Effect of Aquatic Immersion on Static Balance

Objective To quantitatively assess measures of static balance and limits of stability (LOS) in an aquatic environment compared to on land. Methods Fifteen healthy, young adults (23 + or - 2 years) performed 90 s static balance trials on land and aquatic immersion at two different depths (greater trochanter, xiphoid process). Measures of 95% ellipse area and center of pressure (CoP) mean velocity were computed from the force data. Additionally, participants completed a visual analog scale (VAS) of perceived stability for each environmental condition. Following the static balance trials, participants performed anterior-posterior and medial-lateral LOS assessments. Results Significant differences in 95% ellipse area and CoP mean velocity were observed for the aquatic environments compared to on land (p \u3c 0.05). VAS data revealed significant differences in perceived balance in an aquatic environment compared to on land (p \u3c 0.05). LOS assessments revealed a significant difference in maximum CoP excursions in an aquatic environment compared to land (p \u3c 0.05). Conclusion When participants performed a quiet double-leg stance task, measures of balance and perceived stability were inferior when the task was performed in water than on land. Additionally, participants achieved greater CoP maximum excursions in the water compared to on land. Although future research is needed to assess factors influencing balance in the water, the added instability in the water is clinically relevant. Results of this study further highlight the importance of considering the inclusion of aquatic training as part of a comprehensive training / rehabilitation program

La géographie linguistique de l’Acadiana

On reconnaît depuis fort longtemps en Louisiane une région culturelle française. Récemment cette aire de forme triangulaire fut désignée « Acadiana ». Loin d'être homogène, Acadiana est extrêmement diversifié. Se servant des données du recensement de 1970, on peut y distinguer quatre types de zones linguistiques françaises : (1) zones de retranchement, (2) zones de solide majorité francophone, (3) zones équilibrées et (4) zones à minorité francophone.A unique French cultural region has long been noted in Louisiana. In recent years this triangular shaped area has received the designation "Acadiana". Far from being homogeneous, Acadiana is extremely diverse. Using French mother tongue population data from the 1970 census one can identify four types of French linguistic zones within Acadiana: (1) exclusive French, (2) solid majority, (3) balanced and (4) minority

A Mixed-Methods Approach to Evaluating the Internal Validity of the Reactive Strength Index

The reactive capacity of the muscle-tendon complex is commonly assessed using the reactive strength index (RSI). Conventionally, the RSI is a ratio of rebound jump height to ground contact time in depth jumping. Several assumptions regarding the linear mechanics acting through the whole-body center of gravity may threaten the internal validity of computation and interpretation of RSI scores. First, it is common for rebound jump height to be predicted from rebound jump flight time. This assumes that the angular positioning of body segments is equivalent at the time instances of rebound jump take-off and landing. Prior literature supports a mixed-methods approach for computing the RSI that is void of this assumption. The mixed-methods approach gives a more valid estimation of rebound jump height. In this approach, rebound jump height is estimated from rebound jump take-off velocity of the whole-body center of mass. This is accomplished by subtracting an estimate of impact velocity, acquired using videography, from change in whole-body center of mass velocity estimated from integrated vertical ground reaction force data. Second, it is often assumed that vertical displacement of the whole-body center of mass during the drop phase of the depth jump is predicted perfectly from the height of the platform used to perform the drop. This assumption may affect the internal validity of comparing RSI scores across individuals and within individuals performing depth jumps from varied heights. The purpose of the present study was to investigate the internal validity of RSI scores computed using the conventional approach and impact velocity variability, which may affect the interpretation of RSI scores. Seventy physically active young adults performed depth jumps from drop heights of 0.51, 0.66, and 0.81 m. RSI was computed using the conventional approach and a mixed-methods approach featuring the use of 2-dimensional videography, body segment parameters, and force platform dynamometry. The two computational methods were compared using linear regression performed on data from each drop height. In addition, a 2 (computational method) by 3 (drop height) Analysis of Variance (ANOVA) was performed to evaluate for main effects and interactions in RSI data. Multiple one sample t-tests were performed to compare estimated and theoretical impact velocities. The ANOVA revealed no main effect or interactions between computational approaches (p = 0.467–0.938). Linear regression revealed moderately strong associations between RSI scores computed using the conventional and mixed-methods approaches (R2 = 0.685–0.741). Moreover, linear regressions revealed that the conventional approach tends to overestimate the mixed methods approach for RSI scores below 1.0 and underestimate the mixed methods approach for RSI scores above 1.0. Lastly, estimated impact velocities were observed to be as much as 13% lower versus theoretical (p \u3c 0.001). Researchers with access to motion capture and force platform technology may consider using a mixed-methods approach for computing the RSI, which likely maximizes the internal validity of scores. In addition, results suggest for practitioners to practice caution when comparing conventional RSI scores across individuals

