Dentin Regeneration

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66570/2/10.1177_08959374950090030501.pd

Synthesis and anti-norovirus activity of pyranobenzopyrone compounds

During the last decade, noroviruses have gained media attention as the cause of large scale outbreaks of gastroenteritis on cruise ships, dormitories, nursing homes, etc. Although noroviruses do not multiply in food or water, they can cause large outbreaks because approximately 10–100 virions are sufficient to cause illness in a healthy adult. Recently, it was shown that the activity of acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT1) enzyme may be important in norovirus infection. In search of anti-noroviral agents based on the inhibition of ACAT1, we synthesized and evaluated the inhibitory activities of a class of pyranobenzopyrone molecules containing amino, pyridine, substituted quinolines, or 7,8-benzoquinoline nucleus. Three of the sixteen evaluated compounds possess ED[subscript]5[subscript]0 values in the low micrometer range. 2-Quinolylmethyl derivative 3A and 4-quinolylmethyl derivative 4A showed ED[subscript]5[subscript]0 values of 3.4 and 2.4 [mu]M and TD[subscript]5[subscript]0 values of >200 and 96.4 [mu]M, respectively. The identified active compounds are suitable for further modification for the development of anti-norovirus agents

Syntheses, neural protective activities, and inhibition of glycogen synthase kinase-3beta of substituted quinolines.

A new series of fifteen 5-, 6-, and 8-appended 4-methylquinolines were synthesized and evaluated for their neural protective activities. Selected compounds were further examined for their inhibition of glycogen synthase kinase-3β (GSK-3β) and protein kinase C (PKC). Two most potent analogs, compounds 3 and 10, show nanomolar protective activities in amyloid β-induced MC65 cells and enzymatic inhibitory activities against GSK-3β, but poor PKC inhibitory activities. Using normal mouse model, the distribution of the most potent analog 3 in various tissues and possible toxic effects in the locomotors and inhibition of liver transaminases activities were carried out. No apparent decline of locomotor activity and no inhibition of liver transaminases were found. The compound appears to be safe for long-term use in Alzheimer’s disease mouse model

A new method for the assessment of traction enhancers and the generation of organic layers in a twin-disc machine

Low adhesion presents a major concern for many rail operators. Railway vehicles under these circumstances can experience a serious loss of braking capability giving rise to dangerous situations such as platform overruns and signals passed at danger. One cause of adhesion loss is autumn leaf fall [1]. Leaves are run over by the wheels of a train and a chemical reaction occurs between the leaf and the rail steel [2]. This forms a black layer on the rail which when wet causes very low friction. These leaf layers have also been shown to be isolating and can interfere with railway signalling systems. Traction enhancers (also referred to in this paper as traction gels) have been developed as an alternative solution to using sand alone. They consist of sand particles suspended in a water based gel and are designed to be delivered to the rail by the trackside or via mobile application systems. The aim of this work was to develop a technique for generating a representative leaf layer on the surface of a twin-disc rail specimen and using this to develop a test methodology for assessing the performance of a traction gel in terms of adhesion recovery, wear and its effect on wheel/rail isolation

Comparative design study of a diesel exhaust gas heat exchanger for truck applications with conventional and state of the art heat transfer enhancements

The exhaust gas of heavy duty diesel engines can provide an important heat source that may be used in a number of ways to provide additional power and improve overall engine efficiency. The sizing of a heat exchanger that can manage the heat load and still be of reasonable size and weight without excessive pressure drop is of significant importance especially for truck applications. This is the subject of the present work. To approach the problem, a total of five different configurations are investigated and a comparison of conventional and state of the art heat transfer enhancement technologies is included. Two groups of configurations are examined: (a) a classical shell and tube heat exchanger using staggered cross-flow tube bundles with smooth circular tubes, finned tubes and tubes with dimpled surfaces and (b) a cross-flow plate heat exchanger, initially with finned surfaces on the exhaust gas side and then with 10 ppi and 40 ppi metal foam material substituting for the fins. Calculations were performed, using established heat exchanger design methodologies and recently published data from the literature to size the aforementioned configurations. The solutions provided reduce the overall heat exchanger size, with the plate and fin type consisting of plain fins presenting the minimum pressure drop (up to 98% reduction compared to the other configurations), and the 40 ppi metal foam being the most compact in terms of size and weight. Durability of the solutions is another issue which will be examined in a future investigation. However, coupling of the exhaust heat exchanger after a particulate trap appears to be the most promising solution to avoid clogging from soot accumulation

