Pengaruh Kualitas Produk terhadap Keputusan Pembelian Sepeda Motor Honda Beat pada CV. LION di Ternate

In line with his rapid development of science and technology which experienced an increase and change over time underwent logical consequences for the business world by shifting his values to the demands of human needs and desires. This phenomenon brings implication to every company in maintaining the continuity of its operational activities, where the products / services produced are expected to be well received by consumers. Product quality is important in the successful marketing of products / services. Purchase decision is determined by many factors such as product quality that is the researcher\u27s attention with the assumption that if the quality of product is good then it will make the consumer interested so that make the consumer satisfied. This study aims to find out how far the quality of the product to the purchase decision Honda motor beat on CV. LION by taking 86 respondents. the method of analysis used in this research is quantitative method with approach correlation and simple regression, using questionnaires and observations as a technique in obtaining data. In the calculations in this study, researchers use SPSS software version 21. This can indicate whether there is a correlation between the two variables and how much influence the quality of the product to the purchase decision. The result of this research shows that product quality has negative effect on purchasing decision because negative regression coefficient value is 21,608 and every 1% increase of service quality (X), then purchasing decision (Y) will increase by 0,479

Pengaplikasian Lumpur Sidoarjo Kadar Tinggi Pada Mortar Dan Beton

Berbagaipenelitian mengenai pemanfaatan material lumpur Sidoarjo, khususnya sebagai material pengganti semen (pozzolan) telah dilakukan. Penelitian ini berfokus pada penggunaan lumpur Sidoarjo dengan kadar yang tinggi, yaitu >50%, serta membandingkan hasil tersebut dengan fly ash. Analisa terhadap materialdilakukan menggunakan XRF (X-Ray Flouresence) untuk mengetahui karakteristik dari material tersebut. Analisa juga dilakukan terhadap pengaruh ukuran butiranmenggunakan PSA (Particle Size Analysis).Lumpur dilakukan treatment dari pengeringan, pembakaran hingga digiling menggunakan bar-mill dengan lama penggilingan bervariasi untuk mendapatkan ukuran butiran berbeda. Presentase kadar yang digunakan adalah 50%, 55% dan 60% dari total cementitious material. Mortar dan beton digunakan ukuran 5x5x5 cm3 dan 15x15x15 cm3 lalu dilakukan pengujian berupa kuat tekan, workability dan setting time. Hasil menunjukkan semakin halus ukuran butiran, semakin tinggi kuat tekan dan workability-nya. Diantara kadar 50%-60% penggantian semen dengan lumpur Sidoarjo, kadar 50% merupakan yang paling efektif.Pada beton dengan lumpur Sidoarjo menghasilkan slump test sebesar 8,5 cm dengan kuat tekan 34,07 MPa pada umur 37 hari

Central Kalimantan's Fast Growing Species: Suitability for Pulp and Paper

Recent studies of fast growing species grown in PT. Sari Bumi Kusuma, Central Kalimantan, show that based on their fiber dimensions there are five species, namely Endospermum diadenum, Dillenia spp., Adinandra dumosa, Adiandra sp., and Nauclea junghuhnii with good potential for pulp and paper production. The fiber length of those five wood species are was more than 2,200 µm on average. This paper studies the physical properties, fiber dimensions and their chemical contents to predict the paper and pulp quality. The result shows that all of the species were classified in the medium to high density category. All species were classified into the first class quality for pulp and paper. Based on chemical contents, Dillenia sp. is the most suitable species due to its high value of holocellulose and a-cellulose, low lignin content, and its fiber length is about 3,119 µm on average. A. dumosa also has good opportunities because it had the longest fiber lengths (3,137 µm on average) and high value of holocellulose, even though it has the highest lignin content. While Nuclea junghuhnii is less suitable due to low values of holocellulose and a-cellulose

The cytokine temporal profile in rat cortex after controlled cortical impact

Cerebral inflammatory responses may initiate secondary cascades following traumatic brain injury (TBI). Changes in the expression of both cytokines and chemokines may activate, regulate, and recruit innate and adaptive immune cells associated with secondary degeneration, as well as alter a host of other cellular processes. In this study, we quantified the temporal expression of a large set of inflammatory mediators in rat cortical tissue after brain injury. Following a controlled cortical impact (CCI) on young adult male rats, cortical and hippocampal tissue of the injured hemisphere and matching contralateral material was harvested at early (4, 12, and 24 hours) and extended (3 and 7 days) time points post-procedure. Naïve rats that received only anesthesia were used as controls. Processed brain homogenates were assayed for chemokine and cytokine levels utilizing an electrochemiluminescence-based multiplex ELISA platform. The temporal profile of cortical tissue samples revealed a multi-phasic injury response following brain injury. CXCL1, IFN-γ, TNF-α levels significantly peaked at four hours post-injury compared to levels found in naïve or contralateral tissue. CXCL1, IFN-γ, and TNF-α levels were then observed to decrease at least 3-fold by 12 hours post-injury. IL-1β, IL-4, and IL-13 levels were also significantly elevated at four hours post-injury although their expression did not decrease more than 3-fold for up to 24 hours post-injury. Additionally, IL-1β and IL-4 levels displayed a biphasic temporal profile in response to injury, which may suggest their involvement in adaptive immune responses. Interestingly, peak levels of CCL2 and CCL20 were not observed until after four hours post-injury. CCL2 levels in injured cortical tissue were significantly higher than peak levels of any other inflammatory mediator measured, thus suggesting a possible use as a biomarker. Fully elucidating chemokine and cytokine signaling properties after brain injury may provide increased insight into a number of secondary cascade events that are initiated or regulated by inflammatory responses

