REPENSAR LA GRÁFICA IDENTIFICATIVA CON RECURRENCIAS COMUNICACIONALES DE RECONOCIMIENTO HISTÓRICO EN EL DISEÑO URBANO

La memoria gráfica identificativa materializada representa, culturalmente, al diseño urbano que está expuesto en fachadas de diversas edificaciones del siglo XX, que tienen características comunicacionales, en México. Esa materialidad comunicativa ha sido discutida a partir de la observación reflexiva y crítica en sectores históricos con efectos de sentido contenidos en costumbres, tradiciones y hábitos, que forman parte de la identidad cultural en su realidad social. Este estudio, que se encuentra en inicios posdoctorales, se propone dar cuenta de recurrencias gráfico-comunicativas que puedan encauzar la reglamentación urbana, para una mejor calidad de vida del sujeto social.  Palabras clave: Materialidad gráfica, comunicación, diseño identificativo manual. AbstractThe materialized graphic identification memory culturally represents the urban design exposed on the facades of various buildings with communication characteristics in Mexico. This communicative materiality has been discussed from the reflexive and critical observation in historical sectors with effects of meaning contained in customs, traditions and habits that are part of the cultural identity in its social reality. This study, which is in postdoctoral beginnings, intends to account for graphic-communicative recurrences that can channel urban regulations for a better quality of life of the social subject. Keywords: Graphic materiality, communication, manual identification design

Hibridaciones culturales en la gráfica corporativa de microempresas ante una influencia hegemónica estadounidense en la ciudad de Tampico-México de 1994 a 2016

Al paso de los años, la frontera norte de México con Estados Unidos ha tenido una serie de transformaciones socioculturales y del paisaje urbano. Bajo esa premisa, este estudio de investigación pretende analizar a partir de la historia, las transformaciones culturales y comunicacionales que ha tenido el diseño corporativo en la cartelería urbana de algunas microempresas representativas en esa sociedad de consumo. Buscando así generar un marco referencial que pueda encauzar las políticas públicas orientadas por la cultura como motor de cohesión social, identidad local y promoción de valores

Discurso narrativo social de poder en anuncios indicadores como dispositivos de seguridad globales en el espacio público de México

This critical reflection puts into dialogue the globalization with an impact on Mexico during the year 2000 to 2010, read from indicative advertisements implemented in public streets as part of the social narrative discourse. The sample of particular cases of revised graphic-identifying advertisements supposes a group of local and multinational businesses that maintained an emancipatory process, which tangentially exposes the temporal and spatial political-economic power in that country. Precisely, the accumulation of graphic communication elements altered the lifestyle in that society and its urban landscape. Hence, the review of this study with a historical approach allowed the differentiation of transformation and permanence traits of design objects, with categories and characteristics observed and narrated as materialized representations in response to the impact of globalization. The conclusions obtained expose the designs as narrating communicational elements of political-social power exercised that problematize power as a determining factor of urban space.Esta reflexión crítica pone en diálogo la globalización con impacto en México durante el año 2000 al 2010, leída a partir de anuncios indicadores implementados en la vía pública como parte del discurso narrativo social. La muestra de casos particulares de anuncios gráficos-idendicativos revisados supone un grupo de comercios locales y multinacionales que mantuvieron un proceso emancipatorio, lo que expone tangencialmente el poder político-económico temporal y espacial en ese país. Precisamente, la acumulación de elementos gráficos comunicacionales alteró el estilo de vida en esa sociedad y su paisaje urbano. De ahí que, la revisión de este estudio con enfoque histórico permitió la diferenciación de rasgos de transformación y permanencia de los objetos de diseño, con categorías y características observadas y narradas como representaciones materializadas en respuesta del impacto de globalización. Las conclusiones obtenidas exponen los diseños como elementos comunicacionales narradores de poderío ejercido político-social que problematizan el poder como factor determinante del espacio urbano.Esta reflexão crítica coloca em diálogo a globalização com impacto no México durante os anos de 2000 a 2010, lida a partir de anúncios indicativos implementados em vias públicas como parte do discurso narrativo social. A amostra de casos particulares de anúncios gráficos-identificadores revisados supõe um conjunto de empresas locais e multinacionais que mantiveram um processo emancipatório, que expõe tangencialmente o poder político-econômico temporal e espacial daquele país. Precisamente, o acúmulo de elementos de comunicação gráfica alterou o estilo de vida daquela sociedade e sua paisagem urbana. Assim, a revisão deste estudo com uma abordagem histórica permitiu diferenciar os traços de transformação e permanência dos objetos de design, com categorias e características observadas e narradas como representações materializadas em resposta ao impacto da globalização. As conclusões obtidas expõem os projetos como narradores de elementos comunicacionais do poder político-social exercido que problematizam o poder como fator determinante do espaço urbano

