BIOMASSA E COMPRIMENTO DE RAÍZES FINAS EM POVOAMENTO DE Acacia mearnsii DE WILD. ESTABELECIDO EM ÁREA DEGRADADA POR MINERAÇÃO DE CARVÃO

The coal mining in open pit mining system cause great environmental degradation, mainly of the soil. The revegetação with arboreal species is the best form of recovering these areas. Among the potential species for the degraded areas recovery in the Brazil south, Acacia mearnsii stands out, for fast growth and symbiotic association capacity. The objective of present work was to estimate the biomass and the length of fine roots (≤ 2 mm of diameter) in different soil depths in a four years old Acacia mearnsii stands with 4 m x 1.5 spaced, established in a degraded area by coal mining. The study was carried out in Butiá (RS), in the Copelmi Mineração Ltda company. Four monoliths of 25 cm x 25 cm x 60 cm were sampled and divided into six geometric sections at depths 0-10, 10-20, 20-30, 30-40, 40-50, 50-60 cm and in these same depths soil samples were collected for chemical and density analysis. Roots were separated from the soil by using a set of two sieves (mesh 2 mm and 1 mm) and water jets. The intersection method was used to determine root length. Fine root total biomass and length found for Acacia mearnsii were 6,924 kg ha-1 and 433,441 km ha-1, standing out that 86.78% and 86.59%, respectively, were concentrated in the first 20 cm of soil depth.A mineração de carvão em sistema de lavra a céu aberto ocasiona grande degradação ambiental, principalmente do solo. A revegetação com espécies arbóreas é a melhor forma de recuperar essas áreas. Dentre as espécies potenciais para a recuperação de áreas degradadas no Sul do Brasil, Acacia mearnsii destaca-se, em virtude de seu rápido crescimento e capacidade de associação simbiótica. O presente trabalho teve por objetivo estimar a biomassa e o comprimento de raízes finas (≤ 2 mm de diâmetro), em diferentes profundidades do solo, em povoamento de Acacia mearnsii, com 4 anos de idade e espaçamento 4 x 1,5 m, estabelecido em área degradada pela mineração de carvão. O estudo foi realizado no município de Butiá (RS), na empresa Copelmi Mineração Ltda. Foram amostrados quatro monólitos de 25 x 25 x 60 cm. Os monólitos foram divididos em seis perfis geométricos, nas profundidades de 0-10, 10-20, 20-30, 30-40, 40-50, 50-60 cm. Nessas mesmas profundidades, foram coletadas amostras de solo para análise química e densidade. A separação das raízes do solo foi por meio de um conjunto de duas peneiras (2 e 1 mm de malha) e jatos d’água. Na determinação do comprimento de raízes, foi utilizado o método de intersecção. A biomassa e o comprimento total de raízes finas encontradas para a Acacia mearnsii foram de 6.924 kg ha-1 e 433.441 km ha-1, ressaltando que 86,78% e 86,59% desses valores, respectivamente, estavam concentrados nos primeiros 20 cm de profundidade do solo

Exigência nutricional de mudas de erva-mate (Ilex paraguariensis A. St.-Hil.) à adubação fosfatada.

Experiments were installed in the Forestry Technological Center belonging to Forest Science/CCR/UFSM Department in order to study the nutritional exigency of Ilex paraguariensis A. St.-Hil. seedlings to fertilization of phosphorus doses. Vases with capacity of 2 dm3 were filled out with Red Yellow Argisol soil collected from a superficial layer (0-20 cm), which was homogenized, dried in the air, past in sieve of 5 mm and analyzed  chemically. As additional fertilization, 64 mg kg-1 of N and 38 mg kg-1 K were added the sources were CH4N2O and KCl. The experimental design used was completely randomized with 8 treatments and 6 repetitions, distributed in the following way: T1-control (sole without P addition), T2-90 mg kg-1, T3-180 mg kg-1, T4-270 mg kg-1, T5-360 mg kg-1, T6-450 mg kg-1, T7-540 mg kg-1 and T8-630 mg kg-1 of P, respectively. After 10 months, the following parameters were evaluated: the height of the aerial part, stem diameter, biomass above ground, root biomass and total biomass. The best development of the erva-mate seedlings were observed in the doses from 360 and 450 mg P kg-1. Com o objetivo de estudar a exigência nutricional de mudas de erva-mate (Ilex paraguariensis A. St.-Hil.) à adubação fosfatada, foi instalado um experimento no Centro Tecnológico de Silvicultura pertencente ao Departamento de Ciências Florestais/CCR/UFSM. Vasos com capacidade de 2 dm3 foram preenchidos com 2 kg de solo do tipo Argissolo Vermelho-Amarelo coletado na camada superficial (0-20 cm), o qual foi destorroado, homogeneizado, seco ao ar, passado em peneira de 5 mm e posteriormente analisado quimicamente. Como adubação complementar, foram adicionados 64 mg kg-1 de N e 38 mg kg-1 de K, as fontes utilizadas foram CH4N2O e KCl, respectivamente. O delineamento experimental utilizado foi o inteiramente casualizado com oito tratamentos e seis repetições, distribuídos da seguinte forma: T1-testemunha (solo sem adição de P), T2-90 mg kg-1, T3-180 mg kg-1, T4-270 mg kg-1, T5-360 mg kg-1, T6-450 mg kg-1, T7-540 mg kg-1 e T8-630 mg kg-1 de P respectivamente, a fonte de P foi CaHPO4. Decorridos 10 meses da repicagem foram realizadas as medições das variáveis: altura da parte aérea, diâmetro do colo, biomassa acima do solo, biomassa radicular e biomassa total. O melhor desenvolvimento das mudas de erva-mate foi observado nas doses de 360 e 450 mg kg-1 de P

