Dalitz decays DsJ(∗)→Ds(∗)ℓ+ℓ−D_{sJ}^{(*)} \to D_s^{(*)} \ell^+ \ell^-

The Dalitz decays of the positive parity $D_{sJ}^{(*)}$ charmed mesons, $D_{sJ}^{(*)} \to D_s^{(*)} \ell^+ \ell^-$ with $J=0,1,2$ and $\ell=e, \mu$, are important processes to investigate the nature of the $D_{sJ}^{(*)}$ states. We analyze the full set of decays, considering the four lightest $D_{sJ}^{(*)}$ mesons as belonging to the heavy quark spin doublets $\displaystyle s_\ell^P=\frac{1}{2}^+$ and $\displaystyle \frac{3}{2}^+$, with $s_\ell^P$ the spin-parity of the light degrees of freedom in mesons. The description implies relations among the observables in various modes. We study the decay distributions in the dilepton invariant mass squared and the distributions in the angle between the charged lepton momentum and the momentum of the produced meson, which are expressed in terms of universal form factors and of effective strong couplings. Such measurements are feasible at the present facilities.Comment: LaTeX, 23 pages, 6 figures. Version to appear on PR

Flavour anomalies, correlations, hadronic uncertainties, and all that

We present a short overview of the so-called flavour anomalies, discussing their significance and the connections with QCD issues discussed at the HADRON 2023 conference.Comment: LaTeX, 6 pages + references, 3 figures. Plenary talk at HADRON 2023, Genova 5-9 June 2023. To appear in the proceeding

Effect of rearing system (free-range vs cage) on gut and muscle histomorphology and microbial loads of Italian White breed rabbits

Objective The growing consumers’ interest on animal welfare has raised the request of products obtained by alternative rearing systems. The present study was conducted to assess the influence of housing system on gut and muscle morphology and on microbial load in rabbits reared under free-range (FR) and cage system (CS). Methods A total of forty weaned (35 days of age) male Italian White breed rabbits were allotted according to the rearing system, and at 91 days of age were randomly selected and slaughtered for the morphological evaluation of tissue from duodenum and longissimus lumborum. Morphometric analysis of the villus height, villus width, crypt depth, villus height/crypt depth ratio, and villus surface was performed. The microbial loads on hind muscle was determined by total mesophilic aerobic count (TMAC), Escherichia coli and Enterobacteriaceae; whereas, total anaerobic bacteria count (TABC) and TMAC, E. coli and Enterobacteriaceae was determined on caecal content. Results Rearing system did not interfere with the duodenum and muscle histomorphology in both rabbit groups. Similarly, microbial load of caecal content showed no significant differences on the TABC and TMAC. Conversely, significant difference was found for E. coli strains in caecal content, with the lower counts in FR compared to CS rabbits (p<0.01). Microbiological assay of muscle revealed significant lower TMAC in FR vs CS rabbits (p< 0.05). All rabbit meat samples were negative for E. Coli and Enterobacteriaceae. Conclusion Free-range could be considered a possible alternative and sustainable rearing system in rabbits to preserve gut environment and muscle quality

Holographic Study of the

The holographic approach is applied to study the chaotic behaviour of a strongly coupled QQ¯QQ¯ pair in general thermal background. We consider two different backgrounds, one with finite temperature and baryon density, and one with finite temperature and constant magnetic field along a fixed direction. The results allow us to understand the dependence of the chaotic dynamics on the background, to test the universal bound on chaos conjectured by Maldacena, Shenker and Standford (MSS)

Synthesis, Characterization, and in Vitro Evaluation of a New TSPO-Selective Bifunctional Chelate Ligand

The 18-kDa translocator protein (TSPO) is overexpressed in many types of cancers and is also abundant in activated microglial cells occurring in inflammatory neurodegenerative diseases. Thus, TSPO has become an extremely attractive subcellular target not only for imaging disease states overexpressing this protein, but also for a selective mitochondrial drug delivery. In this work we report the synthesis, the characterization, and the in vitro evaluation of a new TSPO-selective ligand, 2-(8-(2-(bis­(pyridin-2-yl)­methyl)­amino)­acetamido)-2-(4-chlorophenyl)<i>H</i>-imidazo­[1,2-<i>a</i>]­pyridin-3-yl)-<i>N</i>,<i>N</i>-dipropylacetamide (<b>CB256</b>), which fulfils the requirements for a bifunctional chelate approach. The goal was to provide a new TSPO ligand that could be used further to prepare coordination complexes of a metallo drug to be used in diagnosis and therapy. However, the ligand itself proved to be a potent tumor cell growth inhibitor and DNA double-strand breaker

Pain management policies and practices in pediatric emergency care: a nationwide survey of Italian hospitals

Pain experienced by children in emergency departments (EDs) is often poorly assessed and treated. Although local protocols and strategies are important to ensure appropriate staff behaviours, few studies have focussed on pain management policies at hospital or department level. This study aimed at describing the policies and reported practices of pain assessment and treatment in a national sample of Italian pediatric EDs, and identifying the assocoated structural and organisational factors

E-consensus on telemedicine in proctology: A RAND/UCLA-modified study

Background: Coronavirus disease 2019 is revolutionizing healthcare delivery. The aim of this study was to reach a consensus among experts as to the possible applications of telemedicine in the proctologic field. Methods: A group of 55 clinical practice recommendations was developed by a clinical guidance group based on coalescence of evidence and expert opinion. The Telemedicine in Proctology Italian Working Group included 47 Italian Society of Colorectal Surgery nominated experts evaluating the appropriateness of each clinical practice recommendations based on published RAND/UCLA methodology in 2 rounds. Results: Stakeholder median age was 53 years (interquartile range limits 40-60), and 38 (81%) were men. Nine (19%) panelists reported no experience with telemedicine before the pandemic. Agreement was obtained on a minimum of 3 to 5 years of practice in the proctologic field before starting teleconsultations, which should be regularly paid, with advice and prescriptions incorporated into a formal report sent to the patient by e-mail along with a receipt. Of the panelists, 35 of 47 (74%) agreed that teleconsultation carries the risk of misdiagnosis of cancer, thus recommending an in-person assessment before scheduling any surgery. Fifteen additional clinical practice recommendations were re-elaborated in the second round and assessed by 44 of 47 (93.6%) panelists. The application of telemedicine for the diagnosis of common proctologic conditions (eg, hemorrhoidal disease, anal abscess and fistula, anal condylomas, and anal fissure) and functional pelvic floor disorders was generally considered inappropriate. Teleconsultation was instead deemed appropriate for the diagnosis and management of pilonidal disease. Conclusion: This e-consensus revealed the boundaries of telemedicine in Italy. Standardization of infrastructures, logistics, and legality remain to be better elucidated