Evaluation of Nigerian Waxy Crude Oil Using Rheological Models

This paper evaluates Nigerian Waxy Crude Oil using Bingham Plastic model and Power Law model. Laboratory measurements on rheology were carried out on the sample as per API standard at temperatures of 30oC and 50oC. The obtained data of shear rate and shear stress were regressed and plotted. The Bingham Plastic model gave the values of yield stress and the regression coefficient as 0.673lbs/100ft2 and 0.9996 at the temperatures of 30oC; 0.622lbs/100ft2 and 0.9986 at the temperature of 50oC. Also, the Power Law model gave zero yield stress and regression coefficient of 0.9737 and 0.9884 at both temperatures. From the result, Nigerian Waxy Crude Oil is more adequately predicted by Bingham Plastic model because of the exhibition of Plastic behavior of a higher regression coefficien

Prevention of elastase-induced emphysema in placenta growth factor knock-out mice

<p>Abstract</p> <p>Background</p> <p>Although both animal and human studies suggested the association between placenta growth factor (PlGF) and chronic obstructive pulmonary disease (COPD), especially lung emphysema, the role of PlGF in the pathogenesis of emphysema remains to be clarified. This study hypothesizes that blocking PlGF prevents the development of emphysema.</p> <p>Methods</p> <p>Pulmonary emphysema was induced in PlGF knock-out (KO) and wild type (WT) mice by intra-tracheal instillation of porcine pancreatic elastase (PPE). A group of KO mice was then treated with exogenous PlGF and WT mice with neutralizing anti-VEGFR1 antibody. Tumor necrosis factor alpha (TNF-α), matrix metalloproteinase-9 (MMP-9), and VEGF were quantified. Apoptosis measurement and immuno-histochemical staining for VEGF R1 and R2 were performed in emphysematous lung tissues.</p> <p>Results</p> <p>After 4 weeks of PPE instillation, lung airspaces enlarged more significantly in WT than in KO mice. The levels of TNF-α and MMP-9, but not VEGF, increased in the lungs of WT compared with those of KO mice. There was also increased in apoptosis of alveolar septal cells in WT mice. Instillation of exogenous PlGF in KO mice restored the emphysematous changes. The expression of both VEGF R1 and R2 decreased in the emphysematous lungs.</p> <p>Conclusion</p> <p>In this animal model, pulmonary emphysema is prevented by depleting PlGF. When exogenous PlGF is administered to PlGF KO mice, emphysema re-develops, implying that PlGF contributes to the pathogenesis of emphysema.</p

A BURST-BAUS consensus document for best practice in the conduct of scrotal exploration for suspected testicular torsion : the Finding consensus for orchIdopeXy In Torsion (FIX-IT) study

Acknowledgements The authors would like to thank Jacqueline Emkes and Rachel Jury for their contribution to our protocol development with respect to patient and public involvement. Similarly, the authors would like to thank Dr Matthew Coward, Department of Urology, University of North Carolina, and Dr Selcuk Sarikaya, Department of Urology, University of Ankara, for their international perspectives and input to our study protocol. We would like to acknowledge the BAUS Trustees for allowing this collaboration. Unrelated to this work, The BURST Research Collaborative would like to acknowledge funding from the BJUI, the Urology Foundation, Ferring Pharmaceuticals Ltd, Rosetrees Trust and Action Bladder Cancer UK. Veeru Kasivisvanathan is an Academic Clinical Lecturer funded by the United Kingdom National Institute for Health Research (NIHR). The views expressed in this publication are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. PubMed Indexed Collaborative Authors: Matthew Coward, Selcuk Sarikaya, Jacqueline Emkes, Rachel Jury. Research Funding Department of Health National Institute for Health Research National Institute for Health Research Rosetrees Trust Ferring Pharmaceuticals Urology Foundation University of North CarolinaPeer reviewedPublisher PD

Diet and the human gut microbiome : an international review

CITATION: Wilson, A. S. et al. 2020. Diet and the Human Gut Microbiome: An International Review. Digestive diseases and sciences, 65(3):723–740. doi:10.1007/s10620-020-06112-wThe original publication is available at https://www.springer.com/journal/10620This review summarizes the key results of recently published studies on the effects of dietary change and nutritional intervention on the human microbiome from around the world, focusing on the USA, Canada, Europe, Asia, and Africa. It first explores mechanisms that might explain the ability of fiber-rich foods to suppress the incidence and mortality from westernized diseases, notably cancers of the colon, breast, liver, cardiovascular, infectious, and respiratory diseases, diabetes, and obesity (O'Keefe in Lancet Gastroenterol Hepatol 4(12):984-996, 2019; Am J Clin Nutr 110:265-266, 2019). It summarizes studies from Africa which suggest that disturbance of the colonic microbiome may exacerbate chronic malnutrition and growth failure in impoverished communities and highlights the importance of breast feeding. The American section discusses the role of the microbiome in the swelling population of patients with obesity and type 2 diabetes and examines the effects of race, ethnicity, geography, and climate on microbial diversity and metabolism. The studies from Europe and Asia extoll the benefits of whole foods and plant-based diets. The Asian studies examine the worrying changes from low-fat, high-carbohydrate diets to high-fat, low-carbohydrate ones and the increasing appearance of westernized diseases as in Africa and documents the ability of high-fiber traditional Chinese diets to reverse type 2 diabetes and control weight loss. In conclusion, most of the studies reviewed demonstrate clear changes in microbe abundances and in the production of fermentation products, such as short-chain fatty acids and phytochemicals following dietary change, but the significance of the microbiota changes to human health, with the possible exception of the stimulation of butyrogenic taxa by fiber-rich foods, is generally implied and not measured. Further studies are needed to determine how these changes in microbiota composition and metabolism can improve our health and be used to prevent and treat disease.https://pubmed.ncbi.nlm.nih.gov/32060812/Publishers versio