Evaluation des pratiques concernant les céphalées chroniques quotidiennes en médecine générale (étude menée auprès des médecins généralistes de Lille et Roubaix)

Les Céphalées Chroniques Quotidiennes (CCQ) touchent environ 2 millions d adultes en France et sont à l origine d un handicap important pour les patients auquel s ajoute un retentissement socio-économique non négligeable. Les médecins généralistes (MG) sont souvent en 1ère ligne dans la prise en charge de cette pathologie. Objectif : Evaluer les connaissances et la prise en charge des CCQ par les médecins généralistes du département du Nord. Méthodes : Enquête de pratiques professionnelles réalisée via un questionnaire dédié adressé par courrier avec enveloppe réponse aux 276 médecins généralistes de Lille et Roubaix. Analyse descriptive des résultats puis comparaison des données selon le sexe, l âge et le nombre d années d exercice via le logiciel de statistique SAS version 9.2. Résultats : Un taux de réponse de 39,8% a été obtenu (n=110). 26.36% des praticiens répondaient ne pas savoir ce que sont les CCQ. 73.75% ne connaissaient pas l existence des recommandations de l HAS. Des examens complémentaires systématiques étaient réalisés par près de la moitié des MG face au diagnostic de CCQ. Cependant la recherche des facteurs associés aux CCQ apparaissait acquise par les praticiens et l intérêt du sevrage en cas d abus médicamenteux était pris en compte par la majorité des MG (90%). Bien que l instauration d un traitement de fond n était conseillée que par 60% des généralistes. Discussion : Cette étude permet de mettre en évidence des connaissances incomplètes et des prises en charge variées des médecins généralistes concernant les céphalées chroniques quotidiennes (CCQ) malgré l existence de recommandations éditées en 2004 par la Haute Autorité de Santé. Conclusion : Accorder une place plus importante aux CCQ dans la formation théorique des médecins généralistes permettrait l amélioration du diagnostic et de la prise en charge des CCQ et limiterait également des dépenses de santé inutiles.LILLE2-BU Santé-Recherche (593502101) / SudocSudocFranceF

Economic Analysis of Summer Fallow Management to Reduce Take-All and N-Leaching in a Wheat Crop Rotation

This paper addresses the question of summer cover crop adoption by farmers in presence of a risk of yield loss due to take-all disease and climate variability. To analyse the public incentives needed to encourage farmers to adopt summer cover crops as a means of reducing N leaching, we combine outputs from an economic, an epidemiological and an agronomic model. The economic model is a simple model of choice under uncertainty. The farmer is assumed to choose among a range of summer fallow managements and input uses on the basis of the expected utility criterion (HARA assumption) in presence of both climate and take all risks. The epidemiological model proposed by Ennaïfar et al. (2007) is used to determine the impact of take all on yields and N-uptake. The crop-soil model (STICS) is used to\ud compute yield developments and N-leaching under various management options and climatic conditions. These models are calibrated to match the conditions prevailing in Grignon, located in the main wheatgrowing\ud area in France. Eight management systems are examined: 4 summer fallow managements: 'wheat volunteers' (WV), 'bare soil' (BS), 'early mustard' (EM), 'late mustard' (LM), and 2 input intensities. We show that the optimal systems are BS (WV) when the take-all risk is (not) taken into account by agents. We then compute the minimum payment to each system such that it emerges in the optimum. We thus derive the required amounts of transfer needed to trigger catch crop adoption. The results of the Monte Carlo sensitivity analysis show that the ranking of management systems is robust over a wide range of input parameters

Regulation of FATTY ACID ELONGATION1 expression in embryonic and vascular tissues of Brassica napus

