"Il controllo di gestione nel Supply Chain Management. Analisi degli scostamenti e degli indicatori non tradizionali di performance nelle PMI: il caso Galleno Plastica S.r.l."

A causa della crisi globale del 2009, le aziende italiane sono state costrette ad ottenere informazioni utili alla loro sopravvivenza, potenziando il controllo di gestione, e congiuntamente razionalizzando le proprie organizzazioni. Questa tesi si pone nell'ottica di studiare come il controllo di gestione, attraverso anche l'analisi degli scostamenti e degli indicatori di performance tradizionali e non, impatti sull'applicazione del supply chain management, in un caso reale di PMI italiana

Brain-computer interface for robot control with eye artifacts for assistive applications

Human-robot interaction is a rapidly developing field and robots have been taking more active roles in our daily lives. Patient care is one of the fields in which robots are becoming more present, especially for people with disabilities. People with neurodegenerative disorders might not consciously or voluntarily produce movements other than those involving the eyes or eyelids. In this context, Brain-Computer Interface (BCI) systems present an alternative way to communicate or interact with the external world. In order to improve the lives of people with disabilities, this paper presents a novel BCI to control an assistive robot with user's eye artifacts. In this study, eye artifacts that contaminate the electroencephalogram (EEG) signals are considered a valuable source of information thanks to their high signal-to-noise ratio and intentional generation. The proposed methodology detects eye artifacts from EEG signals through characteristic shapes that occur during the events. The lateral movements are distinguished by their ordered peak and valley formation and the opposite phase of the signals measured at F7 and F8 channels. This work, as far as the authors' knowledge, is the first method that used this behavior to detect lateral eye movements. For the blinks detection, a double-thresholding method is proposed by the authors to catch both weak blinks as well as regular ones, differentiating itself from the other algorithms in the literature that normally use only one threshold. Real-time detected events with their virtual time stamps are fed into a second algorithm, to further distinguish between double and quadruple blinks from single blinks occurrence frequency. After testing the algorithm offline and in realtime, the algorithm is implemented on the device. The created BCI was used to control an assistive robot through a graphical user interface. The validation experiments including 5 participants prove that the developed BCI is able to control the robot

Ideal Quantum Gases in D-dimensional Space and Power-law Potentials

We investigate ideal quantum gases in D-dimensional space and confined in a generic external potential by using the semiclassical approximation. In particular, we derive density of states, density profiles and critical temperatures for Fermions and Bosons trapped in isotropic power-law potentials. Form such results, one can easily obtain those of quantum gases in a rigid box and in a harmonic trap. Finally, we show that the Bose-Einstein condensation can set up in a confining power-law potential if and only if ${D/2}+{D/n}>1$, where $D$ is the space dimension and $n$ is the power-law exponent.Comment: 18 pages, Latex, to be published in Journal of Mathematical Physic

The use (and misuse) of phylogenetic trees in comparative behavioral analyses

Abstract Phylogenetic comparative methods play a critical role in our understanding of the adaptive origin of primate behaviors. To incorporate evolutionary history directly into comparative behavioral research, behavioral ecologists rely on strong, wellresolved phylogenetic trees. Phylogenies provide the framework on which behaviors can be compared and homologies can be distinguished from similarities due to convergent or parallel evolution. Phylogenetic reconstructions are also of critical importance when inferring the ancestral state of behavioral patterns and when suggesting the evolutionary changes that behavior has undergone. Improvements in genome sequencing technologies have increased the amount of data available to researchers. Recently, several primate phylogenetic studies have used multiple loci to produce robust phylogenetic trees that include hundreds of primate species. These trees are now commonly used in comparative analyses and there is a perception that we have a complete picture of the primate tree. But how confident can we be in those phylogenies? And how reliable are comparative analyses based on such trees? Herein, we argue that even recent molecular phylogenies should be treated cautiously because they rely on many assumptions and have many shortcomings. Most phylogenetic studies do not model gene tree diversity and can produce misleading results, such as strong support for an incorrect species tree, especially in the case of rapid and recent radiations. We discuss implications that incorrect phylogenies can have for reconstructing the evolution of primate behaviors and we urge primatologists to be aware of the current limitations of phylogenetic reconstructions when applying phylogenetic comparative methods

