A Crucial Role of IL-17 and IFN-γ during Acute Rejection of Peripheral Nerve Xenotransplantation in Mice

Nerve injuries causing segmental loss require nerve grafting. However, autografts and allografts have limitations for clinical use. Peripheral nerve xenotransplantation has become an area of great interest in clinical surgery research as an alternative graft strategy. However, xenotransplant rejection is severe with cellular immunity, and Th1 cells play an important role in the process. To better understand the process of rejection, we used peripheral nerve xenografts from rats to mice and found that mononuclear cells expressing IFN-γ and IL-17 infiltrated around the grafts, and IFN-γ and IL-17 producing CD4+ and CD8+ T cells increased during the process of acute rejection. The changes of IL-4 level had no significant difference between xenotransplanted group and sham control group. The rejection of xenograft was significantly prevented after the treatment of IL-17 and IFN-γ neutralizing antibodies. These data suggest that Th17 cells contribute to the acute rejection process of peripheral nerve xenotransplant in addition to Th1 cells

Dual behavior of caustic optical beams facing obstacles

A full propagation analysis on both fold-type and cusp-type caustic optical beams under various setups of obstructions is theoretically and experimentally performed. It is demonstrated that the self-healing property of caustic optical beams that include the famous Airy beam is a quite relative property. In fact, fold-type and cusp-type beams cannot only behave as self-healing beams by blocking the main intensity peak, but also behave as self-breaking ones in a nonintuitive manner: by blocking a lateral side of the beam without touching the central intensity peak. The regeneration and rupture processes of caustic beams follow a nonlocal propagation dynamic unlike the other conventional beams. Moreover, deep differences between fold and cusp caustic beams are pointed out once facing certain obstructions. The cusp-caustic beam can be broken down by the obstacle placed in a dark zone outside the caustic region, while the fold-type one remains unaltered. This beam rupture confirms the key role of a hidden propagating field in the shadow region for cusp beams that coexist with the evanescent one. The obtained results cast down the established idea that the Airy beam is a robust self-healing beam since any caustic beam can behave in a dual manner depending on the obstruction location. These facts open up different perspectives for the applications in which the self-healing properties of the beam are relevant

Dual behavior of caustic optical beams facing obstacles

A full propagation analysis on both fold-type and cusp-type caustic optical beams under various setups of obstructions is theoretically and experimentally performed. It is demonstrated that the self-healing property of caustic optical beams that include the famous Airy beam is a quite relative property. In fact, fold-type and cusp-type beams cannot only behave as self-healing beams by blocking the main intensity peak, but also behave as self-breaking ones in a nonintuitive manner: by blocking a lateral side of the beam without touching the central intensity peak. The regeneration and rupture processes of caustic beams follow a nonlocal propagation dynamic unlike the other conventional beams. Moreover, deep differences between fold and cusp caustic beams are pointed out once facing certain obstructions. The cusp-caustic beam can be broken down by the obstacle placed in a dark zone outside the caustic region, while the fold-type one remains unaltered. This beam rupture confirms the key role of a hidden propagating field in the shadow region for cusp beams that coexist with the evanescent one. The obtained results cast down the established idea that the Airy beam is a robust self-healing beam since any caustic beam can behave in a dual manner depending on the obstruction location. These facts open up different perspectives for the applications in which the self-healing properties of the beam are relevant.Centro de Investigaciones ÓpticasFacultad de Ciencias Exacta

Dual behavior of caustic optical beams facing obstacles

A full propagation analysis on both fold-type and cusp-type caustic optical beams under various setups of obstructions is theoretically and experimentally performed. It is demonstrated that the self-healing property of caustic optical beams that include the famous Airy beam is a quite relative property. In fact, fold-type and cusp-type beams cannot only behave as self-healing beams by blocking the main intensity peak, but also behave as self-breaking ones in a nonintuitive manner: by blocking a lateral side of the beam without touching the central intensity peak. The regeneration and rupture processes of caustic beams follow a nonlocal propagation dynamic unlike the other conventional beams. Moreover, deep differences between fold and cusp caustic beams are pointed out once facing certain obstructions. The cusp-caustic beam can be broken down by the obstacle placed in a dark zone outside the caustic region, while the fold-type one remains unaltered. This beam rupture confirms the key role of a hidden propagating field in the shadow region for cusp beams that coexist with the evanescent one. The obtained results cast down the established idea that the Airy beam is a robust self-healing beam since any caustic beam can behave in a dual manner depending on the obstruction location. These facts open up different perspectives for the applications in which the self-healing properties of the beam are relevant.Centro de Investigaciones ÓpticasFacultad de Ciencias Exacta

catena-Poly[[bis­(pyridine-κN)nickel(II)]-μ-oxalato-κ4 O 1,O 2:O 1′,O 2′]

