A KK-monopole giant graviton in AdS_5 x Y_5

We construct a new giant graviton solution in AdS_5 x Y_5, with Y_5 a quasi-regular Sasaki-Einstein manifold, consisting on a Kaluza-Klein monopole wrapped around the Y_5 and with its Taub-NUT direction in AdS_5. We find that this configuration has minimal energy when put in the centre of AdS_5, where it behaves as a massless particle. When we take Y_5 to be S^5, we provide a microscopical description in terms of multiple gravitational waves expanding into the fuzzy S^5 defined as an S^1 bundle over the fuzzy CP^2. Finally we provide a possible field theory dual interpretation of the construction.Comment: 11 pages, published versio

Photoplethysmographic Waveform in Hyperbaric Environment

The objective of this work is the identification of significant variations of morphological parameters of the photoplethysmographic (PPG) signal when the subjects are exposed to an increase in atmospheric pressure. To achieve this goal, the PPG signal of 26 subjects, exposed to a hyperbaric environment whose pressure increases up to 5 atm, has been recorded. From this record, segments of 4 minutes have been processed at 1 atm, 3 atm and 5 atm, both in the descending (D) and ascending (A) periods of the immersion. In total, four states (3D, 5, 3A and 1A) normalized to the basal state (1D) have been considered. In these segments, six morphological parameters of the PPG signal were studied. The width, the amplitude, the widths of the anacrotic and catacrotic phases, and the upward and downward slopes of each PPG pulse were extracted. The results showed significant increases in the three parameters related to the pulse width. This increase is significant in the four states analysed for the anacrotic phase width. Furthermore, a significant decrease in the amplitude and in both slopes (in the states 1A) was observed. These results show that the PPG width responds rapidly to the increase in pressure, indicating an activation of the sympathetic system, while amplitude and pulse slopes are decreased when the subjects are exposed to the hyperbaric environment for a considerable period of time

A Machine Learning Approach to Predict Healthcare Cost of Breast Cancer Patients

This paper presents a novel machine learning approach to per- form an early prediction of the healthcare cost of breast cancer patients. The learning phase of our prediction method considers the following two steps: i) in the first step, the patients are clustered taking into account the sequences of ac- tions undergoing similar clinical activities and ensuring similar healthcare costs, and ii) a Markov chain is then learned for each group to describe the action- sequences of the patients in the cluster. A two step procedure is undertaken in the prediction phase: i) first, the healthcare cost of a new patient’s treatment is estimated based on the average healthcare cost of its k−nearest neighbors in each group, and ii) finally, an aggregate measure of the healthcare cost estimated by each group is used as the final predicted cost. Experiments undertaken reveal a mean absolute percentage error as small as 6%, even when half of the clinical records of a patient is available, substantiating the early prediction capability of the proposed method. Comparative analysis substantiates the superiority of the proposed algorithm over the state-of-the-art techniques.IT1244-19 PID2019-104966GB-I00 TIN2016-78365-

Type II pp-wave Matrix Models from Point-like Gravitons

The BMN Matrix model can be regarded as a theory of coincident M-theory gravitons, which expand by Myers dielectric effect into the 2-sphere and 5-sphere giant graviton vacua of the theory. In this note we show that, in the same fashion, Matrix String theory in Type IIA pp-wave backgrounds arises from the action for coincident Type IIA gravitons. In Type IIB, we show that the action for coincident gravitons in the maximally supersymmetric pp-wave background gives rise to a Matrix model which supports fuzzy 3-sphere giant graviton vacua with the right behavior in the classical limit. We discuss the relation between our Matrix model and the Tiny Graviton Matrix theory of hep-th/0406214.Comment: 18 page

Branes wrapping black holes as a purely gravitational dielectric effect

In this paper we give a microscopical description of certain configurations of branes wrapping black hole horizons in terms of dielectric gravitational waves. Interestingly, the configurations are stable only due to the gravitational background. Therefore, this constitutes a nice example of purely gravitational dielectric effect.Comment: 17 pages, no figures. JHEP published versio

Terminological challenges in the translation of science documentaries: a case-study

