Compton processes in the bright AGN MCG+8-11-11

We present preliminary results on the hard X-ray emission properties of the Seyfert 1.5 galaxy MCG+8-11-11 as observed by INTEGRAL and SWIFT. All the INTEGRAL IBIS/ISGRI data available up to October 2009 have been analyzed together with two SWIFT/XRT snapshot observations performed in August and October 2009, quasi-simultaneously to INTEGRAL pointed observations of MCG+8-11-11. No correlation is observed between the hard X-ray flux and the spectral slope, while the position of the high-energy cut-off is found to have varied during the INTEGRAL observations. This points to a change in the temperature of the Comptonising medium from a minimum value of kT = 30-50 keV to values larger than 100-150 keV. There is no significant detection of Compton reflection, with a 3 sigma upper limit of R < 0.2, and no line has been detected at 112 keV, as previously claimed from HEAT observations (112 keV flux F < 2.4e-4 ph/cm^2/s). The variability behaviour of MCG+8-11-11 is found to be similar to that shown by IC 4329A, with different temperatures of the electron plasma for similar flux levels of the source, while other bright Seyfert galaxies present different variability patterns at hard X-rays, with spectral changes correlated to flux variations (e.g. NGC 4151).Comment: 6 pages, 4 figures. Accepted for publication on PoS (contribution PoS(INTEGRAL 2010)077), proceedings of the 8th INTEGRAL Workshop "The Restless Gamma-ray Universe" (September 2010, Dublin, Ireland

Composition of the nuclear periphery from antiproton absorption

Thirteen targets with mass numbers from 58 to 238 were irradiated with the antiproton beam from the Low Energy Antiproton Ring facility at CERN leading to the formation of antiprotonic atoms of these heavy elements. The antiproton capture at the end of an atomic cascade results in the production of more or less excited residual nuclei. The targets were selected with the criterion that both reaction products with one nucleon less than the proton and neutron number of the target be radioactive. The yield of these radioactive products after stopped-antiproton annihilation was determined using gamma-ray spectroscopy techniques. This yield is related to the proton and neutron density in the target nucleus at a radial distance corresponding to the antiproton annihilation site. The experimental data clearly indicate the existence of a neutron-rich nuclear periphery, a "neutron halo", strongly correlated with the target neutron separation energy Bn and observed for targets with Bn < 10 MeV. For two-target nuclei 106Cd and 144Sm, with larger neutron binding energies, a proton-rich nuclear periphery was observed. Most of the experimental data are in reasonable agreement with calculations based on current antiproton-nucleus and pion-nucleus interaction potentials and on nuclear densities deduced with the help of the Hartree-Fock-Bogoliubov approach. This approach was, however, unable to account for the 106Cd and 144Sm results.Comment: Latex (RevTeX,aps style), 13 pages + 12 Postscript figure

Long-term variability of AGN at hard X-rays

Variability at all observed wavelengths is a distinctive property of AGN. Hard X-rays provide us with a view of the innermost regions of AGN, mostly unbiased by absorption along the line of sight. Swift/BAT offers the unique opportunity to follow, on time scales of days to years and with a regular sampling, the 14-195 keV emission of the largest AGN sample available up to date for this kind of investigation. We study the amplitude of the variations, and their dependence on sub-class and on energy, for a sample of 110 radio quiet and radio loud AGN selected from the BAT 58-month survey. About 80% of the AGN in the sample are found to exhibit significant variability on months to years time scales, radio loud sources being the most variable. The amplitude of the variations and their energy dependence are incompatible with variability being driven at hard X-rays by changes of the absorption column density. In general, the variations in the 14-24 and 35-100 keV bands are well correlated, suggesting a common origin of the variability across the BAT energy band. However, radio quiet AGN display on average 10% larger variations at 14-24 keV than at 35-100 keV and a softer-when-brighter behavior for most of the Seyfert galaxies with detectable spectral variability on month time scale. In addition, sources with harder spectra are found to be more variable than softer ones. These properties are generally consistent with a variable power law continuum, in flux and shape, pivoting at energies >~ 50 keV, to which a constant reflection component is superposed. When the same time scales are considered, the timing properties of AGN at hard X-rays are comparable to those at lower energies, with at least some of the differences possibly ascribable to components contributing differently in the two energy domains (e.g., reflection, absorption).Comment: 17 pages, 11 figures, accepted for publication in A&

INTEGRAL observations of V0332+53 in outburst

We present the analysis of a 100ksec Integral(3-100kev) observation of the transient X-ray pulsar V0332+53 inoutburst. The source is pulsating at P=4.3751+/-0.0002s with a clear double pulse from 6 kev to 60 kev. The average flux was ~550mCrab between 20 kev and 60 kev. We modeled the broad band continuum from 5 kev to 100 kev with a power-law modified by an exponential cut off. We observe three cyclotron lines: the fundamental line at 24.9+/-0.1 kev, the first harmonic at 50.5+/-0.1 kev as well as the second harmonic at71.7+/-0.8 kev, thus confirming the discovery of the harmonic lines by Coburn et al. (2005) in RXTE data.Comment: 4 pages, 3 figures. Accepted for publication in A&A Letter

