1,107 research outputs found

    Risk assessment using transfer learning for grassland fires

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    © 2019 A new direction of risk assessment research in grassland fire management is data-driven prediction, in which data are collected from particular regions. Since some regions have rich datasets that can easily generate knowledge for risk prediction, and some have no data available, this study addresses how we can leverage the knowledge learned from one grassland risk assessment to assist with a current assessment task. In this paper, we first introduce the transfer learning methodology to map and update risk maps in grassland fire management, and we propose a new grassland fire risk analysis method. In this study, two major grassland areas (Xilingol and Hulunbuir) in northern China are selected as the study areas, and five representative indicators (features) are extracted from grassland fuel, fire climate, accessibility, human and social economy. Taking Xilingol as the source domain (where sufficient labelled data are available) and Hulunbuir as the target domain (which contains insufficient data but requires risk assessment/prediction), we then establish the mapping relationship between grassland fire indicators and the degrees of grassland fire risk by using a transfer learning method. Finally, the fire risk in the Hulunbuir grassland is assessed using the transfer learning method. Experiments show that the prediction accuracy reached 87.5% by using the transfer learning method, representing a significant increase over existing methods

    Effects of transcutaneous electrical nerve stimulation on the regional cerebral blood flow of subjects with stroke : a preliminary study

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    2004-2005 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

    A natural product-like JAK2/STAT3 inhibitor induces apoptosis of malignant melanoma cells

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    The JAK2/STAT3 signaling pathway plays a critical role in tumorigenesis, and has been suggested as a potential molecular target for anti-melanoma therapeutics. However, few JAK2 inhibitors were being tested for melanoma therapy. In this study, eight amentoflavone analogues were evaluated for their activity against human malignant melanoma cells. The most potent analogue, compound 1, inhibited the phosphorylation of JAK2 and STAT3 in human melanoma cells, but had no discernible effect on total JAK2 and STAT3 levels. A cellular thermal shift assay was performed to identify that JAK2 is engaged by 1 in cell lysates. Moreover, compound 1 showed higher antiproliferative activity against human melanoma A375 cells compared to a panel of cancer and normal cell lines. Compound 1 also activated caspase-3 and cleaved PARP, which are markers of apoptosis, and suppressed the anti-apoptotic Bcl-2 level. Finally, compound 1 induced apoptosis in 80% of treated melanoma cells. To our knowledge, compound 1 is the first amentoflavone-based JAK2 inhibitor to be investigated for use as an anti-melanoma agent.published_or_final_versio

    An activity-based integrated land-use transport model for urban spatial distribution simulation

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    This research develops an activity-based integrated land use/transport interaction model based on the concepts – activities (mainly, households and employment activities), activity location and relocation for Chinese regions. It consists of a residential and employment location sub-model, a transport sub-model and an implicit real estate rent adjustment sub-model. The model is developed to model the urban activity distribution evolution, predict urban spatial development trends and examine various planning decision implications. It spatially distributes household and employment activity change of a study area by zone based on the current activity distribution, land use policies and the accessibilities of the zones. The model is subsequently calibrated to predict the distribution of households and employment activities in Beijing metropolitan area in 2025. Model results show that the resident and employment densities are still high in central Beijing in 2025, and most zones’ resident densities are higher than their employment densities. However, there is also significant population density increase along the 6th ring road, indicating the relocation trend of the residents and businesses to the outskirts. This is consistent with the government objectives to decentralize activities within the central urban area. The paper also suggests that the model should be used mainly in examining the possible differences arising from the adoption of different policies though predicting future of a city distribution proves feasible

    Molecular Phylogenetic Analysis of the Stegana ornatipes Species Group (Diptera: Drosophilidae) in China, with Description of a New Species

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    A new species of the Stegana (Steganina) ornatipes species group (Diptera: Drosophilidae) is described from Hainan, China, S. (S.) xipengi sp. nov. Based on the mitochondrial ND2 and COI gene sequences, the relationships among eight species from mainland China of the ornatipes group, and their relationships to the undulata, nigrolimbata and shirozui species groups of the same subgenus, are investigated, using two species of the subgenus Stegana, S. emeiensis and S. quadrata, as outgroups. The result shows that S. (S.) mengla is debarred from the ornatipes group

    Structure of hadron resonances with a nearby zero of the amplitude

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    We discuss the relation between the analytic structure of the scattering amplitude and the origin of an eigenstate represented by a pole of the amplitude.If the eigenstate is not dynamically generated by the interaction in the channel of interest, the residue of the pole vanishes in the zero coupling limit. Based on the topological nature of the phase of the scattering amplitude, we show that the pole must encounter with the Castillejo-Dalitz-Dyson (CDD) zero in this limit. It is concluded that the dynamical component of the eigenstate is small if a CDD zero exists near the eigenstate pole. We show that the line shape of the resonance is distorted from the Breit-Wigner form as an observable consequence of the nearby CDD zero. Finally, studying the positions of poles and CDD zeros of the KbarN-piSigma amplitude, we discuss the origin of the eigenstates in the Lambda(1405) region.Comment: 7 pages, 3 figures, v2: published versio
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