Disputa entre la materialidad arquitectónica y la imagen gráfica

The following article derived from the findings obtained from the field work carried out in the Thesis of the Doctorate of Design of the University of Palermo by one of the authors, Dr. Rebeca Lozano (2018). In relation to this, data obtained on the perception of the architect and graphic designer are presented in their joint work area for the commercial facades in the city of Tampico, Mexico. It was thoughtful to think of the work carried out by professionals of these two disciplines in the approach and architectural execution, but also in the visual result of communication between architecture and graphic design. Commercial buildings were considered from their design planning, construction, structural functionality, to internal signage. However, that did not happen when it came to linking with the identifying-corporate graphic design on the commercial facade. Particular case studies were identified, with disengagement in their visual-communicative production as an important factor in the process of commercial architectural planning-construction. The conclusions obtained represent a reference framework for guiding the inclusive planninglinkage between the architecture and commercial graphic design exposed on public roads, which can guide the identification and social significance of the culture of Tampico.El siguiente artículo derivó de los hallazgos obtenidos del trabajo de campo realizado en la Tesis del Doctorado de Diseño de la Universidad de Palermo de una de las autoras, la doctora Rebeca Lozano Castro (2018). Con relación a eso, se presentan datos obtenidos sobre la percepción del arquitecto y el diseñador gráfico en su área de trabajo conjunto para las fachadas comerciales en la ciudad de Tampico, México. Fue reflexivo pensar en el trabajo llevado a cabo por profesionales de esas dos disciplinas en el planteamiento y la ejecución arquitectónica, pero también en el resultado visual de la comunicación entre la arquitectura y el diseño gráfico. Las edificaciones comerciales fueron consideradas desde su planeación de diseño, construcción, funcionalidad estructural, hasta la señalética interna. Sin embargo, eso no sucedió cuando se trató de la vinculación con el diseño gráfico identificativo-corporativo en la fachO artigo a seguir derivou dos resultados obtidos a partir do trabalho de campo realizado na Tese do Doutorado em Design da Universidade de Palermo por um dos autores, Dr. Rebeca Lozano Castro (2018). Em relação a isso, os dados obtidos sobre a percepção do arquiteto e designer gráfico são apresentados em sua área de trabalho conjunto para as fachadas comerciais na cidade de Tampico, México. Foi atencioso pensar no trabalho realizado por profissionais dessas duas disciplinas na abordagem e execução da comercial. Se identificaron casos de estudio particulares, con desvinculación en su producción visual-comunicacional como factor importante en el proceso de planeación-construcción arquitectónica comercial. Las conclusiones obtenidas representan un marco referencial para encauzar la planeaciónvinculación inclusiva entre la arquitectura y el diseño gráfico comercial expuesto en la vía pública, que pueda orientar la identificación y significación social de la cultura de Tampico. Palabras clave: Diseño Gráfico Corporativo, Arquitectura, Identificación.O artigo a seguir derivou dos resultados obtidos a partir do trabalho de campo realizado na Tese do Doutorado em Design da Universidade de Palermo por um dos autores, Dr. Rebeca Lozano Castro (2018). Em relação a isso, os dados obtidos sobre a percepção do arquiteto e designer gráfico são apresentados em sua área de trabalho conjunto para as fachadas comerciais na cidade de Tampico, México. Foi atencioso pensar no trabalho realizado por profissionais dessas duas disciplinas na abordagem e execução arquitetônica, mas também no resultado visual da comunicação entre arquitetura e design gráfico. Os edifícios comerciais foram considerados desde o seu planeamento de projeto, construção, funcionalidade estrutural, para sinalização interna. No entanto, isso não aconteceu quando se tratava de ligação com o design gráfico de identificação corporativa na fachada comercial. Foram identificados estudos de caso específicos, com desengajamento em sua produção visual-comunicativa como um fator importante no processo de planejamento arquitetônico comercial-construção. As conclusões obtidas representam um quadro de referência para orientar a inclusão do planejamento-ligação entre a arquitetura e o design gráfico comercial expostos nas vias públicas, o que pode orientar a identificação e o significado social da cultura da Tampico

