An Overview of Transfer Conditions: Exploring Latino Community College Students in Texas

This paper begins exploring the transfer conditions for Latino community college students in Texas. We provide an overview of the high school schooling conditions for Latinos; the experiences of Latinos in the community college; and some models that can increase the transfer and graduation rates for Latina/o community college students.Educatio

An investigation into two photostable retinoids and their use as tools to study retinoid function in vivo.

All-trans retinoic acid (ATRA) is essential for embryonic development and adult homeostasis. Its study has been hindered by the fact that it can be converted to isomers upon exposure to light and because its metabolites are also bioactive molecules. Recent research has indicated that ATRA can also activate two different receptor pathways in vitro and in vivo. The present study investigates the effects of these isomers and metabolites on chick wing development using two synthetic, photostable retinoids, EC23 and EC19. These retinoids have identical structures bar the position of the terminal carboxylic acid group but surprisingly, generate different effects in vitro and in vivo, and are differentially metabolised by metabolising enzymes. EC23 mimics most of the effects of ATRA in vivo, including the novel phenotype of scapula malformation, while EC19 does not. Their phenotypes are further characterised in the text but EC23 produces a novel retinoid phenotype characterised by duplications of solely forelimb digit 1. The mechanisms behind the phenotypes generated by EC23 and EC19 are explored with respect to retinoid metabolism and localisation of ATRA binding proteins at the stage of application. Both ATRA signalling pathways are investigated at HH20 of chick embryonic development which improves our understanding of the role of retinoids in limb and embryonic development. Comparison of gene expression in response to ATRA and EC23 indicates that the metabolites and isomers of ATRA do not play a role in embryonic limb development, as well as highlighting avenues for further research into the development of the scapula and elbow. A major part of the retinoid response is to stall limb development while retinoid levels recover. By comparison with other teratogens, this may be part of a common response and be pertinent to the regulation of normal embryonic development by retinoids

Theorem Justification and Acquisition in Dynamic Geometry: A Case of Proof by Contradiction

Theorem acquisition and deductive proof have always been core elements in the study and teaching of Euclidean geometry. The introduction of dynamic geometry environments,DGE (e.g., Cabri-Géomètre, Geometer's Sketchpad), into classrooms in the past decade has posed a challenge to this praxis. Student scan experiment through different dragging modalities on geometrical objects that they construct, and consequently infer properties(generalities, theorems) about the geometrical artefacts. Because of the inductive nature of the DGE, the experimental-theoretical gap that exists in the acquisition and justification of geometrical knowledge becomes an important pedagogical and epistemological concern. In this paper, we will describe and study a ‘Cabri proof by contradiction’ of a theorem on cyclic quadrilaterals given by a pair of 16 year-old students in a Hong Kong secondary school. We will discuss how their construction motivates a visual-cognitive scheme on `seeing' proof in DGE, and how this scheme could fit into the theoretical construct of cognitive unity of theorems proposed by Boero, Garuti and Mariotti(1996). The issue of a cognitive duality and its relation to visualization will be raised and discussed. Finally, we propose a possible perspective to bridge the experimental-theoretical gap in DGE by introducing the idea of a dynamic template as a visualizer to geometrical theorem justification and acquisition.postprin

Properties of tangential and cyclic polygons: an application of circulant matrices

In this paper, the properties of tangential and cyclic polygons proposed by Lopez-Real are proved rigorously using the theory of circulant matrices. In particular, the concepts of slippable tangential polygons and conformable cyclic polygons are defined. It is shown that an n-sided tangential (or cyclic) polygon Pn with n even is slippable (or conformable) and the sum of a set of non-adjacent sides (or interior angles) of Pn satisfies certain equalities. On the other hand, for a tangential (or cyclic) polygon Pn with n odd, it is rigid and the sum of a set of non-adjacent sides (or interior angles) of Pn satisfies certain inequalities. These inequalities give a definite answer to the question raised by Lopez-Real concerning the alternating sum of interior angles of a cyclic polygon.postprin

Sargadelos: patrimonio cultural, memorístico y turístico

[EN] This article studies Sargadelos ceramics from an identity perspective. It begins by analyzing what were its origins and the evolution that this production has had until today. The exceptional character that this Galician earthenware undertaken in the nineteenth century and that was an exponent of modernity stands out. Díaz Pardo finds in this material a support where to give visibility and rescue a cultural period that had been forgotten. A recovery process that concluded, thanks to the support of exiled intellectuals in Argentina, with the creation of the Forms Laboratory and the manufacture of a ceramic that becomes the symbol of Galicia. Currently, Sargadelos pottery is a tourist attraction and has managed to echo nationally and internationally.[ES] En este artículo se aborda la cerámica de Sargadelos desde la perspectiva de la identidad. Para ello se comienza analizando cuáles fueron sus orígenes y la evolución que esta producción ha tenido hasta la actualidad. Se destaca el carácter excepcional que ha conseguido esta loza gallega emprendida en el siglo XIX y que fue un exponente de modernidad. Díaz Pardo encuentra en este material un soporte donde dar visibilidad y rescatar un periodo cultural que había caído en el olvido. Un proceso de recuperación que concluyó, gracias al apoyo de los intelectuales exiliados en Argentina, con la creación del Laboratorio de Formas y la fabricación de una cerámica que se convierte en el símbolo de Galicia. Actualmente, la cerámica de Sargadelos es un reclamo turístico y ha conseguido tener eco a nivel nacional e internacional.Real Lopez, I. (2021). Sargadelos: patrimonio cultural, memorístico y turístico. En I Simposio anual de Patrimonio Natural y Cultural ICOMOS España. Editorial Universitat Politècnica de València. 35-42. https://doi.org/10.4995/icomos2019.2019.11405OCS354

