2,604 research outputs found

    Chromosomal Instability in Aneuploid Cells

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    Mean curvature flow in a Ricci flow background

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    Following work of Ecker, we consider a weighted Gibbons-Hawking-York functional on a Riemannian manifold-with-boundary. We compute its variational properties and its time derivative under Perelman's modified Ricci flow. The answer has a boundary term which involves an extension of Hamilton's Harnack expression for the mean curvature flow in Euclidean space. We also derive the evolution equations for the second fundamental form and the mean curvature, under a mean curvature flow in a Ricci flow background. In the case of a gradient Ricci soliton background, we discuss mean curvature solitons and Huisken monotonicity.Comment: final versio

    Space shuttle launch vehicle performance trajectory, exchange ratios, and dispersion analysis

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    A baseline space shuttle performance trajectory for Mission 3A launched from WTR has been generated. Design constraints of maximum dynamic pressure, longitudinal acceleration, and delivered payload were satisfied. Payload exchange ratios are presented with explanation on use. Design envelopes of dynamic pressure, SRB staging point, aerodynamic heating and flight performance reserves are calculated and included

    Fermi-LAT Observations of the 2014 May-July outburst from 3C 454.3

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    A prominent outburst of the flat spectrum radio quasar 3C~454.3 was observed in 2014 June with the \emph{Fermi} Large Area Telescope. This outburst was characterized by a three-stage light-curve pattern---plateau, flare and post-flare---that occurred from 2014 May to July, in a similar pattern as observed during the exceptional outburst in 2010 November. The highest flux of the outburst reported in this paper occurred during 2014 June 7--29, showing a multiple-peak structure in the light-curves. The average flux in these 22 days was found to be F[E>100 MeV]=(7.2±0.2)×10−6F[E > 100~\mathrm{MeV}] = (7.2 \pm 0.2) \times 10^{-6}~ph~cm−2^{-2}~s−1^{-1}, with a spectral index, for a simple power law, of Γ=2.04±0.01\Gamma = 2.04 \pm 0.01. That made this outburst the first γ\gamma-ray high state of 3C~454.3 ever to be detected by \emph{Fermi} with such a hard spectrum over several days. The highest flux was recorded on 2014 June 15, in a 3 hr bin, at MJD 56823.5625, at a level of F[E>100 MeV]=(17.6±1.9)×10−6F[E > 100~\mathrm{MeV}] = (17.6 \pm 1.9) \times 10^{-6}~ph~cm−2^{-2}~s−1^{-1}. The rise time of one of the short subflares was found to be Tr=1200±700T_r= 1200 \pm 700~s at MJD = 56827, when the flux increased from 4 to 12 ×10−6\times 10^{-6}~ph~cm−2^{-2}~s−1^{-1}. Several photons above 20 GeV were collected during this outburst, including one at 45 GeV on MJD 56827, constraining the γ\gamma-ray emission region to be located close to the outer boundary of the broad-line region, leading to fast flux variability.Comment: Accepted for publication in {\sc the astrophysical journal}: 2016 July 12}; 15 pages, 7 figures, 6 table

    Analytic Torsion on Hyperbolic Manifolds and the Semiclassical Approximation for Chern-Simons Theory

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    The invariant integration method for Chern-Simons theory for gauge group SU(2) and manifold \Gamma\H^3 is verified in the semiclassical approximation. The semiclassical limit for the partition function associated with a connected sum of hyperbolic 3-manifolds is presented. We discuss briefly L^2 - analytical and topological torsions of a manifold with boundary.Comment: 12 pages, LaTeX fil

    Do Campaign Donations Alter How Politicians Vote?

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    Journal Club: Glymphatic System in Neurodegenerative Diseases

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    Neurodegenerative diseases such as Alzheimer\u27s Disease impact a multitude of individuals worldwide. The neural Glymphatic system is a relatively newly discovered cellular transport pathway within the brain that has been implicated in neurodegenerative diseases. This article serves to provide a journal club review of current literature on the Glymphatic system to raise awareness of this system and its potential for future treatment and prevention of neurodegenerative conditions

    Retardation of Particle Evaporation from Excited Nuclear Systems Due to Thermal Expansion

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    Particle evaporation rates from excited nuclear systems at equilibrium matter density are studied within the Harmonic-Interaction Fermi Gas Model (HIFGM) combined with Weisskopf's detailed balance approach. It is found that thermal expansion of a hot nucleus, as described quantitatively by HIFGM, leads to a significant retardation of particle emission, greatly extending the validity of Weisskopf's approach. The decay of such highly excited nuclei is strongly influenced by surface instabilities

    Prey localization in spider orb webs using modal vibration analysis

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    Spider webs are finely tuned multifunctional structures, widely studied for their prey capture functionalities such as impact strength and stickiness. However, they are also sophisticated sensing tools that enable the spider to precisely determine the location of impact and capture the prey before it escapes. In this paper, we suggest a new mechanism for this detection process, based on potential modal analysis capabilities of the spider, using its legs as distinct distributed point sensors. To do this, we consider a numerical model of the web structure, including asymmetry in the design, prestress, and geometrical nonlinearity effects. We show how vibration signals deriving from impacts can be decomposed into web eigenmode components, through which the spider can efficiently trace the source location. Based on this numerical analysis, we discuss the role of the web structure, asymmetry, and prestress in the imaging mechanism, confirming the role of the latter in tuning the web response to achieve an efficient prey detection instrument. The results can be relevant for efficient distributed impact sensing applications
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