Reflexión gráfica identificativa comercial en marquesinas del patrimonio edificado con exclusión modernizante en Tampico, Tamaulipas, México

This critical reflection puts social exclusion in dialogue through canopies with commercial identification graphics that are part of the historiography of Tamaulipas in Mexico.Esta reflexión crítica pone en diálogo la exclusión social por medio de marquesinas con gráficas indentificativas comerciales que forman parte de la historiografía de Tamaulipas en México. Esta reflexão crítica coloca a exclusão social em diálogo por meio de toldos com gráficos de identificação comercial que fazem parte da historiografia de Tamaulipas no México.&nbsp

Assessment of a New ROS1 Immunohistochemistry Clone (SP384) for the Identification of ROS1 Rearrangements in Patients with Non–Small Cell Lung Carcinoma: the ROSING Study

Introduction: The ROS1 gene rearrangement has become an important biomarker in NSCLC. The College of American Pathologists/International Association for the Study of Lung Cancer/Association for Molecular Pathology testing guidelines support the use of ROS1 immunohistochemistry (IHC) as a screening test, followed by confirmation with fluorescence in situ hybridization (FISH) or a molecular test in all positive results. We have evaluated a novel anti-ROS1 IHC antibody (SP384) in a large multicenter series to obtain real-world data. Methods: A total of 43 ROS1 FISH-positive and 193 ROS1 FISH-negative NSCLC samples were studied. All specimens were screened by using two antibodies (clone D4D6 from Cell Signaling Technology and clone SP384 from Ventana Medical Systems), and the different interpretation criteria were compared with break-apart FISH (Vysis). FISH-positive samples were also analyzed with next-generation sequencing (Oncomine Dx Target Test Panel, Thermo Fisher Scientific). Results: An H-score of 150 or higher or the presence of at least 70% of tumor cells with an intensity of staining of 2+ or higher by the SP384 clone was the optimal cutoff value (both with 93% sensitivity and 100% specificity). The D4D6 clone showed similar results, with an H-score of at least 100 (91% sensitivity and 100% specificity). ROS1 expression in normal lung was more frequent with use of the SP384 clone (p < 0.0001). The ezrin gene (EZR)-ROS1 variant was associated with membranous staining and an isolated green signal FISH pattern (p = 0.001 and p = 0.017, respectively). Conclusions: The new SP384 ROS1 IHC clone showed excellent sensitivity without compromising specificity, so it is another excellent analytical option for the proposed testing algorithm

VIII Encuentro de Docentes e Investigadores en Historia del Diseño, la Arquitectura y la Ciudad

Acta de congresoLa conmemoración de los cien años de la Reforma Universitaria de 1918 se presentó como una ocasión propicia para debatir el rol de la historia, la teoría y la crítica en la formación y en la práctica profesional de diseñadores, arquitectos y urbanistas. En ese marco el VIII Encuentro de Docentes e Investigadores en Historia del Diseño, la Arquitectura y la Ciudad constituyó un espacio de intercambio y reflexión cuya realización ha sido posible gracias a la colaboración entre Facultades de Arquitectura, Urbanismo y Diseño de la Universidad Nacional y la Facultad de Arquitectura de la Universidad Católica de Córdoba, contando además con la activa participación de mayoría de las Facultades, Centros e Institutos de Historia de la Arquitectura del país y la región. Orientado en su convocatoria tanto a docentes como a estudiantes de Arquitectura y Diseño Industrial de todos los niveles de la FAUD-UNC promovió el debate de ideas a partir de experiencias concretas en instancias tales como mesas temáticas de carácter interdisciplinario, que adoptaron la modalidad de presentación de ponencias, entre otras actividades. En el ámbito de VIII Encuentro, desarrollado en la sede Ciudad Universitaria de Córdoba, se desplegaron numerosas posiciones sobre la enseñanza, la investigación y la formación en historia, teoría y crítica del diseño, la arquitectura y la ciudad; sumándose el aporte realizado a través de sus respectivas conferencias de Ana Clarisa Agüero, Bibiana Cicutti, Fernando Aliata y Alberto Petrina. El conjunto de ponencias que se publican en este Repositorio de la UNC son el resultado de dos intensas jornadas de exposiciones, cuyos contenidos han posibilitado actualizar viejos dilemas y promover nuevos debates. El evento recibió el apoyo de las autoridades de la FAUD-UNC, en especial de la Secretaría de Investigación y de la Biblioteca de nuestra casa, como así también de la Facultad de Arquitectura de la UCC; va para todos ellos un especial agradecimiento

