved in the regulation of an even more extraordinary number of biological processes. In addition to fast purinergic signalling in neurotransmission, neuromodulation and secretion, there is long-term (trophic) purinergic signalling involving cell proliferation, differentiation, motility and death in the development and regeneration of most systems of the body. In this article, we focus on the latter in the immune/defence system, in stratified epithelia in visceral organs and skin, embryological development, bone formation and resorption, as well as in cancer. Cell Death and Disease (2010) 1, e9; doi:10.1038/cddis.2009.11; published online 14 January 201
Coherence of Spin-Polarized Fermions Interacting with a Clock Laser in a Stark-Shift-Free Optical Lattice
We investigated the coherence of spin-polarized ^{87}Sr atoms trapped in a
light-shift-free one-dimensional optical lattice during their interaction with
a clock laser on the ^1S_0-^3P_0 transition. Collapses and revivals appeared
for more than 50 Rabi cycles, attributed to the thermal distribution of
discrete vibrational states in the lattice potential. The population
oscillation in the clock states lasted more than 1s, demonstrating high
immunity from decoherence. This long atomic coherence suggests the feasibility
of Pauli blocking of collisions in optical clock excitation.Comment: 10 pages, 4 figure
NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer
Alternative splicing is dysregulated in cancer and the reactivation of telomerase involves the splicing of TERT transcripts to produce full-length (FL) TERT. Knowledge about the splicing factors that enhance or silence FL hTERT is lacking. We identified splicing factors that reduced telomerase activity and shortened telomeres using a siRNA minigene reporter screen and a lung cancer cell bioinformatics approach. A lead candidate, NOVA1, when knocked down resulted in a shift in hTERT splicing to non-catalytic isoforms, reduced telomerase activity, and progressive telomere shortening. NOVA1 knockdown also significantly altered cancer cell growth in vitro and in xenografts. Genome engineering experiments reveal that NOVA1 promotes the inclusion of exons in the reverse transcriptase domain of hTERT resulting in the production of FL hTERT transcripts. Utilizing hTERT splicing as a model splicing event in cancer may provide new insights into potentially targetable dysregulated splicing factors in cancer
Telomerase expression and telomere length in breast cancer and their associations with adjuvant treatment and disease outcome
Loss of functional pRB is not a ubiquitous feature of B-cell malignancies
Human cancers frequently sustain genetic mutations that alter the function of their G1 cell cycle control check point. These include changes to the retinoblastoma gene and to the genes that regulate its phosphorylation, such as the cyclin-dependent kinase inhibitor p16(INK4a). Altered expression of retinoblastoma protein (pRb) is associated with non-Hodgkin's lymphoma, particularly centroblastic and Burkitt's lymphomas. pRb is expressed in normal B-cells and its regulatory phosphorylation pathway is activated in response to a variety of stimuli. Since human B-lymphoma-derived cell lines are often used as in vitro model systems to analyse the downstream effects of signal transduction, we examined the functional status of pRb in a panel of human B-cell lines. We identified eleven cell lines which express the hyperphosphorylated forms of pRb. Furthermore, we suggest that the pRb protein appears to be functional in these cell lines
Activation of PyMT in β Cells Induces Irreversible Hyperplasia, but Oncogene-Dependent Acinar Cell Carcinomas When Activated in Pancreatic Progenitors
It is unclear whether the cellular origin of various forms of pancreatic cancer involves transformation or transdifferentiation of different target cells or whether tumors arise from common precursors, with tumor types determined by the specific genetic alterations. Previous studies suggested that pancreatic ductal carcinomas might be induced by polyoma middle T antigen (PyMT) expressed in non-ductal cells. To ask whether PyMT transforms and transdifferentiates endocrine cells toward exocrine tumor phenotypes, we generated transgenic mice that carry tetracycline-inducible PyMT and a linked luciferase reporter. Induction of PyMT in β cells causes β-cell hyperplastic lesions that do not progress to malignant neoplasms. When PyMT is de-induced, β cell proliferation and growth cease; however, regression does not occur, suggesting that continued production of PyMT is not required to maintain the viable expanded β cell population. In contrast, induction of PyMT in early pancreatic progenitor cells under the control of Pdx1 produces acinar cell carcinomas and β-cell hyperplasia. The survival of acinar tumor cells is dependent on continued expression of PyMT. Our findings indicate that PyMT can induce exocrine tumors from pancreatic progenitor cells, but cells in the β cell lineage are not transdifferentiated toward exocrine cell types by PyMT; instead, they undergo oncogene-dependent hyperplastic growth, but do not require PyMT for survival
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