205 research outputs found
The CLIC Programme: Towards a Staged e+e- Linear Collider Exploring the Terascale : CLIC Conceptual Design Report
This report describes the exploration of fundamental questions in particle
physics at the energy frontier with a future TeV-scale e+e- linear collider
based on the Compact Linear Collider (CLIC) two-beam acceleration technology. A
high-luminosity high-energy e+e- collider allows for the exploration of
Standard Model physics, such as precise measurements of the Higgs, top and
gauge sectors, as well as for a multitude of searches for New Physics, either
through direct discovery or indirectly, via high-precision observables. Given
the current state of knowledge, following the observation of a 125 GeV
Higgs-like particle at the LHC, and pending further LHC results at 8 TeV and 14
TeV, a linear e+e- collider built and operated in centre-of-mass energy stages
from a few-hundred GeV up to a few TeV will be an ideal physics exploration
tool, complementing the LHC. In this document, an overview of the physics
potential of CLIC is given. Two example scenarios are presented for a CLIC
accelerator built in three main stages of 500 GeV, 1.4 (1.5) TeV, and 3 TeV,
together with operating schemes that will make full use of the machine capacity
to explore the physics. The accelerator design, construction, and performance
are presented, as well as the layout and performance of the experiments. The
proposed staging example is accompanied by cost estimates of the accelerator
and detectors and by estimates of operating parameters, such as power
consumption. The resulting physics potential and measurement precisions are
illustrated through detector simulations under realistic beam conditions.Comment: 84 pages, published as CERN Yellow Report
https://cdsweb.cern.ch/record/147522
The bovine foot skin microbiota is associated with host genotype and the development of infectious digital dermatitis lesions
The bovine foot skin microbiota is associated with host genotype and the development of infectious digital dermatitis lesions
The bovine foot skin microbiota is associated with host genotype and the development of infectious digital dermatitis lesions
Abstract
Background
Bovine Digital Dermatitis (BDD) is a prevalent infectious disease, causing painful foot skin lesions and lameness in cattle. We describe herein the bovine foot skin microbiota and its associations with BDD using 16S rRNA gene amplicon and shotgun metagenomic sequencing on samples from 259 dairy cows from three UK dairy farms.
Results
We show evidence of dysbiosis, and differences in taxonomy and functional profiles in the bovine foot skin microbiome of clinically healthy animals that subsequently develop BDD lesions, compared to those that do not. Our results suggest that taxonomical and functional differences together with alterations in ecological interactions between bacteria in the normal foot skin microbiome may predispose an animal to develop BDD lesions. Using genome-wide association and regional heritability mapping approaches, we provide first evidence for interactions between host genotype and certain members of the foot skin microbiota. We show the existence of significant genetic variation in the relative abundance of Treponema spp. and Peptoclostridium spp. and identify regions in the bovine genome that explain a significant proportion of this variation.
Conclusions
Collectively this work shows early changes in taxonomic and functional profiles of the bovine foot-skin microbiota in clinically healthy animals which are associated with subsequent development of BDD and could be relevant to prevention of disease. The description of host genetic control of members of the foot skin microbiota, combined with the association of the latter with BDD development offer new insights into a complex relationship that can be exploited in selective breeding programmes.
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Search for Doubly-Charged Higgs Boson Production at HERA
A search for the single production of doubly-charged Higgs bosons H^{\pm \pm}
in ep collisions is presented. The signal is searched for via the Higgs decays
into a high mass pair of same charge leptons, one of them being an electron.
The analysis uses up to 118 pb^{-1} of ep data collected by the H1 experiment
at HERA. No evidence for doubly-charged Higgs production is observed and mass
dependent upper limits are derived on the Yukawa couplings h_{el} of the Higgs
boson to an electron-lepton pair. Assuming that the doubly-charged Higgs only
decays into an electron and a muon via a coupling of electromagnetic strength
h_{e \mu} = \sqrt{4 \pi \alpha_{em}} = 0.3, a lower limit of 141 GeV on the
H^{\pm\pm} mass is obtained at the 95% confidence level. For a doubly-charged
Higgs decaying only into an electron and a tau and a coupling h_{e\tau} = 0.3,
masses below 112 GeV are ruled out.Comment: 15 pages, 3 figures, 1 tabl
Pion and proton showers in the CALICE scintillator-steel analogue hadron calorimeter
Showers produced by positive hadrons in the highly granular CALICE
scintillator-steel analogue hadron calorimeter were studied. The experimental
data were collected at CERN and FNAL for single particles with initial momenta
from 10 to 80 GeV/c. The calorimeter response and resolution and spatial
characteristics of shower development for proton- and pion-induced showers for
test beam data and simulations using Geant4 version 9.6 are compared.Comment: 26 pages, 16 figures, JINST style, changes in the author list, typos
corrected, new section added, figures regrouped. Accepted for publication in
JINS
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