A nomogram for predicting complications in patients with solid tumours and seemingly stable febrile neutropenia

Background: We sought to develop and externally validate a nomogram and web-based calculator to individually predict the development of serious complications in seemingly stable adult patients with solid tumours and episodes of febrile neutropenia (FN). Patients and methods: The data from the FINITE study (n ¼ 1133) and University of Salamanca Hospital (USH) FN registry (n ¼ 296) were used to develop and validate this tool. The main eligibility criterion was the presence of apparent clinical stability, defined as events without acute organ dysfunction, abnormal vital signs, or major infections. Discriminatory ability was measured as the concordance index and stratification into risk groups. Results: The rate of infection-related complications in the FINITE and USH series was 13.4% and 18.6%, respectively. The nomogram used the following covariates: Eastern Cooperative Group (ECOG) Performance Status X2, chronic obstructive pulmonary disease, chronic cardiovascular disease, mucositis of grade X2 (National Cancer Institute Common Toxicity Criteria), monocytes o200/mm3 , and stress-induced hyperglycaemia. The nomogram predictions appeared to be well calibrated in both data sets (Hosmer–Lemeshow test, P40.1). The concordance index was 0.855 and 0.831 in each series. Risk group stratification revealed a significant distinction in the proportion of complications. With a X116-point cutoff, the nomogram yielded the following prognostic indices in the USH registry validation series: 66% sensitivity, 83% specificity, 3.88 positive likelihood ratio, 48% positive predictive value, and 91% negative predictive value. Conclusions: We have developed and externally validated a nomogram and web calculator to predict serious complications that can potentially impact decision-making in patients with seemingly stable FN

Phase II pilot study of the prednisone to dexamethasone switch in metastatic castration-resistant prostate cancer (mCRPC) patients with limited progression on abiraterone plus prednisone (SWITCH study)

BACKGROUND: Despite most metastatic castration-resistant prostate cancer (mCRPC) patients benefit from abiraterone acetate plus prednisone 5 mg bid (AA + P), resistance eventually occurs. Long-term use of prednisone has been suggested as one of the mechanisms driving resistance, which may be reversed by switching to another steroid. METHODS: SWITCH was a single-arm, open-label, single-stage phase II study. The primary objective was to evaluate the antitumour activity of abiraterone acetate plus dexamethasone 0.5 mg daily (AA + D) in mCRPC patients progressing to AA + P. Clinically stable mCRPC patients who had prostate-specific antigen (PSA) and/or limited radiographic progression after at least 12 weeks on AA + P, were eligible. The primary endpoint was measured as the proportion of patients achieving a PSA decline of  ≥ 30% (PSA30) from baseline after 6 weeks on AA + D. Secondary endpoints included: PSA50 response rate at 12 weeks, time to biochemical and radiological progression, overall survival, safety profile evaluation, benefit from subsequent treatment lines and the identification of biomarkers of response (AR copy number, TMPRSS2-ERG status and PTEN expression). RESULTS: Twenty-six patients were enrolled. PSA30 and PSA50 were 46.2% and 34.6%, respectively. Median time to biochemical and radiological progression were 5.3 and 11.8 months, respectively. Two radiological responses were observed. Median overall survival was 20.9 months. Patients with AR gain detected in plasma circulating tumour DNA did not respond to switch, whereas patients with AR normal status benefited the most. No significant toxicities were observed and PSA50 response rate to subsequent taxane was 50%. CONCLUSIONS: In selected clinical stable mCRPC patients with limited disease progression on AA + P, a steroid switch from prednisone to dexamethasone can lead to PSA and radiological responses