Unfolding the interaction between microplastics and (trace) elements in water: A critical review

Plastic and microplastic pollution is an environmental and societal concern. The interaction of plastic with organic chemicals in the environment has attracted scientific interest. New evidences have highlighted an unexpectedly high affinity of environmental plastics also for metal ions. The degree and typology of plastic ageing (including from mechanical, UV and biological degradations) appear as a pivotal factor determining such an interaction. These earlier evidences recently opened a new research avenue in the plastic pollution area. This review is the first to organize and critically discuss knowledge developed so far. Results from field and laboratory studies of metal accumulation on plastic are presented and the environmental factors most likely to control such an interaction are discussed. On the light of this knowledge, a generalist conceptual model useful for building hypotheses on the mechanisms at stake and directing future studies was elaborated and presented here. Furthermore, all available data on the thermodynamics of the plastic-metal interaction obtained from laboratory experiments are inventoried and discussed here, highlighting methodological and technical challenges that can potentially affect cross-comparability of data and their relevance for environmental settings. Finally, insights and recommendations on experimental approaches and analytical techniques that can help overtaking current limitations and knowledge gaps are proposed

Investigating the mechanism of action of DNA-loaded PEGylated lipid nanoparticles

PEGylated lipid nanoparticles (LNPs) are commonly used to deliver bioactive molecules, but the role of PEGylation in DNA-loaded LNP interactions at the cellular and subcellular levels remains poorly understood. In this study, we investigated the mechanism of action of DNA-loaded PEGylated LNPs using gene reporter technologies, dynamic light scattering (DLS), synchrotron small angle X-ray scattering (SAXS), and fluorescence confocal microscopy (FCS). We found that PEG has no significant impact on the size or nanostructure of DNA LNPs but reduces their zeta potential and interaction with anionic cell membranes. PEGylation increases the structural stability of LNPs and results in lower DNA unloading. FCS experiments revealed that PEGylated LNPs are internalized intact inside cells and largely shuttled to lysosomes, while unPEGylated LNPs undergo massive destabilization on the plasma membrane. These findings can inform the design, optimization, and validation of DNA-loaded LNPs for gene delivery and vaccine development

Physicochemical and biological ageing processes of (micro)plastics in the environment: a multi-tiered study on polyethylene

Pollution by plastic and microplastic impacts the environment globally. Knowledge on the ageing mechanisms of plastics in natural settings is needed to understand their environmental fate and their reactivity in the ecosystems. Accordingly, the study of ageing processes is gaining focus in the context of the environmental sciences. However, laboratory-based experimental research has typically assessed individual ageing processes, limiting environmental applicability. In this study, we propose a multi-tiered approach to study the environmental ageing of polyethylene plastic fragments focusing on the combined assessment of physical and biological processes in sequence. The ageing protocol included ultraviolet irradiation in air and in a range of water solutions, followed by a biofouling test. Changes in surface characteristics were assessed by Fourier transform infrared spectroscopy, scanning electron microscopy, and water contact angle. UV radiation both in air and water caused a significant increase in the density of oxidized groups (i.e., hydroxyl and carbonyl) on the plastic surface, whereby water solution chemistry influenced the process both by modulating surface oxidation and morphology. Biofouling, too, was a strong determinant of surface alterations, regardless of the prior irradiation treatments. All biofouled samples present (i) specific infrared bands of new surface functional groups (e.g., amides and polysaccharides), (ii) a further increase in hydroxyl and carbonyl groups, (iii) the diffuse presence of algal biofilm on the plastic surface, and (iv) a significant decrease in surface hydrophobicity. This suggests that biological-driven alterations are not affected by the level of physicochemical ageing and may represent, in real settings, the main driver of alteration of both weathered and pristine plastics. This work highlights the potentially pivotal role of biofouling as the main process of plastic ageing, providing useful technical insights for future experimental works. These results also confirm that a multi-tiered laboratory approach permits a realistic simulation of plastic environmental ageing in controlled conditions