Pisces, Anguilliformes, Moringuidae, Moringua edwardsi (Jordan and Bollman, 1889): first record in Atol das Rocas, northeastern Brazil

Moringua edwardsi is recorded for the first time at Atol das Rocas, northeastern Brazil. Previous records of the species were located in the western Atlantic Ocean, from Florida to southeastern Brazil, but with many gaps between these regions. A single specimen was collected in Atol das Rocas in July 2007 and it is deposited in the Dias da Rocha Ichthyological Collection. The new record of M. edwardsi fills a geographic distribution gap of this species and complements the inventory of fish species inhabiting one of the most unique marine protected areas in the world

Transtornos de personalidade em pacientes com fobia social

The aim of this study was to investigate if other comorbid personality disorders, other than avoidant personality disorder, occur among social phobics. Twenty-two patients with a social phobia diagnosis according to DSM-III-R criteria were evaluated by using the Minnesota Multiphasic Personality Inventory (MMPI), the Structured Interview for DSM-III-R Personality Disorders (SIDP-R) and the Present State Examination (PSE). Fourteen patients (64%) of the sample received at least one personality disorder diagnosis - all of them received avoidant personality disorder diagnosis. One half of personality disordered patients showed two or more personality disorders. Paranoid personality disorder was diagnosed in six patients (27%). Ten patients (46%) evaluated with MMPI had a pathological score in the Paranoia (Pa) scale. Other pathological personality traits were also present in Depression (D), Hysteria (Hy) and Introversion-Extroversion (Si) scales of MMPI. PSE no delusional ideas of reference (IR) occurred in nineteen patients. Paranoid personality disorder was diagnosed in a higher frequency in this study than in most of the other studies, which analyzed social phobics. This appears to have occurred because of not very specific diagnostic criteria overlapping as well as self-reference and paranoid personality traits, such as hypersensitivity and concern about other peoples opinions.O objetivo deste estudo foi investigar se outros transtornos de personalidade, além do transtorno de personalidade esquiva, ocorrem entre fóbicos sociais. Vinte e dois pacientes com diagnóstico de fobia social de acordo com os critérios do DSM-III-R foram avaliados através do Inventário Multifásico Minnesota de Personalidade (MMPI), da Entrevista Estruturada para Distúrbios de Personalidade do DSM-III-R (SIDP-R) e do Exame do Estado Psíquico (PSE). Catorze pacientes (64%) da amostra receberam pelo menos um diagnóstico de transtorno de personalidade - todos estes receberam o diagnóstico de transtorno de personalidade esquiva. Metade dos pacientes que recebeu o diagnóstico de transtornos de personalidade apresentou dois ou mais transtornos de personalidade. O transtorno de personalidade paranóide foi diagnosticado em seis pacientes (27%). Dez pacientes (46%), avaliados através do MMPI, apresentaram escore patológico na escala paranóia (Pa). Outros traços patológicos de personalidade foram observados nas escalas depressão (D), histeria (Hy) e introversão-extroversão (Si) do MMPI. Idéias de referência não-delirantes (IR) do PSE ocorreram em 19 pacientes. O transtorno de personalidade paranóide foi diagnosticado com freqüência maior neste estudo do que na maioria dos estudos realizados com fóbicos sociais. Isso parece ter ocorrido por sobreposição de critérios diagnósticos pouco específicos e também por auto-referência e traços paranóides de personalidade, como hipersensibilidade e preocupação com a opinião alheia

Dermatan sulfate in tunicate phylogeny: Order-specific sulfation pattern and the effect of [→4IdoA(2-Sulfate)β-1→3GalNAc(4-Sulfate)β-1→] motifs in dermatan sulfate on heparin cofactor II activity

After the publication of the work entitled "Dermatan sulfate in tunicate phylogeny: Order-specific sulfation pattern and the effect of [→4IdoA(2-Sulfate)β-1→3GalNAc(4-Sulfate)β-1→] motifs in dermatan sulfate on heparin cofactor II activity", by Kozlowski et al., BMC Biochemistry 2011, 12:29, we found that the legends to Figures 2 to 5 contain serious mistakes that compromise the comprehension of the work. This correction article contains the correct text of the legends to Figures 2 to 5

Structure Elucidation and Anticancer Activity of 7-Oxostaurosporine Derivatives from the Brazilian Endemic Tunicate Eudistoma vannamei

The present study reports the identification of two new staurosporine derivatives, 2-hydroxy-7-oxostaurosporine (1) and 3-hydroxy-7-oxostaurosporine (2), obtained from mid-polar fractions of an aqueous methanol extract of the tunicate Eudistoma vannamei, endemic to the northeast coast of Brazil. The mixture of 1 and 2 displayed IC50 values in the nM range and was up to 14 times more cytotoxic than staurosporine across a panel of tumor cell lines, as evaluated using the MTT assay.CNPqCAPESInCBFAPES

Metabolomic Fingerprinting of Salinispora From Atlantic Oceanic Islands

Salinispora (Micromonosporaceae) is an obligate marine bacterium genus consisting of three species that share over 99% 16S rRNA identity. The genome and biosynthetic pathways of the members of this genus have been widely investigated due to their production of species-specific metabolites. However, despite the species’ high genetic similarity, site-specific secondary metabolic gene clusters have been found in Salinispora strains collected at different locations. Therefore, exploring the metabolic expression of Salinispora recovered from different sites may furnish insights into their environmental adaptation or their chemical communication and, further, may lead to the discovery of new natural products. We describe the first occurrence of Salinispora strains in sediments from the Saint Peter and Saint Paul Archipelago (a collection of islets in Brazil) in the Atlantic Ocean, and we investigate the metabolic profiles of these strains by employing mass-spectrometry-based metabolomic approaches, including molecular networking from the Global Natural Products Social Molecular Networking platform. Furthermore, we analyze data from Salinispora strains recovered from sediments from the Madeira Archipelago (Portugal, Macaronesia) in order to provide a wider metabolomic investigation of Salinispora strains from the Atlantic Oceanic islands. Overall, our study evidences a broader geographic influence on the secondary metabolism of Salinispora than was previously proposed. Still, some biosynthetic gene clusters, such as those corresponding to typical chemical signatures of S. arenicola, like saliniketals and rifamycins, are highly conserved among the assessed strains