Hemostatic factors and risk of coronary heart disease in general populations: new prospective study and updated meta-analyses

<p>Background: Activation of blood coagulation and fibrinolysis may be associated with increased risk of coronary heart disease. We aimed to assess associations of circulating tissue plasminogen activator (t-PA) antigen, D-dimer and von Willebrand factor (VWF) with coronary heart disease risk.</p> <p>Design: Prospective case-control study, systematic review and meta-analyses.</p> <p>Methods: Measurements were made in 1925 people who had a first-ever nonfatal myocardial infarction or died of coronary heart disease during follow-up (median 19.4 years) and in 3616 controls nested within the prospective population-based Reykjavik Study.</p> <p>Results: Age and sex-adjusted odds ratios for coronary heart disease per 1 standard deviation higher baseline level were 1.25 (1.18, 1.33) for t-PA antigen, 1.01 (0.95, 1.07) for D-dimer and 1.11 (1.05, 1.18) for VWF. After additional adjustment for conventional cardiovascular risk factors, corresponding odds ratios were 1.07 (0.99, 1.14) for t-PA antigen, 1.06 (1.00, 1.13) for D-dimer and 1.08 (1.02, 1.15) for VWF. When combined with the results from previous prospective studies in a random-effects meta-analysis, overall adjusted odds ratios were 1.13 (1.06, 1.21) for t-PA antigen (13 studies, 5494 cases), 1.23 (1.16, 1.32) with D-dimer (18 studies, 6799 cases) and 1.16 (1.10, 1.22) with VWF (15 studies, 6556 cases).</p> <p>Conclusions: Concentrations of t-PA antigen, D-dimer and VWF may be more modestly associated with first-ever CHD events than previously reported. More detailed analysis is required to clarify whether these markers are causal risk factors or simply correlates of coronary heart disease.</p&gt

Landslides in sensitive soils, Tauranga, New Zealand.

In the Tauranga region sensitive soil failures commonly occur after heavy rainfall events, causing considerable infrastructure damage. Several notable landslides include a large failure at Bramley Drive, Omokoroa in 1979, the Ruahihi Canal collapse in 1981, and numerous landslides in May 2005; recently the Bramley Drive scarp was reactivated in 2011. These failures are associated with materials loosely classified as the Pahoia Tephras - a mixture of rhyolitic pyroclastic deposits of approximately 1 Ma. The common link with extreme rainfall events suggests a pore water pressure control on the initiation of these failures. Recent research on the structure of the soils shows a dominance of halloysite clay minerals packed loosely in arrangements with high porosity (51 – 77 %), but with almost entirely micropores. This leads us to conclude that the permeability is very low, and the materials remain continuously wet. The formation of halloysite is encouraged by a wet environment with no episodes of drying, supporting this assumption. A high-resolution CPT trace at Bramley Drive indicates induced pore water pressures rising steadily to a peak at approximately 25 m depth; this depth coincides with the base of the landslide scarp. We infer that elevated pore water pressures develop within this single, thick aquifer, triggering failure through reduced effective stresses. The inactive halloysite clay mineral results in low plasticity indices (13 – 44 %) and hence high liquidity indices (1.2 – 2.4) due to the saturated pore space; remoulding following failure is sudden and dramatic and results in large debris runout distances

The Importance of Heating System Transient Response in Domestic Energy Labelling

European National Calculation Methods (NCM), such as the UK Standard Assessment Procedure (SAP), are used to make standardised and simplified assessments of building energy performance. These NCMs contain simplifications to aid ease of use and comparability of resulting Energy Performance Certificates (EPC). By comparing SAP with a modern, dynamic modelling system, this study quantifies internal temperatures and thereby heating energy consumption. Results show that for the considered test house SAP results correspond closely to a dynamic model using an idealistic heating system, with perfect control and instant responsiveness. However, the introduction of a dynamic, physically realistic gas fired boiler and water based heating system to the model results in a consistent increase in internal temperature (0.5 °C) and energy demand (by ca. 1000 kWh/a). Variation of further parameters within the dynamic model, controls and heat source size, are presented and compared to SAP results and assumptions. The inclusion of more realistic dynamics in building energy modelling for NCMs may provide a better basis for effective decision making with respect to a wide range of heating systems

