A head restraint device for vestibular studies

Head restraint device based on vacuum bladder technique for use in vestibular studie

Effects of elevated atmospheric carbon dioxide concentrations on water and acid requirements of soybeans grown in a recirculating hydroponic system

Establishing mass budgets of various crop needs, i.e. water and nutrients, in different environments is essential for the Controlled Ecological Life Support System (CELSS). The effects of CO2 (500 and 1000 umol mol (exp -1)) on water and acid use (for pH control) by soybeans in a recirculating hydroponic system were examined. Plants of cvs. McCall and Pixie were grown for 90 days using the nutrient film technique (NFT) and a nitrate based nutrient solution. System acid use for both CO2 levels peaked near 4 weeks during a phase of rapid vegetative growth, but acid use decreased more rapidly under 500 compared to 1000 umol mol (exp GR) CO2. Total system water use by 500 and 1000 umol mol (exp -1) plants was similar, leaving off at 5 weeks and declining as plants senesced (ca. 9 weeks). However, single leaf transpiration rates were consistently lower at 1000 umol mol (exp -1). The data suggest that high CO2 concentrations increase system acid (and nutrient) use because of increased vegetative growth, which in turn negates the benefit of reduced water use (lower transpiration rates) per unit leaf area

Independent Orbiter Assessment (IOA): Analysis of the DPS subsystem

The results of the Independent Orbiter Assessment (IOA) of the Failure Modes and Effects Analysis/Critical Items List (FMEA/CIL) is presented. The IOA approach features a top-down analysis of the hardware to independently determine failure modes, criticality, and potential critical items. The independent analysis results corresponding to the Orbiter Data Processing System (DPS) hardware are documented. The DPS hardware is required for performing critical functions of data acquisition, data manipulation, data display, and data transfer throughout the Orbiter. Specifically, the DPS hardware consists of the following components: Multiplexer/Demultiplexer (MDM); General Purpose Computer (GPC); Multifunction CRT Display System (MCDS); Data Buses and Data Bus Couplers (DBC); Data Bus Isolation Amplifiers (DBIA); Mass Memory Unit (MMU); and Engine Interface Unit (EIU). The IOA analysis process utilized available DPS hardware drawings and schematics for defining hardware assemblies, components, and hardware items. Each level of hardware was evaluated and analyzed for possible failure modes and effects. Criticality was assigned based upon the severity of the effect for each failure mode. Due to the extensive redundancy built into the DPS the number of critical items are few. Those identified resulted from premature operation and erroneous output of the GPCs

Financial Expertise as an Arms Race

We show that firms intermediating trade have incentives to overinvest in financial expertise. In our model, expertise improves firms’ ability to estimate value when trading a security. Expertise creates asymmetric information, which, under normal circumstances, works to the advantage of the expert as it deters opportunistic bargaining by counterparties. This advantage is neutralized in equilibrium, however, by offsetting investments by competitors. Moreover, when volatility rises the adverse selection created by expertise triggers breakdowns in liquidity, destroying gains to trade and thus the benefits that firms hope to gain through high levels of expertise

Characterization by mercury porosimetry of nonwoven fiber media with deformation

The porosity and pore diameter distribution are important characteristics of nonwoven fiber media. With the advent of electrospinning, the production of mats of nonwoven fibrous materials with fiber diameters in the 0.1-10 mu m range has become more prevalent. The large compliance of these mats makes them susceptible to mechanical deformation under the pressures attained in a typical mercury porosimetry experiment. We report a theoretical analysis of the liquid volume measured during liquid intrusion porosimetry in the presence of deformation of such mats by one of two modes: buckling of the pores or elastic compression of the mat. For electrospun mats of poly(epsilon-caprolactone) with average fiber diameters ranging from 2.49 to 18.0 mu m, we find that buckling is the more relevant mode of deformation, and that it can alter significantly the determination of pore diameter distributions measured by mercury porosimetry.United States. Army Research Office (Institute for Soldier Nanotechnologies, Contract No. DAAD-19-02-D-0002)Massachusetts Institute of Technology (Nicolas G. and Dorothea K. Dumbros Scholarship and Fellowship Fund

Global Energy and Aviation Concerns

Renewable energy sources are usually diffuse and require large facilities. Biofuels work better, are more economical to produce for ground transportation, but sharply increase competition for food croplands. Noble laureate Richard Smalley (deceased-2005) conceptual 20 TWe power generation covers hundreds x hundreds of miles. Combined with Fuller s superconducting power grid system would enable renewable planetary energy. A solar-wind project in Australia will have a 7km diameter collector interfacing with a 1 km tower to extract 200 MW from wind turbines mounted at the base. GE Energy s 3.5MW Wind Turbine is large and placing this in perspective, it is as if one were rotating a Boeing 747-200; the blade diameter is that large. Wind turbines are rapidly gaining popularity in Europe and photovoltaic (PV) is expected to also expand rapidly. It becomes clear that we need (and still have time) to develop new sources of energy. Hf 178 bombarded by X-rays produces Gamma-rays for heating. The reaction stops when the X-rays stop; the half life is about 30 years and seems manageable vs 30 000 years. Water splitting needs to be perused as do ultra fast ultra intense laser applications in terms of fusion and new materials developments including new ways to strip and re-bind hydrogen into fuels. New methods and tools for development are being found in quantum mechanical applications to macro-systems and need to be developed into a set of new tool boxes for development of these new energy sources

Investigating the association of rs2910164 with cancer predisposition in an Irish cohort.

IntroductionMicroRNAs (miRNAs) are small noncoding RNA molecules that exert post-transcriptional effects on gene expression by binding with cis-regulatory regions in target messenger RNA (mRNA). Polymorphisms in genes encoding miRNAs or in miRNA-mRNA binding sites confer deleterious epigenetic effects on cancer risk. miR-146a has a role in inflammation and may have a role as a tumour suppressor. The polymorphism rs2910164 in the MIR146A gene encoding pre-miR-146a has been implicated in several inflammatory pathologies, including cancers of the breast and thyroid, although evidence for the associations has been conflicting in different populations. We aimed to further investigate the association of this variant with these two cancers in an Irish cohort.MethodsThe study group comprised patients with breast cancer (BC), patients with differentiated thyroid cancer (DTC) and unaffected controls. Germline DNA was extracted from blood or from saliva collected using the DNA Genotek Oragene 575 collection kit, using crystallisation precipitation, and genotyped using TaqMan-based PCR. Data were analysed using SPSS, v22.ResultsThe total study group included 1516 participants. This comprised 1386 Irish participants; 724 unaffected individuals (controls), 523 patients with breast cancer (BC), 136 patients with differentiated thyroid cancer (DTC) and three patients with dual primary breast and thyroid cancer. An additional cohort of 130 patients with DTC from the South of France was also genotyped for the variant. The variant was detected with a minor allele frequency (MAF) of 0.19 in controls, 0.22 in BC and 0.27 and 0.26 in DTC cases from Ireland and France, respectively. The variant was not significantly associated with BC (per allele odds ratio = 1.20 (0.98-1.46), P  = 0.07), but was associated with DTC in Irish patients (per allele OR = 1.59 (1.18-2.14), P = 0.002).ConclusionThe rs2910164 variant in MIR146A is significantly associated with DTC, but is not significantly associated with BC in this cohort