13 research outputs found
Incidence of Sarcoma Histotypes and Molecular Subtypes in a Prospective Epidemiological Study with Central Pathology Review and Molecular Testing
International audienceBACKGROUND: The exact overall incidence of sarcoma and sarcoma subtypes is not known. The objective of the present population-based study was to determine this incidence in a European region (Rhone-Alpes) of six million inhabitants, based on a central pathological review of the cases. METHODOLOGY/PRINCIPAL FINDINGS: From March 2005 to February 2007, pathology reports and tumor blocks were prospectively collected from the 158 pathologists of the Rhone-Alpes region. All diagnosed or suspected cases of sarcoma were collected, reviewed centrally, examined for molecular alterations and classified according to the 2002 World Health Organization classification. Of the 1287 patients screened during the study period, 748 met the criteria for inclusion in the study. The overall crude and world age-standardized incidence rates were respectively 6.2 and 4.8 per 100,000/year. Incidence rates for soft tissue, visceral and bone sarcomas were respectively 3.6, 2.0 and 0.6 per 100,000. The most frequent histological subtypes were gastrointestinal stromal tumor (18%; 1.1/100,000), unclassified sarcoma (16%; 1/100,000), liposarcoma (15%; 0.9/100,000) and leiomyosarcoma (11%; 0.7/100,000). CONCLUSIONS/SIGNIFICANCE: The observed incidence of sarcomas was higher than expected. This study is the first detailed investigation of the crude incidence of histological and molecular subtypes of sarcomas
Intérêt des anticorps monoclonaux anti-cytokératines CK5/6 et 34 E12 dans le diagnostic des lésions épitthéliales proliférantes non invasives du sein
TOULOUSE3-BU Santé-Centrale (315552105) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF
Description of GIST stratification risk.
<p>NIH, National Institutes of Health ; AFIP, Armed Forces Institute of Pathology.</p>1<p>Grade was not evaluated due to limited material or too undifferentiated tumor.</p
Rare histological types of sarcoma.
1<p>MPNST, malignant peripheral nerve sheath tumor.</p>2<p>PEComa, neoplasm with perivascular epithelioid cell differentiation.</p
Distribution of molecular subtypes for sarcoma with specific gene abnormality (N = 362).
<p>GIST, gastrointestinal stromal tumors; PNET, primitive neuroectodermal tumor.</p>1<p>CIR: Crude incidence rate/100,000/year.</p>2<p>Molecular biology analysis not performed in France.</p>3<p>Detection of rearrangement of ALK gene.</p>4<p>Possible fusion transcript: TLS-CHOP; EWS-CHOP.</p>5<p>Possible fusion transcript: EWS-FLI1; EWS-ERG; EWS-FEV; EWS-EIAF; EWS-ETV1.</p>6<p>Possible fusion transcript: PAX3-FKHR; PAX7-FKHR.</p
Crude incidence of histological subtypes.
<p>GIST, gastrointestinal stromal tumor; PNET, primitive neuroectodermal tumor.</p>1<p>Crude incidence rate/100,000/year.</p>2<p>Unclassified sarcomas were divided in subtypes according to morphological features based on experts' advice.</p
Age-specific incidence rates (per 100,000).
<p>(<b>A</b>) Age-specific rates by sarcoma type. (<b>B</b>) Age-specific rates within bone sarcomas, for the 3 most important histotypes. (<b>C</b>) Age-specific rates for liposarcoma subtypes.</p
Description of tumor grade.
1<p>Grade was not evaluated due to limited material or too undifferentiated tumor.</p
The French ADICAP coding system (http://www.adicap.asso.fr/).
<p>The French ADICAP coding system (<a href="http://www.adicap.asso.fr/" target="_blank">http://www.adicap.asso.fr/</a>).</p
General characteristics of sarcoma patients in the Rhone-Alpes region, France, 2005–2006.
1<p>According to pathology report n = 535 (71%), to imaging n = 133 (18%) or to physical examination n = 9 (1%).</p>2<p>Above or under superficial fascia.</p