10,158 research outputs found
Electronic marking and identification techniques to discourage document copying
Modern computer networks make it possible to distribute documents quickly and economically by electronic means rather than by conventional paper means. However, the widespread adoption of electronic distribution of copyrighted material is currently impeded by the ease of illicit copying and dissemination. In this paper we propose techniques that discourage illicit distribution by embedding each document with a unique codeword. Our encoding techniques are indiscernible by readers, yet enable us to identify the sanctioned recipient of a document by examination of a recovered document. We propose three coding methods, describe one in detail, and present experimental results showing that our identification techniques are highly reliable, even after documents have been photocopied
Glyoxal 4-nitrophenylhydrazone : triple helices linked into a three-dimensional channel structure
Peer reviewedPublisher PD
Once more about gauge invariance in \phi\to\gamma\pi0\pi0
It is argued that the realization of gauge invariance condition as a
consequent of cancellation between the \phi\to\gamma f0\to\gamma\pi0\pi0
resonance contribution and a \phi\to\gamma\pi0\pi0 background one, suggested in
Ref. [1], is misleading.Comment: 4 pages, one reference adde
Hydrogen bonding in C-methylated nitroanilines : the three-dimensional framework structure of 2-methyl-4-nitroaniline
Peer reviewedPublisher PD
A triclinic polymorph of benzanilide : disordered molecules form hydrogen-bonded chains
Peer reviewedPublisher PD
A review of cytokine-based pathophysiology of Long COVID symptoms
The Long COVID/Post Acute Sequelae of COVID-19 (PASC) group includes patients with initial mild-to-moderate symptoms during the acute phase of the illness, in whom recovery is prolonged, or new symptoms are developed over months. Here, we propose a description of the pathophysiology of the Long COVID presentation based on inflammatory cytokine cascades and the p38 MAP kinase signaling pathways that regulate cytokine production. In this model, the SARS-CoV-2 viral infection is hypothesized to trigger a dysregulated peripheral immune system activation with subsequent cytokine release. Chronic low-grade inflammation leads to dysregulated brain microglia with an exaggerated release of central cytokines, producing neuroinflammation. Immunothrombosis linked to chronic inflammation with microclot formation leads to decreased tissue perfusion and ischemia. Intermittent fatigue, Post Exertional Malaise (PEM), CNS symptoms with "brain fog," arthralgias, paresthesias, dysautonomia, and GI and ophthalmic problems can consequently arise as result of the elevated peripheral and central cytokines. There are abundant similarities between symptoms in Long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). DNA polymorphisms and viral-induced epigenetic changes to cytokine gene expression may lead to chronic inflammation in Long COVID patients, predisposing some to develop autoimmunity, which may be the gateway to ME/CFS
Chlamydia control activities in Europe: cross-sectional survey
Background: Chlamydia is the most commonly reported bacterial sexually transmitted infection in Europe. The objective of the Screening for Chlamydia in Europe (SCREen) project was to describe current and planned chlamydia control activities in Europe.
Methods: The authors sent a questionnaire asking about different aspects of chlamydia epidemiology and control to public health and clinical experts in each country in 2007. The principles of sexually transmitted infection control were used to develop a typology comprising five categories of chlamydia control activities. Each country was assigned to a category, based on responses to the questionnaire.
Results: Experts in 29 of 33 (88%) invited countries responded. Thirteen of 29 countries (45%) had no current chlamydia control activities. Six countries in this group stated that there were plans to introduce chlamydia screening programmes. There were five countries (17%) with case management guidelines only. Three countries (10%) also recommended case finding amongst partners of diagnosed chlamydia cases or people with another sexually transmitted infection. Six countries (21%) further specified groups of asymptomatic people eligible for opportunistic chlamydia testing. Two countries (7%) reported a chlamydia screening programme. There was no consistent association between the per capita gross domestic product of a country and the intensity of chlamydia control activities (P = 0.816).
Conclusion: A newly developed classification system allowed the breadth of ongoing national chlamydia control activities to be described and categorized. Chlamydia control strategies should ensure that clinical guidelines to optimize chlamydia diagnosis and case management have been implemented before considering the appropriateness of screening programmes
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Helping out: a national survey of volunteering and charitable giving
This report details the main findings of a national survey of volunteering and charitable giving – termed Helping Out – carried out by the National Centre for Social Research (NatCen) in partnership with the Institute for Volunteering Research (IVR) in 2006/07. The study was carried out for the Office of the Third Sector in the Cabinet Office.
The main aims of the study were to examine:
- how and why people give unpaid help to organisations, and what they think of their experiences;
- what stops people from giving help;
- the links between giving time and giving money;
- how, why and how much people give money to charity;
- what stops people from giving money to charity.
There was also interest in estimates of the prevalence of volunteering and charitable giving. However, for a number of reasons (detailed in Chapters 2 and 10), prevalence estimates derived from this study should not be used to look at changes in these measures over time. Other study series are better suited to this purpose.
In terms of volunteering, the study focused on formal help given through groups and organisations rather than informal help (given as an individual, e.g. to family and friends)
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