Anatomy-specific classification of medical images using deep convolutional nets

Automated classification of human anatomy is an important prerequisite for many computer-aided diagnosis systems. The spatial complexity and variability of anatomy throughout the human body makes classification difficult. "Deep learning" methods such as convolutional networks (ConvNets) outperform other state-of-the-art methods in image classification tasks. In this work, we present a method for organ- or body-part-specific anatomical classification of medical images acquired using computed tomography (CT) with ConvNets. We train a ConvNet, using 4,298 separate axial 2D key-images to learn 5 anatomical classes. Key-images were mined from a hospital PACS archive, using a set of 1,675 patients. We show that a data augmentation approach can help to enrich the data set and improve classification performance. Using ConvNets and data augmentation, we achieve anatomy-specific classification error of 5.9 % and area-under-the-curve (AUC) values of an average of 0.998 in testing. We demonstrate that deep learning can be used to train very reliable and accurate classifiers that could initialize further computer-aided diagnosis.Comment: Presented at: 2015 IEEE International Symposium on Biomedical Imaging, April 16-19, 2015, New York Marriott at Brooklyn Bridge, NY, US

On the Performance Prediction of BLAS-based Tensor Contractions

Tensor operations are surging as the computational building blocks for a variety of scientific simulations and the development of high-performance kernels for such operations is known to be a challenging task. While for operations on one- and two-dimensional tensors there exist standardized interfaces and highly-optimized libraries (BLAS), for higher dimensional tensors neither standards nor highly-tuned implementations exist yet. In this paper, we consider contractions between two tensors of arbitrary dimensionality and take on the challenge of generating high-performance implementations by resorting to sequences of BLAS kernels. The approach consists in breaking the contraction down into operations that only involve matrices or vectors. Since in general there are many alternative ways of decomposing a contraction, we are able to methodically derive a large family of algorithms. The main contribution of this paper is a systematic methodology to accurately identify the fastest algorithms in the bunch, without executing them. The goal is instead accomplished with the help of a set of cache-aware micro-benchmarks for the underlying BLAS kernels. The predictions we construct from such benchmarks allow us to reliably single out the best-performing algorithms in a tiny fraction of the time taken by the direct execution of the algorithms.Comment: Submitted to PMBS1

Doping-Dependent Raman Resonance in the Model High-Temperature Superconductor HgBa2CuO4+d

We study the model high-temperature superconductor HgBa2CuO4+d with electronic Raman scattering and optical ellipsometry over a wide doping range. The resonant Raman condition which enhances the scattering cross section of "two-magnon" excitations is found to change strongly with doping, and it corresponds to a rearrangement of inter-band optical transitions in the 1-3 eV range seen by ellipsometry. This unexpected change of the resonance condition allows us to reconcile the apparent discrepancy between Raman and x-ray detection of magnetic fluctuations in superconducting cuprates. Intriguingly, the strongest variation occurs across the doping level where the antinodal superconducting gap reaches its maximum.Comment: 4 pages, 4 figures, contact authors for Supplemental Materia

Momentum-dependent charge correlations in YBa2_2Cu3_3O6+δ_{6+\delta} superconductors probed by resonant x-ray scattering: Evidence for three competing phases

We have used resonant x-ray scattering to determine the momentum dependent charge correlations in YBa$_2$Cu$_3$O$_{6.55}$ samples with highly ordered chain arrays of oxygen acceptors (ortho-II structure). The results reveal nearly critical, biaxial charge density wave (CDW) correlations at in-plane wave vectors (0.315, 0) and (0, 0.325). The corresponding scattering intensity exhibits a strong uniaxial anisotropy. The CDW amplitude and correlation length are enhanced as superconductivity is weakened by an external magnetic field. Analogous experiments were carried out on a YBa$_2$Cu$_3$O$_{6.6}$ crystal with a dilute concentration of spinless (Zn) impurities, which had earlier been shown to nucleate incommensurate magnetic order. Compared to pristine crystals with the same doping level, the CDW amplitude and correlation length were found to be strongly reduced. These results indicate a three-phase competition between spin-modulated, charge-modulated, and superconducting states in underdoped YBa$_2$Cu$_3$O$_{6+\delta}$.Comment: 6 pages, 3 figures revised version, to appear in Phys. Rev. Let

Collective nature of spin excitations in superconducting cuprates probed by resonant inelastic x-ray scattering

We used resonant inelastic x-ray scattering (RIXS) with and without analysis of the scattered photon polarization, to study dispersive spin excitations in the high temperature superconductor YBa2Cu3O6+x over a wide range of doping levels (0.1 < x < 1). The excitation profiles were carefully monitored as the incident photon energy was detuned from the resonant condition, and the spin excitation energy was found to be independent of detuning for all x. These findings demonstrate that the largest fraction of the spin-flip RIXS profiles in doped cuprates arises from magnetic collective modes, rather than from incoherent particle-hole excitations as recently suggested theoretically [Benjamin et al. Phys. Rev. Lett. 112, 247002(2014)]. Implications for the theoretical description of the electron system in the cuprates are discussed.Comment: Supplementary materials are available upon reques

