THE CONSTRUCTION OF MENTAL HEALTH ASSISTANCE AT TWO FAMILY HEALTH UNITS IN CUIABÁ-MATO GROSSO STATE/BRAZIL

El Programa Salud de la Familia (PSF) y la Reforma psiquiátrica prevén un cambio de modelo de atención quees la superación de prácticas médico-curativas. Examinar la dinámica de atención a la salud mental en dos unidades de PSFde Cuiabá, MT fue el objetivo de esta investigación, de foque cualitativo. El análisis de contenido fue identificado en trescategorías: la territorialidad, los recursos y la relación de servicios; proceso de trabajo de los equipos; red de atención dela salud mental; los resultados muestran la dificuldad de acceso, la precariedad de la infraestructura y vínculo frágil de lasunidades con la comunidad. Hubo demanda de los trastornos mentales en los dos, pero solamente en una la organizacióndel trabajo articulava la promoción de la salud mental en la comunidad. La red de referencia en salud mental fue desarticuladade las unidades estudiadas. Hay necesidades de iversiones técnico-asistenciales y políticas para consolidar la atención delos titulares de molestias mentales en el PSF.The Family Health Program and the Psychiatric Reform foresee a change in the caring model, surpassing themedical curing practices. This research study, with a qualitative approach, objectified to analyze mental health caringdynamics at two units of the Family Health Program in Cuiabá, Mato Grosso State/Brazil. Content analysis identified threecategories: unit coverage area, resources and services link; teams’ work process and mental health care network. Theresults evidenced access difficulties, a precarious infra-structure and fragile bonds between the units and the community.There was a caring demand of mental disorders in the two units, however in only one of them work organization articulatedmental health promotion within the community. The reference mental health network proved to be disarticulated in thoseunits. There is a need of investments in technical assistance and policies to consolidate mental health care in the FamilyHealth Program.O Programa Saúde da Família e a Reforma Psiquiátrica prevêem a mudança de modelo assistencial superandopráticas médico-curativas. Analisar a dinâmica assistencial à saúde mental em duas unidades do Programa Saúde daFamília-PSF de Cuiabá-MT foi o objetivo desta pesquisa de abordagem qualitativa. A análise de conteúdo identificou trêscategorias: territorialidade, recursos e vínculo dos serviços; processo de trabalho das equipes; rede assistencial em saúdemental. Os resultados mostram a dificuldade de acesso, infra-estrutura precária e vínculo frágil das unidades com acomunidade. Havia demanda de transtornos mentais nas duas unidades, porém somente em uma houve uma aproximaçãodo trabalho articulado à promoção da saúde mental na comunidade. A rede de referência em saúde mental destas unidadesse mostrou desarticulada. Há necessidade de investimentos técnico-assistenciais e políticos para consolidar a atençãoaos portadores de transtornos mentais no PSF

Microscopic Analysis of the Tupanvirus Cycle in Vermamoeba vermiformis

Since Acanthamoeba polyphaga mimivirus (APMV) was identified in 2003, several other giant viruses of amoebae have been isolated, highlighting the uniqueness of this group. In this context, the tupanviruses were recently isolated from extreme environments in Brazil, presenting virions with an outstanding tailed structure and genomes containing the most complete set of translation genes of the virosphere. Unlike other giant viruses of amoebae, tupanviruses present a broad host range, being able to replicate not only in Acanthamoeba sp. but also in other amoebae, such as Vermamoeba vermiformis, a widespread, free-living organism. Although the Tupanvirus cycle in A. castellanii has been analyzed, there are no studies concerning the replication of tupanviruses in other host cells. Here, we present an in-depth microscopic study of the replication cycle of Tupanvirus in V. vermiformis. Our results reveal that Tupanvirus can enter V. vermiformis and generate new particles with similar morphology to when infecting A. castellanii cells. Tupanvirus establishes a well-delimited electron-dense viral factory in V. vermiformis, surrounded by lamellar structures, which appears different when compared with different A. castellanii cells. Moreover, viral morphogenesis occurs entirely in the host cytoplasm within the viral factory, from where complete particles, including the capsid and tail, are sprouted. Some of these particles have larger tails, which we named “supertupans.” Finally, we observed the formation of defective particles, presenting abnormalities of the tail and/or capsid. Taken together, the data presented here contribute to a better understanding of the biology of tupanviruses in previously unexplored host cells

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Handbook of Active Ageing and Quality of Life: From Concepts to Applications

La edición de este libro estuvo a cargo de Fermina Rojo-Pérez y Gloria Fernández-Mayoralas.El documento adjunto contiene la cubierta, portada e índice del libro.This handbook presents an overview of studies on the relationship of active ageing and quality of life. It addresses the new challenges of ageing from the paradigm of positive ageing (active, healthy and successful) for a better quality of life. It provides theoretical perspectives and empirical studies, including scientific knowledge as well as practical experiences about the good ageing and the quality of later life around the world, in order to respond to the challenges of an aged population. The handbook is structured in 4 sections covering theoretical and conceptual perspectives, social policy issues and research agenda, methods, measurement instrument-scales and evaluations, and lastly application studies including domains and geographical contexts.Peer reviewe