An updated portrait of monocyte-macrophages in classical Hodgkin lymphoma

Classical Hodgkin lymphoma (cHL) is a unique neoplastic ecosystem characterized by a heterogeneous immune infiltrate surrounding the rare malignant Hodgkin Reed-Sternberg cells. Though less abundant than T-cells, tumor-infiltrating macrophages play a pivotal role in supporting HRS survival through cell-to-cell and paracrine interactions. Traditional immunohistochemistry based upon the M1-M2 dichotomy yielded controversial results about the composition, functional role and prognostic impact of macrophages in cHL. More recent studies exploiting single-cell technologies and image analyses have highlighted the heterogeneity and the peculiar spatial arrangement of the macrophagic infiltrate, with the most immunosuppressive subpopulations lying in close proximity of HRS cells and the most tumor-hostile subsets kept far away from the neoplastic niches. High-throughput analysis of peripheral blood mononuclear cells in cHL patients have also identified a novel, potentially cytotoxic, subpopulation predicting better response to PD-1 blockade. This review examines the phenotypic profile, spatial localization and clinical impact of tumor-infiltrating macrophages and circulating monocytes in cHL, providing an up-do-date portrait of these innate immune cells with possible translational applications

NUTRITIONAL EXIGENCY OF ERVA-MATE ( Ilex paraguariensis A. St.-Hil.) SEEDLINGS TO THE PHOSPHORUS FERTILIZATION

Experiments were installed in the Forestry Technological Center belonging to Forest Science/CCR/UFSM Department in order to study the nutritional exigency of Ilex paraguariensis A. St.-Hil. seedlings to fertilization of phosphorus doses. Vases with capacity of 2 dm3 were filled out with Red Yellow Argisol soil collected from a superficial layer (0-20 cm), which was homogenized, dried in the air, past in sieve of 5 mm and analyzed chemically. As additional fertilization, 64 mg kg-1 of N and 38 mg kg-1 K were added the sources were CH4N2O and KCl. The experimental design used was completely randomized with 8 treatments and 6 repetitions, distributed in the following way: T1-control (sole without P addition), T2-90 mg kg-1, T3-180 mg kg-1, T4-270 mg kg-1, T5-360 mg kg-1, T6-450 mg kg-1, T7-540 mg kg-1 and T8-630 mg kg-1 of P, respectively. After 10 months, the following parameters were evaluated: the height of the aerial part, stem diameter, biomass above ground, root biomass and total biomass. The best development of the erva-mate seedlings were observed in the doses from 360 and 450 mg P kg-1

Case Report: Rapid renal response to venetoclax monotherapy in a CLL patient with secondary membranous glomerulonephritis

Membranous glomerulonephritis (MGN) is a rare extra-hematological autoimmune complication of chronic lymphocytic leukemia (CLL), clinically characterized by nephrotic-range proteinuria and, less frequently, renal failure. Because of the rarity of this condition, there is no standardized treatment. Chlorambucil and fludarabine-based regimens, possibly combined with rituximab, have been historically the most frequent therapeutic approaches, with renal response obtained in about two-third of the patients. However, responses are often transient and partial. Here we describe the first patient with rituximab-refractory, CLL-related MGN successfully treated with the Bcl-2 antagonist venetoclax. Nephrotic syndrome resolved as soon as three months after venetoclax initiation, with no unexpected toxicities. At the last follow-up, 17 months after venetoclax start, renal response persists, with proteinuria below 0.5 g/24 hours. This case suggests that targeted agents, particularly Bcl-2 antagonists, might be suitable options for patients with renal autoimmune disorders arising in the context of CLL

NUTRITIONAL EXIGENCY OF ERVA-MATE ( Ilex paraguariensis A. St.-Hil.) SEEDLINGS TO THE PHOSPHORUS FERTILIZATION

Experiments were installed in the Forestry Technological Center belonging to Forest Science/CCR/UFSM Department in order to study the nutritional exigency of Ilex paraguariensis A. St.-Hil. seedlings to fertilization of phosphorus doses. Vases with capacity of 2 dm3 were filled out with Red Yellow Argisol soil collected from a superficial layer (0-20 cm), which was homogenized, dried in the air, past in sieve of 5 mm and analyzed chemically. As additional fertilization, 64 mg kg-1 of N and 38 mg kg-1 K were added the sources were CH4N2O and KCl. The experimental design used was completely randomized with 8 treatments and 6 repetitions, distributed in the following way: T1-control (sole without P addition), T2-90 mg kg-1, T3-180 mg kg-1, T4-270 mg kg-1, T5-360 mg kg-1, T6-450 mg kg-1, T7-540 mg kg-1 and T8-630 mg kg-1 of P, respectively. After 10 months, the following parameters were evaluated: the height of the aerial part, stem diameter, biomass above ground, root biomass and total biomass. The best development of the erva-mate seedlings were observed in the doses from 360 and 450 mg P kg-1

Computer-aided diagnosis of melanocytic lesions

The clinical diagnosis of melanoma could be difficult for a general practitioner and, in some cases, for dermatologists. To enhance and support the clinical evaluation of pigmented skin lesions a computer-aided diagnosis has been introduced