International audienceThe expression of the FATTY ACID ELONGATION1 genes was characterised to provide insight into the regulation of very long chain fatty acid (VLCFA) biosynthesis in Brassica napus embryos. Each of the two rapeseed homoeologous genes (Bn-FAE1.1 and Bn-FAE1.2) encoding isozymes of 3-keto-acylCoA synthase, a subunit of the cytoplasmic acyl-CoA elongase complex that controls the production of elongated fatty acids, are expressed predominantly in developing seeds. The proximal regions of the Bn-FAE1.1 and Bn-FAE1.2 promoters possess strong sequence identity suggesting that transcriptional control of expression is mediated by this region which contains putative cis-elements characteristic of those found in the promoters of genes expressed in embryo and endosperm. Histochemical staining of rapeseed lines expressing Bn-FAE1.1 promoter:reporter gene fusions revealed a strong expression in the embryo cotyledon and axis throughout the maturation phase. Quantitative analyses revealed the region, −331 to −149, exerts a major control on cotyledon specific expression and the level of expression. A second region, −640 to −475, acts positively to enhance expression levels and extends expression of Bn-FAE1.1 into the axis and hypocotyl but also acts negatively to repress expression in the root meristem. The expression of the Bn-FAE1.1 gene was not restricted to the seed but was also detected in the vascular tissues of germinating seedlings and mature plants in the fascicular cambium tissue present in roots, stem and leaf petiole. We propose that Bn-FAE1.1 expression in vascular tissue may contribute VLCFA for barrier lipid synthesis and reflects the ancestral function of FAE1 encoded 3-keto-acylCoA synthase

The electronic structure of the triiodide ion from relativistic correlated calculations: a comparison of different methodologies.

International audienceThe triiodide ion I(3)(-) exhibits a complex photodissociation behavior, the dynamics of which are not yet fully understood. As a first step toward determining the full potential energy surfaces of this species for subsequent simulations of its dissociation processes, we investigate the performance of different electronic structure methods [time-dependent density functional theory, complete active space perturbation theory to second order (CASPT2), Fock-space coupled cluster and multireference configuration interaction] in describing the ground and excited states of the triiodide ion along the symmetrical dissociation path. All methods apart from CASPT2 include scalar relativity and spin-orbit coupling in the orbital optimization, providing useful benchmark data for the more common two-step approaches in which spin-orbit coupling is introduced in the configuration interaction. Time-dependent density functional theory with the statistical averaging of model orbital potential functional is off the mark for this system. Another choice of functional may improve performance with respect to vertical excitation energies and spectroscopic constants, but all functionals are likely to face instability problems away from the equilibrium region. The Fock-space coupled cluster method was shown to perform clearly best in regions not too far from equilibrium but is plagued by convergence problems toward the dissociation limit due to intruder states. CASPT2 shows good performance at significantly lower computational cost, but is quite sensitive to symmetry breaking. We furthermore observe spikes in the CASPT2 potential curves away from equilibrium, signaling intruder state problems that we were unable to curb through the use of level shifts. Multireference configuration interaction is, in principle, a viable option, but its computational cost in the present case prohibits use other than for benchmarking purposes

The electronic structure of the triiodide ion from relativistic correlated calculations: a comparison of different methodologies.

International audienceThe triiodide ion I(3)(-) exhibits a complex photodissociation behavior, the dynamics of which are not yet fully understood. As a first step toward determining the full potential energy surfaces of this species for subsequent simulations of its dissociation processes, we investigate the performance of different electronic structure methods [time-dependent density functional theory, complete active space perturbation theory to second order (CASPT2), Fock-space coupled cluster and multireference configuration interaction] in describing the ground and excited states of the triiodide ion along the symmetrical dissociation path. All methods apart from CASPT2 include scalar relativity and spin-orbit coupling in the orbital optimization, providing useful benchmark data for the more common two-step approaches in which spin-orbit coupling is introduced in the configuration interaction. Time-dependent density functional theory with the statistical averaging of model orbital potential functional is off the mark for this system. Another choice of functional may improve performance with respect to vertical excitation energies and spectroscopic constants, but all functionals are likely to face instability problems away from the equilibrium region. The Fock-space coupled cluster method was shown to perform clearly best in regions not too far from equilibrium but is plagued by convergence problems toward the dissociation limit due to intruder states. CASPT2 shows good performance at significantly lower computational cost, but is quite sensitive to symmetry breaking. We furthermore observe spikes in the CASPT2 potential curves away from equilibrium, signaling intruder state problems that we were unable to curb through the use of level shifts. Multireference configuration interaction is, in principle, a viable option, but its computational cost in the present case prohibits use other than for benchmarking purposes