This article aims to describe some of the main terminological problems audiovisual translators have to face when dealing with the translation of science documentaries, specifically in the English-Catalan combination. The first section of the article presents some theoretical concepts which underlie this research and which are taken, for the most part, from Cabré's Communicative Theory of Terminology. Then, specific terminological problems audiovisual translators have to solve are described using the data provided by a corpus of four science documentaries lasting approximately 50 minutes each. These challenges include identifying a term, understanding a term, finding the right equivalent, dealing with the absence of an adequate equivalent, solving denominative variations, choosing between in vivo and in vitro terminology, and overcoming mistranscriptions

The Effect of Balance Training on Postural Control in Patients with Parkinson s Disease Using a Virtual Rehabilitation System

[EN] Objectives: Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by motor clinical alterations among others. Postural problems have serious consequences for patients, not only limiting their daily life but also increasing some risks, like the risk of fall. Inadequate postural control and postural instability is a major problem in PD patients. A Virtual Motor Rehabilitation System (VMR) has been tested in patients with PD in the intervention period. Our pur-pose was to analyze the evolution of the spatial postural control during the intervention period, to see if there are any changes caused precisely by this intervention. Methods: Ten people with PD carried out 15 virtual rehabilitation sessions. We tested a groundbreaking system based on Virtual Motor Rehabilitation in two periods of time (baseline evaluation and final evaluation). In the training sessions, the participants performed a customizable treatment using a low-cost system, the Active Balance Rehabilitation system (ABAR). We stored the pressure performed by the participants every five hundredths of a second, and we analyzed the patients' pressure when they maintained their body on the left, on the right, and in the center in sitting position. Our system was able to measure postural control in every patient in each of the virtual rehabilitation sessions. Results: There are no significant differences in the performance of postural control in any of the positions evaluated throughout the sessions. Moreover, the results show a trend to an improvement in all positions. This improvement is especially remarkable in the left/right positions, which are the most important positions in order to avoid problems such as the risk of fall. With regard to the suitability of the ABAR system, we have found outstanding results in enjoyment, success, clarity, and helpfulness. Conclusions: Although PD is a progressive neurodegenerative disorder, the results demonstrate that patients with PD maintain or even improve their postural control in all positions. We think that the main factor influencing these results is that patients use more of their available cognitive processing to improve their postural control. The ABAR system allows us to make this assumption because the system requires the continuous attention of patients, promoting cognitive processing.This contribution was partially funded by the Gobierno de Aragon, Departamento de Industria e Innovacion, y Fondo Social Europeo "Construyendo Europa desde Aragon" and by the Programa Ibercaja-CAI de Estancias de Investigacion.Albiol-Perez, S.; Gil-Gómez, J.; Muñoz-Tomás, M.; Gil Gómez, H.; Vial Escolano, R.; Lozano Quilis, JA. (2017). The Effect of Balance Training on Postural Control in Patients with Parkinson s Disease Using a Virtual Rehabilitation System. Methods of Information in Medicine. 56(2):138-144. https://doi.org/10.3414/ME16-02-0004S138144562Schwartze, M., & Kotz, S. A. (2016). Regional Interplay for Temporal Processing in Parkinson’s Disease: Possibilities and Challenges. Frontiers in Neurology, 6. doi:10.3389/fneur.2015.00270Nussbaum RL, Ellis CE. Alzheimer’s disease and Parkinson’s disease. N Engl J Med. 2003; 348(14): 1356-1364. Erratum in: N Engl J Med. 2003; 348(25): 2588Pringsheim, T., Jette, N., Frolkis, A., & Steeves, T. D. L. (2014). The prevalence of Parkinson’s disease: A systematic review and meta-analysis. Movement Disorders, 29(13), 1583-1590. doi:10.1002/mds.25945De Lau, L. M., & Breteler, M. M. (2006). Epidemiology of Parkinson’s disease. The Lancet Neurology, 5(6), 525-535. doi:10.1016/s1474-4422(06)70471-9King, L. A., Priest, K. C., Nutt, J., Chen, Y., Chen, Z., Melnick, M., & Horak, F. (2014). Comorbidity and Functional Mobility in Persons with Parkinson Disease. Archives of Physical Medicine and Rehabilitation, 95(11), 2152-2157. doi:10.1016/j.apmr.2014.07.396Von Campenhausen, S., Bornschein, B., Wick, R., Bötzel, K., Sampaio, C., Poewe, W., … Dodel, R. (2005). Prevalence and incidence of Parkinson’s disease in Europe. European Neuropsychopharmacology, 15(4), 473-490. doi:10.1016/j.euroneuro.2005.04.007Muangpaisan, W., Hori, H., & Brayne, C. (2009). Systematic Review of the Prevalence and Incidence of Parkinson’s Disease in Asia. Journal of Epidemiology, 19(6), 281-293. doi:10.2188/jea.je20081034Dorsey, E. R., Constantinescu, R., Thompson, J. P., Biglan, K. M., Holloway, R. G., Kieburtz, K., … Tanner, C. M. (2006). Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030. Neurology, 68(5), 384-386. doi:10.1212/01.wnl.0000247740.47667.03Chaudhuri, K. 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Movement Disorders, 16(3), 507-510. doi:10.1002/mds.1099Nolano, M., Provitera, V., Estraneo, A., Selim, M. M., Caporaso, G., Stancanelli, A., … Santoro, L. (2008). Sensory deficit in Parkinson’s disease: evidence of a cutaneous denervation. Brain, 131(7), 1903-1911. doi:10.1093/brain/awn102Micieli G, Tosi P, Marcheselli S, Cavallini A. Autonomic dysfunction in Parkinson’s disease. Neurol Sci. 2003; 24 Suppl 1: S32-34Salat-Foix, D., & Suchowersky, O. (2012). The management of gastrointestinal symptoms in Parkinson’s disease. Expert Review of Neurotherapeutics, 12(2), 239-248. doi:10.1586/ern.11.192Nombela, C., Bustillo, P. J., Castell, P. F., Sanchez, L., Medina, V., & Herrero, M. T. (2011). Cognitive Rehabilitation in Parkinson’s Disease: Evidence from Neuroimaging. Frontiers in Neurology, 2. doi:10.3389/fneur.2011.00082Poletti, M., De Rosa, A., & Bonuccelli, U. (2012). Affective symptoms and cognitive functions in Parkinson’s disease. Journal of the Neurological Sciences, 317(1-2), 97-102. doi:10.1016/j.jns.2012.02.022Sotgiu, S., Pugliatti, M., Sotgiu, M. A., Fois, M. L., Arru, G., Sanna, A., & Rosati, G. (2005). Seasonal fluctuation of multiple sclerosis births in Sardinia. Journal of Neurology, 253(1), 38-44. doi:10.1007/s00415-005-0917-6FAHN, S. (2006). Description of Parkinson’s Disease as a Clinical Syndrome. Annals of the New York Academy of Sciences, 991(1), 1-14. doi:10.1111/j.1749-6632.2003.tb07458.xCamara, C., Isasi, P., Warwick, K., Ruiz, V., Aziz, T., Stein, J., & Bakštein, E. (2015). Resting tremor classification and detection in Parkinson’s disease patients. Biomedical Signal Processing and Control, 16, 88-97. doi:10.1016/j.bspc.2014.09.006Deuschl, G., Bain, P., & Brin, M. (2008). Consensus Statement of the Movement Disorder Society on Tremor. Movement Disorders, 13(S3), 2-23. doi:10.1002/mds.870131303Massano, J., & Bhatia, K. P. (2012). Clinical Approach to Parkinson’s Disease: Features, Diagnosis, and Principles of Management. Cold Spring Harbor Perspectives in Medicine, 2(6), a008870-a008870. doi:10.1101/cshperspect.a008870Salarian, A., Russmann, H., Wider, C., Burkhard, P. R., Vingerhoets, F. J. G., & Aminian, K. (2007). Quantification of Tremor and Bradykinesia in Parkinson’s Disease Using a Novel Ambulatory Monitoring System. IEEE Transactions on Biomedical Engineering, 54(2), 313-322. doi:10.1109/tbme.2006.886670Dai, H., Zhang, P., & Lueth, T. (2015). Quantitative Assessment of Parkinsonian Tremor Based on an Inertial Measurement Unit. Sensors, 15(10), 25055-25071. doi:10.3390/s151025055Findley, L. J., Gresty, M. A., & Halmagyi, G. M. (1981). Tremor, the cogwheel phenomenon and clonus in Parkinson’s disease. Journal of Neurology, Neurosurgery & Psychiatry, 44(6), 534-546. doi:10.1136/jnnp.44.6.534Berardelli, A. (2001). Pathophysiology of bradykinesia in Parkinson’s disease. Brain, 124(11), 2131-2146. doi:10.1093/brain/124.11.2131Bronnick, K. (2006). Attentional deficits affect activities of daily living in dementia-associated with Parkinson’s disease. Journal of Neurology, Neurosurgery & Psychiatry, 77(10), 1136-1142. doi:10.1136/jnnp.2006.093146Horak FB. Postural orientation and equilibrium: what do we need to know about neural control of balance to prevent falls? Age Ageing. 2006; 35 Suppl 2: ii7-ii11Movement Disorder Society Task Force on Rating Scales for Parkinson’s Disease. The Unified Parkinson’s Disease Rating Scale (UPDRS): status and recommendations. Mov Disord. 2003; 18(7): 738-750. Available from: http://img.medscape.com/fullsize/701/816/58977_UPDRS.pdfGoetz, C. G., Tilley, B. C., Shaftman, S. R., Stebbins, G. T., Fahn, S., Martinez-Martin, P., … LaPelle, N. (2008). Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS): Scale presentation and clinimetric testing results. Movement Disorders, 23(15), 2129-2170. doi:10.1002/mds.22340Dibble, L. E., Hale, T. F., Marcus, R. L., Gerber, J. P., & LaStayo, P. C. (2009). High intensity eccentric resistance training decreases bradykinesia and improves quality of life in persons with Parkinson’s disease: A preliminary study. Parkinsonism & Related Disorders, 15(10), 752-757. doi:10.1016/j.parkreldis.2009.04.009Dibble, L. E., Hale, T. F., Marcus, R. L., Droge, J., Gerber, J. P., & LaStayo, P. C. (2006). High-intensity resistance training amplifies muscle hypertrophy and functional gains in persons with Parkinson’s disease. Movement Disorders, 21(9), 1444-1452. doi:10.1002/mds.20997McIntosh, G. C., Brown, S. H., Rice, R. R., & Thaut, M. H. (1997). Rhythmic auditory-motor facilitation of gait patterns in patients with Parkinson’s disease. Journal of Neurology, Neurosurgery & Psychiatry, 62(1), 22-26. doi:10.1136/jnnp.62.1.22Deane KH, Jones D, Playford ED, Ben-Shlomo Y, Clarke CE. Physiotherapy for patients with Parkinson’s Disease: a comparison of techniques. Cochrane Database Syst Rev. 2001; (3): CD002817Albiol-Pérez S, Lozano-Quilis JA, Gil-Gómez H, Gil-Gómez JA, Llorens R. Virtual rehabilitation system for people with Parkinson disease. 9th Intl Conf. Disability, Virtual Reality & Associated Technologies, Laval, France; 2012Mendes, F. A. dos S., Pompeu, J. E., Lobo, A. M., da Silva, K. G., Oliveira, T. de P., Zomignani, A. P., & Piemonte, M. E. P. (2012). Motor learning, retention and transfer after virtual-reality-based training in Parkinson’s disease – effect of motor and cognitive demands of games: a longitudinal, controlled clinical study. Physiotherapy, 98(3), 217-223. doi:10.1016/j.physio.2012.06.001Saposnik, G., & Levin, M. (2011). Virtual Reality in Stroke Rehabilitation. Stroke, 42(5), 1380-1386. doi:10.1161/strokeaha.110.605451Lozano-Quilis, J.-A., Gil-Gómez, H., Gil-Gómez, J.-A., Albiol-Pérez, S., Palacios-Navarro, G., Fardoun, H. M., & Mashat, A. S. (2014). Virtual Rehabilitation for Multiple Sclerosis Using a Kinect-Based System: Randomized Controlled Trial. JMIR Serious Games, 2(2), e12. doi:10.2196/games.2933Badarny, S., Aharon-Peretz, J., Susel, Z., Habib, G., & Baram, Y. (2014). Virtual Reality Feedback Cues for Improvement of Gait in Patients with Parkinson’s Disease. Tremor and Other Hyperkinetic Movements, 4(0), 225. doi:10.5334/tohm.192Ehgoetz Martens, K. A., Ellard, C. G., & Almeida, Q. J. (2014). Does manipulating the speed of visual flow in virtual reality change distance estimation while walking in Parkinson’s disease? Experimental Brain Research, 233(3), 787-795. doi:10.1007/s00221-014-4154-zAlbiol-Perez, S., Gil-Gomez, J.-A., Llorens, R., Alcaniz, M., & Font, C. C. (2014). The Role of Virtual Motor Rehabilitation: A Quantitative Analysis Between Acute and Chronic Patients With Acquired Brain Injury. IEEE Journal of Biomedical and Health Informatics, 18(1), 391-398. doi:10.1109/jbhi.2013.2272101Forcano-García, M., Muñoz-Tomás, M. T., Manzano-Fernández, P., Solsona-Hernández, S., Mashat, M. A., Gil-Gómez, J. A., & Albiol-Pérez, S. (2015). A Novel Virtual Motor Rehabilitation System for Guillain-Barré Syndrome. Methods of Information in Medicine, 54(02), 127-134. doi:10.3414/me14-02-0002Gil-Gómez, J.-A., Lloréns, R., Alcañiz, M., & Colomer, C. (2011). Effectiveness of a Wii balance board-based system (eBaViR) for balance rehabilitation: a pilot randomized clinical trial in patients with acquired brain injury. Journal of NeuroEngineering and Rehabilitation, 8(1), 30. doi:10.1186/1743-0003-8-30Muñoz Tomás, M. T., Gil Gómez, J. A., Gil Gómez, H., Lozano Quillis, J. A., Albiol-Pérez, S., & Forcano García, M. (2013). Suitability of virtual rehabilitation for elderly: A study of a virtual rehabilitation system using the SEQ. 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D., Jackson, P., Hall, P., & Morgan, J. C. (2013). Nintendo Wii rehabilitation («Wii-hab») provides benefits in Parkinson’s disease. Parkinsonism & Related Disorders, 19(11), 1039-1042. doi:10.1016/j.parkreldis.2013.07.014Holmes, J. D., Jenkins, M. E., Johnson, A. M., Hunt, M. A., & Clark, R. A. (2012). Validity of the Nintendo Wii® balance board for the assessment of standing balance in Parkinson’s disease. Clinical Rehabilitation, 27(4), 361-366. doi:10.1177/0269215512458684Mhatre, P. V., Vilares, I., Stibb, S. M., Albert, M. V., Pickering, L., Marciniak, C. M., … Toledo, S. (2013). Wii Fit Balance Board Playing Improves Balance and Gait in Parkinson Disease. PM&R, 5(9), 769-777. doi:10.1016/j.pmrj.2013.05.019Plotnik, M., Roggen, D., Giladi, N., Hausdorff, J. M., Tröster, G., & Bächlin, M. (2010). A Wearable System to Assist Walking of Parkinson´s Disease Patients. Methods of Information in Medicine, 49(01), 88-95. doi:10.3414/me09-02-0003Rigas, G., Tzallas, A. T., Tsipouras, M. 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The TELE-DD project on treatment nonadherence in the population with type 2 diabetes and comorbid depression

