Spatio-Temporal Calibration for Omni-Directional Vehicle-Mounted

We present a solution to the problem of spatio-temporal calibration for event cameras mounted on an onmi-directional vehicle. Different from traditional methods that typically determine the camera's pose with respect to the vehicle's body frame using alignment of trajectories, our approach leverages the kinematic correlation of two sets of linear velocity estimates from event data and wheel odometers, respectively. The overall calibration task consists of estimating the underlying temporal offset between the two heterogeneous sensors, and furthermore, recovering the extrinsic rotation that defines the linear relationship between the two sets of velocity estimates. The first sub-problem is formulated as an optimization one, which looks for the optimal temporal offset that maximizes a correlation measurement invariant to arbitrary linear transformation. Once the temporal offset is compensated, the extrinsic rotation can be worked out with an iterative closed-form solver that incrementally registers associated linear velocity estimates. The proposed algorithm is proved effective on both synthetic data and real data, outperforming traditional methods based on alignment of trajectories

Systematic Identification of Synergistic Drug Pairs Targeting HIV

The systematic identification of effective drug combinations has been hindered by the unavailability of methods that can explore the large combinatorial search space of drug interactions. Here we present a multiplex screening method named MuSIC (Multiplex Screening for Interacting Compounds), which expedites the comprehensive assessment of pair-wise compound interactions. We examined ~500,000 drug pairs from 1000 FDA-approved or clinically tested drugs and identified drugs that synergize to inhibit HIV replication. Our analysis reveals an enrichment of anti-inflammatory drugs in drug combinations that synergize against HIV, indicating HIV benefits from inflammation that accompanies its infection. Multiple drug pairs identified in this study, including glucocorticoid and nitazoxanide, synergize by targeting different steps of the HIV life cycle. As inflammation accompanies HIV infection, our findings indicate that inhibiting inflammation could curb HIV propagation. MuSIC can be applied to a wide variety of disease-relevant screens to facilitate efficient identification of compound combinations

Supercapacitors (electrochemical capacitors)

International audienceRapid development of the technologies based on electric energy in the last decades have stimulated intensive research on efficient power sources. Electrochemical energy conversion and storage systems are based on Faradaic reactions (charge transfer) and electrostatic attraction of ions at the electrode/electrolyte interface. The latter might be an interesting solution for applications requiring moderate energy density, high power rates, and long cycle life. Electrochemical capacitors (ECs) store the charge in a physical manner, hence, their energy density is moderate. At the same time, the lack of electrochemical reactions ensures very high power and long cycle life compared to batteries. Activated carbons with their versatile properties (like specific surface area, well-developed and suitable porosity, heteroatoms in the graphene matrix) are the most popular materials in EC application. This chapter provides a comprehensive overview of the carbon-based materials recently developed, with special attention devoted to those obtained by biomass carbonization and activation. Electrochemical properties demonstrated by such carbons are discussed in respect to their physicochemical characteristic

Comprehensive molecular characterization of gastric adenocarcinoma

Gastric cancer is a leading cause of cancer deaths, but analysis of its molecular and clinical characteristics has been complicated by histological and aetiological heterogeneity. Here we describe a comprehensive molecular evaluation of 295 primary gastric adenocarcinomas as part of The Cancer Genome Atlas (TCGA) project. We propose a molecular classification dividing gastric cancer into four subtypes: tumours positive for Epstein–Barr virus, which display recurrent PIK3CA mutations, extreme DNA hypermethylation, and amplification of JAK2, CD274 (also known as PD-L1) and PDCD1LG2 (also knownasPD-L2); microsatellite unstable tumours, which show elevated mutation rates, including mutations of genes encoding targetable oncogenic signalling proteins; genomically stable tumours, which are enriched for the diffuse histological variant and mutations of RHOA or fusions involving RHO-family GTPase-activating proteins; and tumours with chromosomal instability, which show marked aneuploidy and focal amplification of receptor tyrosine kinases. Identification of these subtypes provides a roadmap for patient stratification and trials of targeted therapies

Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin

Recent genomic analyses of pathologically-defined tumor types identify “within-a-tissue” disease subtypes. However, the extent to which genomic signatures are shared across tissues is still unclear. We performed an integrative analysis using five genome-wide platforms and one proteomic platform on 3,527 specimens from 12 cancer types, revealing a unified classification into 11 major subtypes. Five subtypes were nearly identical to their tissue-of-origin counterparts, but several distinct cancer types were found to converge into common subtypes. Lung squamous, head & neck, and a subset of bladder cancers coalesced into one subtype typified by TP53 alterations, TP63 amplifications, and high expression of immune and proliferation pathway genes. Of note, bladder cancers split into three pan-cancer subtypes. The multi-platform classification, while correlated with tissue-of-origin, provides independent information for predicting clinical outcomes. All datasets are available for data-mining from a unified resource to support further biological discoveries and insights into novel therapeutic strategies

Assessing the Implementation and Impact of Spokane County DUI Court

DUI/DWI Court is a relatively new approach that addresses the dangerous conduct of driving under the influence or driving while impaired. It aims to reform chronically impaired drivers by holding offenders accountable and providing treatment for their criminogenic needs. Previous literature, in general, suggests this specialty court is more effective than traditional approaches, but some of the most rigorous studies produced different outcomes. There is also very limited information on the outcome of making this intervention mandatory for all eligible offenders.This dissertation studies the implementation and effectiveness of a mandatory DUI court—Spokane County DUI Court. The findings show this DUI court is a relatively high-integrity program. It follows most of the best-practice protocol for DUI courts but has several major limitations in its implementation. However, multivariate survival analyses show this program is not more effective than traditional probation in rehabilitating repeated DUI offenders. The reasons why this program is not as successful as expected are explored and policy implementations for DUI courts nationwide are discussed

Social support and the gendered experience of incarceration in South Korean prisons

Although many studies on social support have demonstrated promising evidence of positive outcomes in a variety of criminal justice settings, not enough empirical research has been conducted on gender effects in a prison setting. Using a sample of 359 Korean inmates (303 men and 56 women), this study examines whether social support lessens involvement in prison misconduct and whether male and female inmates are similarly affected. The findings indicate that female inmates are less likely to engage in misconduct than male inmates. In addition, whereas male inmates are provided with more institutional social support than female inmates, female inmates are more likely to be provided with more informal social support than male inmates. Implications for further research and correctional policy are discussed