Detecting Determinacy in Prolog Programs: 22nd International Conference, ICLP 2006, Seattle, WA, USA, August 17-20, 2006. Proceedings

In program development it is useful to know that a call to a Prolog program will not inadvertently leave a choice-point on the stack. Determinacy inference has been proposed for solving this problem yet the analysis was found to be wanting in that it could not infer determinacy conditions for programs that contained cuts or applied certain tests to select a clause. This paper shows how to remedy these serious deficiencies. It also addresses the problem of identifying those predicates which can be rewritten in a more deterministic fashion. To this end, a radically new form of determinacy inference is introduced, which is founded on ideas in ccp, that is capable of reasoning about the way bindings imposed by a rightmost goal can make a leftmost goal deterministic

Медицинская экспертиза жизнеспособности в деятельности семейного врача

Nicolae Testemitanu Department of Social Medicine and Management, Nicolae Testemitanu State Medical and Pharmaceutical University, Congresul III al Medicilor de Familie din Republica Moldova, 17–18 mai, 2012, Chişinău, Republica Moldova, Conferinţa Naţională „Maladii bronhoobstructive la copii”, consacrată profesorului universitar, doctor habilitat Victor Gheţeul, 27 aprilie, Chişinău, Republica MoldovaVitality medical expertise directly affects health indices including a population’s disability. The current problems of Vitality medical expertise are related to the accuracy of examination, respect of laws and the rights of surveyed persons, the problems of rehabilitation and restoring the people suffering in the socio-economic activity, as well as reintegration of persons with disabilities into family life, social, and professional field. Vitality medical expertise is a medico-social activity carried out by medical professionals who appreciate the surveyed person’s ability to fulfill his/her role in social and professional functions.Медицинская экспертиза жизнеспособности играет важную роль в поддержании показателей здоровья населения, включительно показателей инвалидности. Актуальность задач медицинской экспертизы жизнеспособности включают правильность экспертизы, соблюдение законности, соблюдение прав экспертируемых лиц, задачи реабилитации и реинтеграции больных в социально-экономической деятельности, а также реинтеграции инвалидов в семье, обществе и профессиональной деятельности. Медицинская экспертиза жизнеспособности это медикосоциальная деятельность, проводимая врачами профессионалами, которая определяет способность экспертируемого лица выполнять свои социальные и профессиональные роли и задачи

Abrupt Onset of Second Energy Gap at Superconducting Transition of Underdoped Bi2212

The superconducting gap - an energy scale tied to the superconducting phenomena-opens on the Fermi surface at the superconducting transition temperature (TC) in conventional BCS superconductors. Quite differently, in underdoped high-TC superconducting cuprates, a pseudogap, whose relation to the superconducting gap remains a mystery, develops well above TC. Whether the pseudogap is a distinct phenomenon or the incoherent continuation of the superconducting gap above TC is one of the central questions in high-TC research. While some experimental evidence suggests they are distinct, this issue is still under intense debate. A crucial piece of evidence to firmly establish this two-gap picture is still missing: a direct and unambiguous observation of a single-particle gap tied to the superconducting transition as function of temperature. Here we report the discovery of such an energy gap in underdoped Bi2212 in the momentum space region overlooked in previous measurements. Near the diagonal of Cu-O bond direction (nodal direction), we found a gap which opens at TC and exhibits a canonical (BCS-like) temperature dependence accompanied by the appearance of the so-called Bogoliubov quasiparticles, a classical signature of superconductivity. This is in sharp contrast to the pseudogap near the Cu-O bond direction (antinodal region) measured in earlier experiments. The emerging two-gap phenomenon points to a picture of richer quantum configurations in high temperature superconductors.Comment: 16 pages, 4 figures, authors' version Corrected typos in the abstrac

MCG+00-32-16: An Irregular Galaxy Close to the Lowest Redshift Absorber on the 3C 273 Line of Sight

MCG+00-32-16 is the galaxy closest in position-velocity space to the lowest redshift Ly$\alpha$ absorber along the line-of-sight to the quasar 3C 273. Its projected separation is 204 (d/19 Mpc) kpc, where d is the distance from the Milky Way to the galaxy, and the redshift difference is only 94 km/s; HI 1225+01 is slightly closer in projected separation to the absorber, but has a greater redshift difference. We present HI synthesis array mapping and CCD photometry in B and R for MCG+00-32-16. The HI disk is rotating in such a way that the side of the galaxy closer to the sight-line to the quasar has the larger velocity difference from the absorber. The absorber may be a ``failed dwarf'' member of a poor galaxy group of which MCG+00-32-16 and HI 1225+01 are the only members to have formed stars.Comment: 14 pages, 9 figures, accepted by Astrophysical Journa