Effects of Stroboscopic Vision on Depth Jump Motor Control: A Biomechanical Analysis

Researchers commonly use the \u27free-fall\u27 paradigm to investigate motor control during landing impacts, particularly in drop landings and depth jumps (DJ). While recent studies have focused on the impact of vision on landing motor control, previous research fully removed continuous visual input, limiting ecological validity. The aim of this investigation was to evaluate the effects of stroboscopic vision on depth jump (DJ) motor control. Ground reaction forces (GRF) and lower-extremity surface electromyography (EMG) were collected for 20 young adults (11 male; 9 female) performing six depth jumps (0.51 m drop height) in each of two visual conditions (full vision vs. 3 Hz stroboscopic vision). Muscle activation magnitude was estimated from EMG signals using root-mean-square amplitudes (RMS) over specific time intervals (150 ms pre-impact; 30–60 ms, 60–85 ms, and 85–120 ms post-impact). The main effects of and interactions between vision and trial number were assessed using two-way within-subjects repeated measures analyses of variance. Peak GRF was 6.4% greater, on average, for DJs performed with stroboscopic vision compared to full vision (p = 0.042). Tibialis anterior RMS EMG during the 60–85 ms post-impact time interval was 14.1% lower for DJs performed with stroboscopic vision (p = 0.020). Vastus lateralis RMS EMG during the 85–120 ms post-impact time interval was 11.8% lower for DJs performed with stroboscopic vision (p = 0.017). Stroboscopic vision altered DJ landing mechanics and lower-extremity muscle activation. The observed increase in peak GRF and reduction in RMS EMG of the tibialis anterior and vastus lateralis post-landing may signify a higher magnitude of lower-extremity musculotendinous stiffness developed pre-landing. The results indicate measurable sensorimotor disruption for DJs performed with stroboscopic vision, warranting further research and supporting the potential use of stroboscopic vision as a sensorimotor training aid in exercise and rehabilitation. Stroboscopic vision could induce beneficial adaptations in multisensory integration, applicable to restoring sensorimotor function after injury and preventing injuries in populations experiencing landing impacts at night (e.g., military personnel)

A Comprehensive Examination of Age-Related Lower Limb Muscle Function Asymmetries Across a Variety of Muscle Action Types

Previous research has found that lower limb muscle asymmetries increase with age and are linked to fall and injury risks. However, past studies lack a wide variety of muscle function modes and measures as well as comparison to a comparable younger age group. The purpose of this study was to examine age-related lower limb muscle function asymmetries across a variety of muscle action types and velocities in young and old adults. Lower limb balance, strength, power, and velocity were evaluated with concentric, isometric, isotonic, and eccentric muscle actions during a single-leg stance test and on single- and multi-joint dynamometers in 29 young (age = 21.45 ± 3.02) and 23 old (age = 77.00 ± 4.60) recreationally active men and women. Most (15 of 17) variables showed no statistical (p \u3e 0.05) or functional (10% threshold) limb asymmetry for either age group. There was a significant main effect (p = 0.046; collapsed across groups) found for asymmetry (dominant \u3e non-dominant) for the isotonic peak velocity variable. There was a significant (p = 0.010) group × limb interaction for single-joint concentric peak power produced at a slow (60 deg/s) velocity due to the non-dominant limb of the young group being 12.2% greater than the dominant limb (p \u3c 0.001), whereas the old group was not asymmetrical (p = 0.965). The findings of this investigation indicate there is largely no age-related asymmetry of the lower limbs across a range of muscle function-related variables and modes, with a couple of notable exceptions. Also, the significant asymmetries for the isotonic peak velocity variable perhaps show the sensitivity of this uncommonly used measure in detecting minimally present muscle function imbalances