Gold fragmentation induced by stopped antiprotons

A natural gold target was irradiated with the antiproton beam from the Low Energy Antiproton Ring at CERN. Antiprotons of 200 MeV/c momentum were stopped in a thick target, products of their annihilations on Au nuclei were detected using the off-line gamma-ray spectroscopy method. In total, yields for 114 residual nuclei were determined, providing a data set to deduce the complete mass and charge distribution of all products with A > 20 from a fitting procedure. The contribution of evaporation and fission decay modes to the total reaction cross section as well as the mean mass loss were estimated. The fission probability for Au absorbing antiprotons at rest was determined to be equal to (3.8+-0.5)%, in good agreement with an estimation derived using other techniques. The mass-charge yield distribution was compared with the results obtained for proton and pion induced gold fragmentation. On the average, the energy released in pbar annihilation is similar to that introduced by ~ 1 GeV protons. However, compared to proton bombardment products, the yield distribution of antiproton absorption residues in the N-Z plane is clearly distinct. The data for antiprotons exhibit also a substantial influence of odd-even and shell effects.Comment: 14 pages, 9 figures, Revtex 4, to be published in Physical Review

A comprehensive analysis of the hard X-ray spectra of bright Seyfert galaxies

Hard X-ray spectra of 28 bright Seyfert galaxies observed with INTEGRAL were analyzed together with the X-ray spectra from XMM-Newton, Suzaku and RXTE. These broad-band data were fitted with a model assuming a thermal Comptonization as a primary continuum component. We tested several model options through a fitting of the Comptonized continuum accompanied by a complex absorption and a Compton reflection. Both the large data set used and the model space explored allowed us to accurately determine a mean temperature kTe of the electron plasma, the Compton parameter y and the Compton reflection strength R for the majority of objects in the sample. Our main finding is that a vast majority of the sample (20 objects) is characterized by kTe < 100 keV, and only for two objects we found kTe > 200 keV. The median kTe for entire sample is 48(-14,+57) keV. The distribution of the y parameter is bimodal, with a broad component centered at ~0.8 and a narrow peak at ~1.1. A complex, dual absorber model improved the fit for all data sets, compared to a simple absorption model, reducing the fitted strength of Compton reflection by a factor of about 2. Modest reflection (median R ~0.32) together with a high ratio of Comptonized to seed photon fluxes point towards a geometry with a compact hard X-ray emitting region well separated from the accretion disc. Our results imply that the template Seyferts spectra used in AGN population synthesis models should be revised.Comment: 26 pages, 12 figures, accepted for publication in MNRA

Analysis of Germline Variants in CDH1, IGFBP3, MMP1, MMP3, STK15 and VEGF in Familial and Sporadic Renal Cell Carcinoma

BACKGROUND:The investigation of rare familial forms of kidney cancer has provided important insights into the biology of sporadic renal cell carcinoma (RCC). In particular, the identification of the von Hippel Lindau (VHL) familial cancer syndrome gene (VHL) provided the basis for the discovery that VHL is somatically inactivated in most sporadic clear cell RCC. Many cases of familial RCC do not have mutations in known RCC susceptibility genes and there is evidence that genetic modifiers may influence the risk of RCC in VHL disease patients. Hence we hypothesised that low-penetrance functional genetic variants in pathways related to the VHL protein (pVHL) function might (a) modify the phenotypic expression of VHL disease and/or (b) predispose to sporadic RCC. METHODOLOGY/PRINCIPAL FINDINGS:We tested this hypothesis for functional polymorphisms in CDH1 (rs16260), IGFBP3 (rs2854744), MMP1 (rs1799750), MMP3 (rs679620), STK15 (rs2273535) and VEGF (rs1570360). We observed that variants of MMP1 and MMP3 were significant modifiers of RCC risk (and risks of retinal angioma and cerebellar haemangioblastoma) in VHL disease patients. In addition, higher frequencies of the MMP1 rs1799750 2G allele (p = 0.017, OR 1.49, 95%CI 1.06-2.08) and the MMP1/MMP3 rs1799750/rs679620 2G/G haplotype (OR 1.45, 95%CI 1.01-2.10) were detected in sporadic RCC patients than in controls (n = 295). CONCLUSIONS/SIGNIFICANCE:These findings (a) represent the first example of genetic modifiers of RCC risk in VHL disease, (b) replicate a previous report of an association between MMP1/MMP3 variants and sporadic RCC and (c) further implicate MMP1/MMP3-related pathways in the pathogenesis of familial and sporadic RCC

The Second INTEGRAL AGN Catalogue

The INTEGRAL mission provides a large data set for studying the hard X-ray properties of AGN and allows testing of the unified scheme for AGN. We present analysis of INTEGRAL IBIS/ISGRI, JEM-X, and OMC data for 199 AGN supposedly detected by INTEGRAL above 20 keV. The data analysed here allow a significant spectral extraction on 148 objects and an optical variability study of 57 AGN. The slopes of the hard X-ray spectra of Seyfert 1 and Seyfert~2 galaxies are found to be consistent within the uncertainties, whereas higher cut-off energies and lower luminosities are measured for the more absorbed / type 2 AGN. The intermediate Seyfert 1.5 objects exhibit hard X-ray spectra consistent with those of Seyfert 1. When applying a Compton reflection model, the underlying continua appear the same in Seyfert 1 and 2 with photon index 2, and the reflection strength is about R = 1, when assuming different inclination angles. A significant correlation is found between the hard X-ray and optical luminosity and the mass of the central black hole in the sense that the more luminous objects appear to be more massive. There is also a general trend toward the absorbed sources and type 2 AGN having lower Eddington ratios. The black holemass appears to form a fundamental plane together with the optical and X-ray luminosity of the form Lv being proportional to Lx^0.6 M^0.2, similar to that found between radio luminosity Lr, Lx, and M. The unified model for Seyfert galaxies seems to hold, showing in hard X-rays that the central engine is the same in Seyfert 1 and 2, but seen under different inclination angles and absorption. (Abridged)Comment: 26 pages, 16 figures, accepted for publication in A&A. Corrections by language editor included in version