Effects of elevated atmospheric carbon dioxide concentrations on water and acid requirements of soybeans grown in a recirculating hydroponic system

Establishing mass budgets of various crop needs, i.e. water and nutrients, in different environments is essential for the Controlled Ecological Life Support System (CELSS). The effects of CO2 (500 and 1000 umol mol (exp -1)) on water and acid use (for pH control) by soybeans in a recirculating hydroponic system were examined. Plants of cvs. McCall and Pixie were grown for 90 days using the nutrient film technique (NFT) and a nitrate based nutrient solution. System acid use for both CO2 levels peaked near 4 weeks during a phase of rapid vegetative growth, but acid use decreased more rapidly under 500 compared to 1000 umol mol (exp GR) CO2. Total system water use by 500 and 1000 umol mol (exp -1) plants was similar, leaving off at 5 weeks and declining as plants senesced (ca. 9 weeks). However, single leaf transpiration rates were consistently lower at 1000 umol mol (exp -1). The data suggest that high CO2 concentrations increase system acid (and nutrient) use because of increased vegetative growth, which in turn negates the benefit of reduced water use (lower transpiration rates) per unit leaf area

Investigating the association of rs2910164 with cancer predisposition in an Irish cohort.

IntroductionMicroRNAs (miRNAs) are small noncoding RNA molecules that exert post-transcriptional effects on gene expression by binding with cis-regulatory regions in target messenger RNA (mRNA). Polymorphisms in genes encoding miRNAs or in miRNA-mRNA binding sites confer deleterious epigenetic effects on cancer risk. miR-146a has a role in inflammation and may have a role as a tumour suppressor. The polymorphism rs2910164 in the MIR146A gene encoding pre-miR-146a has been implicated in several inflammatory pathologies, including cancers of the breast and thyroid, although evidence for the associations has been conflicting in different populations. We aimed to further investigate the association of this variant with these two cancers in an Irish cohort.MethodsThe study group comprised patients with breast cancer (BC), patients with differentiated thyroid cancer (DTC) and unaffected controls. Germline DNA was extracted from blood or from saliva collected using the DNA Genotek Oragene 575 collection kit, using crystallisation precipitation, and genotyped using TaqMan-based PCR. Data were analysed using SPSS, v22.ResultsThe total study group included 1516 participants. This comprised 1386 Irish participants; 724 unaffected individuals (controls), 523 patients with breast cancer (BC), 136 patients with differentiated thyroid cancer (DTC) and three patients with dual primary breast and thyroid cancer. An additional cohort of 130 patients with DTC from the South of France was also genotyped for the variant. The variant was detected with a minor allele frequency (MAF) of 0.19 in controls, 0.22 in BC and 0.27 and 0.26 in DTC cases from Ireland and France, respectively. The variant was not significantly associated with BC (per allele odds ratio = 1.20 (0.98-1.46), P  = 0.07), but was associated with DTC in Irish patients (per allele OR = 1.59 (1.18-2.14), P = 0.002).ConclusionThe rs2910164 variant in MIR146A is significantly associated with DTC, but is not significantly associated with BC in this cohort

Measurement of web tension distribution by point source pulse excitation

A web is a material that is produced as a continuous sheet and stored in wound roll form. Mechanics of web material handling in production, coating or conditioning, and winding operations affect web uniformity and the material stress/strain state, thus affecting roll quality. In an effort to improve all aspects of web handling procedures, much attention has been focused on acquisition and utilization of on-line web handling process information such as web tension. Tension is a quantity basic to web production and processing yet historically has been difficult to measure except in an average sense. Improvements in on-line tension measurement accuracy have foreseeable application to automated tension control systems and winder maintenance used in modern day web production/processing facilities. This paper describes a new means of noncontacting, local web tension measurement through use of a point source pneumatic excitation coupled to signal acquisition and processing schemes. Advantages of this new system include variable web excitation rate, variable system tuning for different applications, high lateral tension distribution resolution, and compact, easily serviceable transducer head assembly. This work was sponsored through the Web Handling Research Center (WHRC), an NSF funded research facility located at Oklahoma State University in Stillwater, Oklahoma.Mechanical and Aerospace Engineerin

Giving Families a Voice for Equitable Healthy Food Access in the Wake of Online Grocery Shopping

Understanding the views of families from low-income backgrounds about inequities in healthy food access and grocery purchase is critical to food access policies. This study explored perspectives of families eligible for the Supplemental Nutrition Assistance Program (SNAP) on healthy food access in physical and online grocery environments. The qualitative design used purposive sampling of 44 primary household food purchasers with children (aged ≤ 8), between November 2020–March 2021, through 11 online focus groups and 5 in-depth interviews. Grounded theory was used to identify community-level perceived inequities, including influences of COVID-19 pandemic, SNAP and online grocery services. The most salient perceived causes of inequitable food access were neighborhood resource deficiencies and public transportation limitations. Rural communities, people with disabilities, older adults, racially and ethnically diverse groups were perceived to be disproportionately impacted by food inequities, which were exacerbated by the pandemic. The ability to use SNAP benefits to buy foods online facilitated healthy food access. Delivery fees and lack of control over food selection were barriers. Barriers to healthy food access aggravated by SNAP included social stigma, inability to acquire cooked meals, and inadequate amount of monthly funds. Findings provide a foundation for policy redesign to promote equitable healthy food systems

Polo-Like Kinase 1 Directs Assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF Complex to Initiate Cleavage Furrow Formation

Polo-like kinase 1 promotes assembly of the contractile ring that divides a cell in two by creating a docking site for the RhoA activator Ect2 on the Cyk-4-containing centralspindlin complex at the midzone of the mitotic spindle

The Prevalence of Children with a History of Sexual Abuse Hospitalized in the Psychiatric Setting

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72548/1/j.1744-6171.1991.tb00489.x.pd

beta-Hydroxy-beta-methylbutyrate free acid reduces markers of exercise-induced muscle damage and improves recovery in resistance-trained men

The purpose of the present study was to determine the effects of short-term supplementation with the free acid form of beta-hydroxy-beta-methylbutyrate (HMB-FA) on indices of muscle damage, protein breakdown, recovery and hormone status following a high-volume resistance training session in trained athletes. A total of twenty resistance-trained males were recruited to participate in a high-volume resistance training session centred on full squats, bench presses and dead lifts. Subjects were randomly assigned to receive either 3 g/d of HMB-FA or a placebo. Immediately before the exercise session and 48 h post-exercise, serum creatine kinase (CK), urinary 3-methylhistadine (3-MH), testosterone, cortisol and perceived recovery status (PRS) scale measurements were taken. The results showed that CK increased to a greater extent in the placebo (329%) than in the HMB-FA group (104%) (P=0.004, d=1.6). There was also a significant change for PRS, which decreased to a greater extent in the placebo (9.1 (SEM 0.4) to 4.6 (SEM 0.5)) than in the HMB-FA group (9.1 (SEM 0.3) to 6.3 (SEM 0.3)) (P=0.005, d = -0.48). Muscle protein breakdown, measured by 3-MH analysis, numerically decreased with HMB-FA supplementation and approached significance (P=0.08, d = 0.12). There were no acute changes in plasma total or free testosterone, cortisol or C-reactive protein. In conclusion, these results suggest that an HMB-FA supplement given to trained athletes before exercise can blunt increases in muscle damage and prevent declines in perceived readiness to train following a high-volume, muscle-damaging resistance-training session