Lower Limb Muscle Activation in Young Adults Walking in Water and on Land

Previous research has shown that exercise interventions requiring increased activation of the tibialis anterior (TA), the primary ankle dorsiflexor, can improve walking performance in individuals with foot drop. Correspondingly, heightened drag forces experienced during walking performed in water may augment TA activation during the swing phase of gait, potentially leading to improved walking gait on land. Therefore, this study aimed to compare surface electromyographic (sEMG) activation in the TA and medial gastrocnemius (GM) during gait performed in water versus on land. Thirty-eight healthy, recreationally active young adults, comprising 18 females and 20 males, participated in the study. Each participant completed 2 min walking trials under five conditions: land 2.5 mph, land 3.5 mph, water 2.5 mph, water 3.5 mph, and water 3.5 mph with added jet resistance. Stride kinematics were collected using 2-dimensional underwater motion capture. TA and GM, muscle activation magnitudes, were quantified using sEMG root-mean-square (RMS) amplitudes for both the swing and stance phases of walking. Additionally, TA and GM co-activation (Co-A) indices were estimated. Two-way within-subjects repeated measures analyses of variance were used to evaluate the main effects of and interactions between the environment and walking speed. Additionally, paired sample t-tests were conducted as a secondary analysis to investigate differences between walking in water at 3.5 mph with and without added jet resistance. Main effects and interactions were observed across various stride kinematics and sEMG measures. Notably, TA sEMG RMS during the swing phase of walking gait performed at 2.5 mph was 15% greater in water than on land (p \u3c 0.001). This effect increased when walking gait was performed at 3.5 mph (94%; p \u3c 0.001) and when jet resistance was added to the 3.5 mph condition (52%; p \u3c 0.001). Furthermore, TA Co-A was increased during the stance phase of gait in water compared to on land (p \u3c 0.001), while GM Co-A was reduced during the swing phase (p \u3c 0.001). The findings of this study offer compelling evidence supporting the efficacy of aquatic treadmill walking as a potential treatment for individuals suffering from foot drop. However, further research is needed to evaluate whether a causal relationship exists between heightened TA activation observed during aquatic treadmill walking and improvements in voluntary dorsiflexion during gait

The gene product Murr1 restricts HIV-1 replication in resting CD4(+) lymphocytes

Although human immunodeficiency virus-1 (HIV-1) infects quiescent and proliferating CD4(+) lymphocytes, the virus replicates poorly in resting T cells(1-6). Factors that block viral replication in these cells might help to prolong the asymptomatic phase of HIV infection(7); however, the molecular mechanisms that control this process are not fully understood. Here we show that Murr1, a gene product known previously for its involvement in copper regulation(8,9), inhibits HIV-1 growth in unstimulated CD4(+) T cells. This inhibition was mediated in part through its ability to inhibit basal and cytokine-stimulated nuclear factor (NF)-kappaB activity. Knockdown of Murr1 increased NF-kappaB activity and decreased IkappaB-alpha concentrations by facilitating phospho-IkappaB-alpha degradation by the proteasome. Murr1 was detected in CD4(+) T cells, and RNA-mediated interference of Murr1 in primary resting CD4(+) lymphocytes increased HIV-1 replication. Through its effects on the proteasome, Murr1 acts as a genetic restriction factor that inhibits HIV-1 replication in lymphocytes, which could contribute to the regulation of asymptomatic HIV infection and the progression of AIDS.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/62709/1/nature02171.pd

Embryo movement is more frequent in avian brood parasites than birds with parental reproductive strategies.

Funder: Tanzanian Commission for Science and TechnologyFunder: Tanzania Wildlife Research InstituteFunder: NERCFunder: National Science FoundationFunder: Ministry of EducationFunder: German Academic Exchange ServiceFunder: University of Cape TownFunder: Max-Planck-GesellschaftMovement of the embryo is essential for musculoskeletal development in vertebrates, yet little is known about whether, and why, species vary. Avian brood parasites exhibit feats of strength in early life as adaptations to exploit the hosts that rear them. We hypothesized that an increase in embryonic movement could allow brood parasites to develop the required musculature for these demands. We measured embryo movement across incubation for multiple brood-parasitic and non-parasitic bird species. Using a phylogenetically controlled analysis, we found that brood parasites exhibited significantly increased muscular movement during incubation compared to non-parasites. This suggests that increased embryo movement may facilitate the development of the stronger musculoskeletal system required for the demanding tasks undertaken by young brood parasites