Guest Editorial: Social and human aspects of cyber-physical systems

open6siIn the vision of Industry 4.0, the new industrial revolution is a revolution of cyber-physical systems, of which the Internet of Things forms a key foundation that has a great impact on the way people live, and the way businesses are organised. Cyber-physical systems are often considered feedback systems that integrate computation, networking, and physical processes, and more recently with ‘human-in-the-loop’ as one of the key research topics. The advances in social computing have connected human-inthe-loop in cyber-social systems such as Facebook and Twitter, while their social-physical activities are supported by the cyberphysical systems on or near their bodies and in their interconnected environments. Cyber-physical systems become an integral part of social-cyber-physical systems (SCPS) that weave into the sociotechnical fabric of human society. These hybrid systems, exhibiting both continuous (in physical and social spaces) and discrete (in cyberspaces) dynamic behaviour, give rise to not only new opportunities but also new challenges in designing products and services where human and technical aspects are massively intertwined. This Special Issue aims to present state-of-the-art research attempts and results on the topic of SCPS.openopenHu J.; Liang R.-H.; Shih C.-S.; Catala A.; Marcenaro L.; Osawa H.Hu, J.; Liang, R. -H.; Shih, C. -S.; CATALA MALLOFRE, Andreu; Marcenaro, L.; Osawa, H

Histomorphometric analysis of inflammatory response and necrosis in re-implanted central incisor of rats treated with low-level laser therapy

Low-level laser therapy is a tool employed in the management of post-operative inflammation process and in the enhancement of reparative process. The aim of the study was to perform histological evaluation of dental and periodontal ligament of rats central upper-left incisor teeth re-implanted and irradiated with low-level laser (InGaAl, 685 nm, 50 J/cm2) 15, 30, and 60 days after re-implantation. Seventy-two male rats had the central upper left incisor removed and kept for 15 min on dry gauze before replantation. Laser was irradiated over the root surface and empty alveolus prior replantation and over surrounding mucosa after the re-implantation. After histological procedures, all slices were analyzed regarding external resorption area and histological aspects. We observed an increase of root resorption (p < 0.05) in the control group compared to the laser group at 15, 30, and 60 days. These results showed that the laser groups developed less root resorption areas than the control group in all experimental periods. Additionally, histological analysis revealed less inflammatory cells and necrotic areas in laser groups

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly

Q Fever During Pregnancy: An Emerging Cause of Prematurity and Abortion

Background: Although the pathogenic role of Coxiella burnetii infection during pregnancy is controversial, some cases of stillbirth and abortion occurring after an acute or chronic infection have been mentioned in the literature. Recently, Q fever has been advocated as a significant cause of morbidity and mortality in pregnanc