Diabetic patients have increased depression rates, diminished quality of life, and higher death rates due to depression comorbidity or diabetes complications. Treatment adherence (TA) and the maintenance of an adequate and competent self-care are crucial factors to reach optimal glycaemic control and stable quality of life in these patients. In this report, we present the baseline population analyses in phase I of the TELE-DD project, a three-phased population-based study in 23 Health Centres from the Aragonian Health Service Sector II in Zaragoza, Spain. The objectives of the present report are: (1) to determine the point prevalence of T2D and clinical depression comorbidity and treatment nonadherence; (2) to test if HbA1c and LDL-C, as primary DM outcomes, are related to TA in this population; and (3) to test if these DM primary outcomes are associated with TA independently of shared risk factors for DM and depression, and patients’ health behaviours. A population of 7,271 patients with type-2 diabetes and comorbid clinical depression was investigated for inclusion. Individuals with confirmed diagnoses and drug treatment for both illnesses (n = 3340) were included in the current phase I. A point prevalence of 1.9% was found for the T2D-depression comorbidity. The prevalence of patients nonadherent to treatment for these diseases was 35.4%. Multivariate analyses confirmed that lower diabetes duration, increased yearly PCS visits, HbA1c and LDL-C levels were independently related to treatment nonadherence. These findings informed the development of a telephonic monitoring platform for treatment of nonadherence for people with diabetes and comorbid depression and further trial, cost-effectiveness, and prognostic studies (phases II and III)