Development and Longevity: Cellular and Molecular Determinants - A Mini-Review

Across species, development and longevity are tightly linked. We discuss the relevant literature and suggest that the root for this stringent relationship is the rate of development. The basis for the relationship between rate of development and longevity lies in adaptations that have occurred through evolution at multiple levels of biological complexity: organism, organ, cellular, and molecular. Thus, the analysis of the relationship is of interest for multiple fields of biology

CONSTRUCTAL THEORY APPLIED TO THE GEOMETRIC OPTIMIZATION OF ELLIPTICAL CAVITIES INTO A SOLID CONDUCTING WALL

This work reports, according to Bejan’s Constructal theory, the geometric optimization of an elliptical cavity that intrudes into a solid conducting wall. The objective is to minimize the global thermal resistance between the solid and the cavity. There is uniform heat generation on the solid wall. The cavity is optimized for two sets of thermal conditions: isothermal cavity and cavity bathed by a steady stream of fluid. The solid conducting wall is isolated on the external perimeter. The total volume and the elliptical cavity volume are fixed while the geometry of the cavity is free to vary. The results show that the optimized geometrical shapes are relatively robust, i.e., insensitive to changes in some of the design parameters: the cavity shape is optimal when penetrates the conducting wall almost completely

Herd structure in the bovine Calvana breed

Farm structure is one of the principle components that influence profit, sustainability and survival of a herd, especially in endangered breeds. The sustainability of these herds is based on the capability to take advantage of specific niches of the market, of specific label or organic certification or "designation of geographical indications or origin for agricultural products"

Factors influencing the first thousand days of life

The first 1,000 days is a vulnerable phase in which parents, institutions and health professionals should create early interventions for the proper development and promotion of good health

Preliminary Real-World Evaluation of an Intervention for Parents of Adolescents: The Open Door Approach to Parenting Teenagers (APT)

Most parenting interventions report high dropout rates for parents who exhibit clinically high levels of stress and/or are parents of adolescents with severe emotional and/or behavioral difficulties. The objective of this preliminary study was to evaluate the feasibility and real-world effectiveness of the Open Door Approach to Parenting Teenagers (APT), a six-session individually delivered face-to-face intervention for typically hard to engage parents of 11 to 21-year-olds. A one-group, pre-post evaluation design was adopted due to the naturalistic clinic-based setting of the study. Participants were 279 parents reporting clinical levels of stress relating to parenting an adolescent. Parents receiving the APT intervention demonstrated lower dropout rates than other parenting programs and reported high scores across several items relating to service satisfaction. The APT intervention was associated with significant reductions in parental stress and improvements in parent-adolescent relationships immediately post-intervention. Findings suggest that parents found the APT intervention acceptable and beneficial, and further suggest that the intervention is feasible and effective in retaining hard to engage parents. Moreover, preliminary findings suggest that the APT intervention is a promising intervention that may support parents who fail to engage in group programs. However, further research is required to establish the efficacy of the intervention

Analytical investigation of the dynamics of tethered constellations in Earth orbit, phase 2

The g-tuning maneuvers of a 3-mass, vertical tethered system are considered. In particular, the case of reaching a zero-g acceleration level on board the middle mass from a non-zero initial condition is analyzed. A control law that provides a satisfactory transient response is derived. The constellation dynamics in the case of the middle mass travelling from one tether tip to the other is also investigated. Instabilities that take place at the end of the maneuver are analyzed and accommodated by devising suitable damping algorithms

FIRI - a Far-Infrared Interferometer

Half of the energy ever emitted by stars and accreting objects comes to us in the FIR waveband and has yet to be properly explored. We propose a powerful Far-InfraRed Interferometer mission, FIRI, to carry out high-resolution imaging spectroscopy in the FIR. This key observational capability is essential to reveal how gas and dust evolve into stars and planets, how the first luminous objects in the Universe ignited, how galaxies formed, and when super-massive black holes grew. FIRI will disentangle the cosmic histories of star formation and accretion onto black holes and will trace the assembly and evolution of quiescent galaxies like our Milky Way. Perhaps most importantly, FIRI will observe all stages of planetary system formation and recognise Earth-like planets that may harbour life, via its ability to image the dust structures in planetary systems. It will thus address directly questions fundamental to our understanding of how the Universe has developed and evolved - the very questions posed by ESA's Cosmic Vision.Comment: Proposal developed by a large team of astronomers from Europe, USA and Canada and submitted to the European Space Agency as part of "Cosmic Vision 2015-2025

Durability of different initial regimens in HIV-infected patients starting antiretroviral therapy with CD4+ counts <200 cells/mm³ and HIV-RNA >5 log₁₀ copies/mL

OBJECTIVES: Our aim was to investigate the durability of different initial regimens in patients starting ART with CD4+ counts 5 log10 copies/mL. METHODS: This was a retrospective study of HIV-infected patients prospectively followed in the ICONA cohort. Those who started ART with boosted protease inhibitors (bPIs), NNRTIs or integrase strand transfer inhibitors (InSTIs), with CD4+ 5 log10 copies/mL, were included. The primary endpoint was treatment failure (TF), a composite endpoint defined as virological failure (VF, first of two consecutive HIV-RNA >50 copies/mL after 6 months of treatment), discontinuation of class of the anchor drug or death. Independent associations were investigated by Poisson regression analysis in a model including age, gender, mode of HIV transmission, CDC stage, HCV and HBV co-infection, pre-treatment HIV-RNA, CD4+ count and CD4+/CD8+ ratio, ongoing opportunistic disease, fibrosis FIB-4 index, estimated glomerular filtration rate, haemoglobin, platelets, neutrophils, calendar year of ART initiation, anchor drug class (treatment group) and nucleos(t)ide backbone. RESULTS: A total of 1195 patients fulfilled the inclusion criteria: 696 started ART with a bPI, 315 with an InSTI and 184 with an NNRTI. During 2759 person-years of follow up, 642 patients experienced TF. Starting ART with bPIs [adjusted incidence rate ratio (aIRR) (95% CI) 1.62 (1.29-2.03) versus starting with NNRTIs; P 5 log10 HIV-RNA copies/mL, the durability of regimens based on InSTIs was longer than that of NNRTI- and bPI-based regimens

influence of bitter lupin on consumption and digestibility in organic dairy cattle soya bean free diets

One of the main principles of organic husbandry is that animal feed must be GMO free, and soya bean is well-known as a high risk GMO alimentary source. About 25 dry dairy cattle of the Italian Holstein breed, from the Cooperativa Emilio Sereni of Borgo S. Lorenzo (FI), were fed in two successive diets: the first with extruded soya bean (A), and the second in which bitter lupin, faba bean and proteinic pea substituted the soya bean (B). We evaluated both the consumption and the apparent digestibility (using acid insoluble ash as internal marker) of the two diets, repeating the trial twice. The presence of bitter lupin did not influence either the consumption of other feed, or the faecal water content. The apparent digestibility of the organic matter resulted satisfactory in both the diets, but was significantly higher in diet (A) than in diet (B) (71,6% vs 67,3%). In conclusion, even though we wish the cultivation of sweet lupin would be increase in Italy, we retain that also bitter lupin (mixed with other feed to increase the palatability) could be used as alternative protein source in dairy cattle diets