Remote sensing in Michigan for land resource management

The utilization of NASA earth resource survey technology as an important aid in the solution of current problems in resource management and environmental protection in Michigan is discussed. Remote sensing techniques to aid Michigan government agencies were used to achieve the following results: (1) provide data on Great Lakes beach recession rates to establish shoreline zoning ordinances; (2) supply technical justification for public acquisition of land to establish the St. John's Marshland Recreation Area; (3) establish economical and effective methods for performing a statewide wetlands survey; (4) accomplish a variety of regional resource management actions in the Upper Peninsula; and (5) demonstrate improved soil survey methods. The project disseminated information on remote sensing technology and provided advice and assistance to a number of users in Michigan

Comments on the black hole information problem

String theory provides numerous examples of duality between gravitational theories and unitary gauge theories. To resolve the black hole information paradox in this setting, it is necessary to better understand how unitarity is implemented on the gravity side. We argue that unitarity is restored by nonlocal effects whose initial magnitude is suppressed by the exponential of the Bekenstein-Hawking entropy. Time-slicings for which effective field theory is valid are obtained by demanding the mutual back-reaction of quanta be small. The resulting bounds imply that nonlocal effects do not lead to observable violations of causality or conflict with the equivalence principle for infalling observers, yet implement information retrieval for observers who stay outside the black hole.Comment: 18 pages, 2 figures, revtex, v2 figure added and some improvements to presentatio

Modifying the Einstein Equations off the Constraint Hypersuface

A new technique is presented for modifying the Einstein evolution equations off the constraint hypersurface. With this approach the evolution equations for the constraints can be specified freely. The equations of motion for the gravitational field variables are modified by the addition of terms that are linear and nonlocal in the constraints. These terms are obtained from solutions of the linearized Einstein constraints.Comment: 4 pages, 1 figure, uses REVTe

Nonsingular Black Hole Evaporation and ``Stable'' Remnants

We examine the evaporation of two--dimensional black holes, the classical space--times of which are extended geometries, like for example the two--dimensional section of the extremal Reissner--Nordstrom black hole. We find that the evaporation in two particular models proceeds to a stable end--point. This should represent the generic behavior of a certain class of two--dimensional dilaton--gravity models. There are two distinct regimes depending on whether the back--reaction is weak or strong in a certain sense. When the back--reaction is weak, evaporation proceeds via an adiabatic evolution, whereas for strong back--reaction, the decay proceeds in a somewhat surprising manner. Although information loss is inevitable in these models at the semi--classical level, it is rather benign, in that the information is stored in another asymptotic region.Comment: 23 pages, 6 figures, harvmac and epsf, RU-93-12, PUPT-1399, NSF-ITP-93-5

A theory of quantum black holes: non-perturbative corrections and no-veil conjecture

A common belief is that further quantum corrections near the singularity of a large black hole should not substantially modify the semiclassical picture of black hole evaporation; in particular, the outgoing spectrum of radiation should be very close to the thermal spectrum predicted by Hawking. In this paper we explore a possible counterexample: in the context of dilaton gravity, we find that non-perturbative quantum corrections which are important in strong coupling regions may completely alter the semiclassical picture, to the extent that the presumptive space-like boundary becomes time-like, changing in this way the causal structure of the semiclassical geometry. As a result, only a small fraction of the total energy is radiated outside the fake event horizon; most of the energy comes in fact at later retarded times and there is no information loss problem. Thus we propose that this may constitute a general characteristic of quantum black holes, that is, quantum gravity might be such as to prevent the formation of global event horizons. We argue that this is not unnatural from the viewpoint of quantum mechanics.Comment: 24 pages, 12 figures (not included, available by request), UTTG-22-9

Statistical Origin of Black Hole Entropy in Matrix Theory

The statistical entropy of black holes in M-theory is considered. Assuming Matrix theory is the discretized light-cone quantization of a theory with eleven-dimensional Lorentz invariance, we map the counting problem onto the original Gibbons-Hawking calculation of the thermodynamic entropy.Comment: 9 pages, harvmac, (v2 References added, typo fixed), (v3 Some clarifying comments added.