The title compound, [Ni(C2O4)(C5H5N)2]n, was synthesized under hydro­(solvo)thermal conditions. The NiII atom, lying on a twofold rotation axis, has an octa­hedral coordination geometry involving two N atoms from two pyridine ligands and four O atoms from two oxalate ligands. The Ni atoms are connected by the tetra­dentate bridging oxalate ligands into a one-dimensional zigzag chain

Design and Application of Exclusive Service App for Rural Elderly

With the further advancement of rural development and the rapid development of mobile Internet, rural service apps have gradually become an important means of promoting rural economic development and improving farmers’ production and living standards. At present, a number of service-type apps with wide applications in the field of rural services have emerged, such as “Planting Master”, “Farming Network”, “Rural Taobao”, etc. However, these apps do not pay special attention to special groups, but only target the majority of young people and office workers. However, these apps do not pay special attention to special groups, but only target the majority of young people and office workers. In order to fill this gap, we have designed a software called Nong’e Tong, which is specially designed for the elderly and other special groups. The software has a simple and beautiful interface, and is easy to use. It not only provides a lot of special functions, but also can link the elderly’s cell phone with their children’s cell phones to check the health and safety of the elderly at any time. Compared to other software, the application has special features for seniors to ensure that they can use the application easily and quickly

Shaping symmetric Airy beam through binary amplitude modulation for ultralong needle focus

Needle-like electromagnetic field has various advantages for the applications in high-resolution imaging, Raman spectroscopy, as well as long-distance optical transportation. The realization of such field often requires high numerical aperture (NA) objective lens and the transmission masks. We demonstrate an ultralong needle-like focus in the optical range produced with an ordinary lens. This is achieved by focusing a symmetric Airy beam (SAB) generated via binary spectral modulation with a digital micromirror device. Such amplitude modulation technique is able to shape traditional Airy beams, SABs, as well as the dynamic transition modes between the one-dimensional and two-dimensional (2D) symmetric Airy modes. The created 2D SAB was characterized through measurement of the propagating fields with one of the four main lobes blocked by an opaque mask. The 2D SAB was verified to exhibit self-healing property against propagation with the obstructed major lobe reconstructed after a certain distance. We further produced an elongated focal line by concentrating the SAB via lenses with different NAs and achieved an ultralong longitudinal needle focus. The produced long needle focus will be applied in optical, chemical, and biological sciences.Fil: Zhao Xiang, Fang. University of Science and Technology of China; ChinaFil: Yu Xuan, Ren. Shanghai Institutes for Biological Sciences; ChinaFil: Gong, Lei. University of Science and Technology of China; ChinaFil: Vaveliuk, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Centro de Investigaciones Opticas (i); Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; ArgentinaFil: Chen, Yue. University of Science and Technology of China; ChinaFil: Rong De, Lu. University of Science and Technology of China; Chin

An Information Perception-Based Emotion Contagion Model for Fire Evacuation

In fires, people are easier to lose their mind. Panic will lead to irrational behavior and irreparable tragedy. It has great practical significance to make contingency plans for crowd evacuation in fires. However, existing studies about crowd simulation always paid much attention on the crowd density, but little attention on emotional contagion that may cause a panic. Based on settings about information space and information sharing, this paper proposes an emotional contagion model for crowd in panic situations. With the proposed model, a behavior mechanism is constructed for agents in the crowd and a prototype of system is developed for crowd simulation. Experiments are carried out to verify the proposed model. The results showed that the spread of panic not only related to the crowd density and the individual comfort level, but also related to people’s prior knowledge of fire evacuation. The model provides a new way for safety education and evacuation management. It is possible to avoid and reduce unsafe factors in the crowd with the lowest cost