Loops under Strategies ... Continued

While there are many approaches for automatically proving termination of term rewrite systems, up to now there exist only few techniques to disprove their termination automatically. Almost all of these techniques try to find loops, where the existence of a loop implies non-termination of the rewrite system. However, most programming languages use specific evaluation strategies, whereas loop detection techniques usually do not take strategies into account. So even if a rewrite system has a loop, it may still be terminating under certain strategies. Therefore, our goal is to develop decision procedures which can determine whether a given loop is also a loop under the respective evaluation strategy. In earlier work, such procedures were presented for the strategies of innermost, outermost, and context-sensitive evaluation. In the current paper, we build upon this work and develop such decision procedures for important strategies like leftmost-innermost, leftmost-outermost, (max-)parallel-innermost, (max-)parallel-outermost, and forbidden patterns (which generalize innermost, outermost, and context-sensitive strategies). In this way, we obtain the first approach to disprove termination under these strategies automatically.Comment: In Proceedings IWS 2010, arXiv:1012.533

Selecting Better Samples from Pre-trained LLMs: A Case Study on Question Generation

Large Language Models (LLMs) have in recent years demonstrated impressive prowess in natural language generation. A common practice to improve generation diversity is to sample multiple outputs from the model. However, there lacks a simple and robust way of selecting the best output from these stochastic samples. As a case study framed in the context of question generation, we propose two prompt-based approaches to selecting high-quality questions from a set of LLM-generated candidates. Our method works under the constraints of 1) a black-box (non-modifiable) question generation model and 2) lack of access to human-annotated references -- both of which are realistic limitations for real-world deployment of LLMs. With automatic as well as human evaluations, we empirically demonstrate that our approach can effectively select questions of higher qualities than greedy generation

Tracking beats and microtiming in Afro-Latin American music using conditional random fields and deep learning

Trabajo presentado en ISMIR 2019 : 20th Conference of the International Society for Music Information Retrieval, Delft, Netherlands, 4-8 nov, 2019PostprintEvents in music frequently exhibit small-scale temporal deviations (microtiming), with respect to the underlying regular metrical grid. In some cases, as in music from the Afro-Latin American tradition, such deviations appear systematically, disclosing their structural importance in rhythmic and stylistic configuration. In this work we explore the idea of automatically and jointly tracking beats and microtiming in timekeeper instruments of Afro-Latin American music, in particular Brazilian samba and Uruguayan candombe. To that end, we propose a language model based on conditional random fields that integrates beat and onset likelihoods as observations. We derive those activations using deep neural networks and evaluate its performance on manually annotated data using a scheme adapted to this task. We assess our approach in controlled conditions suitable for these timekeeper instruments, and study the microtiming profiles’ dependency on genre and performer, illustrating promising aspects of this technique towards a more comprehensive understanding of these music traditions

Readability of the Written Study Information in Pediatric Research in France

BACKGROUND: The aim was to evaluate the readability of research information leaflets (RIL) for minors asked to participate in biomedical research studies and to assess the factors influencing this readability. METHODS AND FINDINGS: All the pediatric protocols from three French pediatric clinical research units were included (N = 104). Three criteria were used to evaluate readability: length of the text, Flesch's readability score and presence of illustrations. We compared the readability of RIL to texts specifically written for children (school textbooks, school exams or extracts from literary works). We assessed the effect of protocol characteristics on readability. The RIL had a median length of 608 words [350 words, 25(th) percentile; 1005 words, 75(th) percentile], corresponding to two pages. The readability of the RIL, with a median Flesch score of 40 [30; 47], was much poorer than that of pediatric reference texts, with a Flesch score of 67 [60; 73]. A small proportion of RIL (13/91; 14%) were illustrated. The RIL were longer (p<0.001), more readable (p<0.001) and more likely to be illustrated (p<0.009) for industrial than for institutional sponsors. CONCLUSION: Researchers should routinely compute the reading ease of study information sheets and make greater efforts to improve the readability of written documents for potential participants