miR-23~27~24 clusters control effector T cell differentiation and function

Coordinated repression of gene expression by evolutionarily conserved microRNA (miRNA) clusters and paralogs ensures that miRNAs efficiently exert their biological impact. Combining both loss- and gain-of-function genetic approaches, we show that the miR-23~27~24 clusters regulate multiple aspects of T cell biology, particularly helper T (Th) 2 immunity. Low expression of this miRNA family confers proper effector T cell function at both physiological and pathological settings. Further studies in T cells with exaggerated regulation by individual members of the miR-23~27~24 clusters revealed that miR-24 and miR-27 collaboratively limit Th2 responses through targeting IL-4 and GATA3 in both direct and indirect manners. Intriguingly, although overexpression of the entire miR-23 cluster also negatively impacts other Th lineages, enforced expression of miR-24, in contrast to miR-23 and miR-27, actually promotes the differentiation of Th1, Th17, and induced regulatory T cells, implying that under certain conditions, miRNA families can fine tune the biological effects of their regulation by having individual members antagonize rather than cooperate with each other. Together, our results identify a miRNA family with important immunological roles and suggest that tight regulation of miR-23~27~24 clusters in T cells is required to maintain optimal effector function and to prevent aberrant immune responses

Quantum state engineering assisted by entanglement

We suggest a general scheme for quantum state engineering based on conditional measurements carried out on entangled twin-beam of radiation. Realistic detection schemes such as {\sc on/off} photodetection, homodyne detection and joint measurement of two-mode quadratures are analyzed in details. Imperfections of the apparatuses, such as nonunit quantum efficiency and finite resolution, are taken into account. We show that conditional {\sc on/off} photodetection provides a reliable scheme to verify nonclassicality, whereas conditional homodyning represents a tunable and robust source of squeezed light. We also describe optical teleportation as a conditional measurement, and evaluate the degrading effects of finite amount of entanglement, decoherence due to losses, and nonunit quantum efficiency.Comment: Some pics with low resolution. Originals at http://www.qubit.i

Robustness of nonclassical superpositions states against decoherence

We make a comparative study of quadrature squeezing, photon-number distribution and Wigner function in a decayed quantum system. Specifically, for a field mode prepared initially in cat states interacting with a zero-temperature environment, we show that the rate of reduction of the nonclassical effects in this system is proportional to the occurrence of the decoherence process.Comment: 11 pages, 4 figure

Interatomic potentials for atomistic simulations of the Ti-Al system

Semi-empirical interatomic potentials have been developed for Al, alpha-Ti, and gamma-TiAl within the embedded atomic method (EAM) by fitting to a large database of experimental as well as ab-initio data. The ab-initio calculations were performed by the linear augmented plane wave (LAPW) method within the density functional theory to obtain the equations of state for a number of crystal structures of the Ti-Al system. Some of the calculated LAPW energies were used for fitting the potentials while others for examining their quality. The potentials correctly predict the equilibrium crystal structures of the phases and accurately reproduce their basic lattice properties. The potentials are applied to calculate the energies of point defects, surfaces, planar faults in the equilibrium structures. Unlike earlier EAM potentials for the Ti-Al system, the proposed potentials provide reasonable description of the lattice thermal expansion, demonstrating their usefulness in the molecular dynamics or Monte Carlo studies at high temperatures. The energy along the tetragonal deformation path (Bain transformation) in gamma-TiAl calculated with the EAM potential is in a fairly good agreement with LAPW calculations. Equilibrium point defect concentrations in gamma-TiAl are studied using the EAM potential. It is found that antisite defects strongly dominate over vacancies at all compositions around stoichiometry, indicating that gamm-TiAl is an antisite disorder compound in agreement with experimental data.Comment: 46 pages, 6 figures (Physical Review B, in press