Intra-abdominal desmoid tumors in familial adenomatous polyposis: How much do clinical and surgical variables interfere with their development?

Objective: Familial Adenomatous Polyposis is a complex hereditary disease that exposes the carrier to a great risk of Colorectal Cancer (CRC). After prophylactic surgery, intra-abdominal desmoid tumors are known to be one the most important cause of death. Therefore, recognition of increased-risk patients and modification of operative strategy may be crucial. Aim: The objective of this study was to estimate the desmoid tumor risk in relation to various surgical and clinical variables. Methods: Patients who had undergone polyposis since 1958 were included in the study. After exclusion criteria were met, those who had developed desmoid tumors were selected to undergo further evaluation. Results: The study revealed that the risk of developing desmoid tumors was associated with various factors such as sex ratio, colectomy, and reoperations. On the other hand, the type of surgery, family history, and surgical approach did not affect the risk of developing desmoid tumors. The data collected from 146 polyposis patients revealed that 16% had desmoid polyps. The sex ratio was 7:1, and the median age at colectomy was 28.6 years. Family history, multiple abdominal operations, and reoperations were some of the characteristics that were common in desmoid patients. Conclusion: Recognition of clinical (female sex) and surgical (timing of surgery and previous reoperations) data as unfavorable variables associated with greater risk may be useful during the decision-making process

Muscle glycogen unavailability and fat oxidation rate during exercise: Insights from McArdle disease

Glycogen store disease; Muscle fatigue; Substrate oxidationEnfermedad de almacenamiento de glucógeno; Fatiga muscular; Oxidación del sustratoMalaltia d'emmagatzematge de glucogen; Fatiga muscular; Oxidació del substratCarbohydrate availability affects fat metabolism during exercise; however, the effects of complete muscle glycogen unavailability on maximal fat oxidation (MFO) rate remain unknown. Our purpose was to examine the MFO rate in patients with McArdle disease, comprising an inherited condition caused by complete blockade of muscle glycogen metabolism, compared to healthy controls. Nine patients (three women, aged 36 ± 12 years) and 12 healthy controls (four women, aged 40 ± 13 years) were studied. Several molecular markers of lipid transport/metabolism were also determined in skeletal muscle (gastrocnemius) and white adipose tissue of McArdle (Pygm p.50R∗/p.50R∗) and wild-type male mice. Peak oxygen uptake (V˙O2peak), MFO rate, the exercise intensity eliciting MFO rate (FATmax) and the MFO rate-associated workload were determined by indirect calorimetry during an incremental cycle-ergometer test. Despite having a much lower V˙O2peak (24.7 ± 4 vs. 42.5 ± 11.4 mL kg−1 min−1, respectively; P < 0.0001), patients showed considerably higher values for the MFO rate (0.53 ± 0.12 vs. 0.33 ± 0.10 g min−1, P = 0.001), and for the FATmax (94.4 ± 7.2 vs. 41.3 ± 9.1 % of V˙O2peak, P < 0.0001) and MFO rate-associated workload (1.33 ± 0.35 vs. 0.81 ± 0.54 W kg−1, P = 0.020) than controls. No between-group differences were found overall in molecular markers of lipid transport/metabolism in mice. In summary, patients with McArdle disease show an exceptionally high MFO rate, which they attained at near-maximal exercise capacity. Pending more mechanistic explanations, these findings support the influence of glycogen availability on MFO rate and suggest that these patients develop a unique fat oxidation capacity, possibly as an adaptation to compensate for the inherited blockade in glycogen metabolism, and point to MFO rate as a potential limiting factor of exercise tolerance in this disease.Research by the IA and CR-L group is funded by the Biomedical Research Networking Centre on Frailty and Healthy Aging (CIBERFES, CB16/10/00314 and CB16/10/00477). IR-G is supported by a postdoctoral contract from Universidad de Castilla–La Mancha (2021/5937). PLV is supported by a Sara Borrell contract from Instituto de Salud Carlos III (CD21/00138). Research by AL and TP is funded by the Spanish Ministry of Economy and Competitiveness and Fondos FEDER (PI18/00139 and PI19/01313, respectively)

Mechanical properties and fire-resistance of composites with marble particles

The main aim of this work is to manufacture a composite material based on a natural material (marble) with acceptable mechanical properties and fire resistance, for being used in habitat industry as floor or wall in buildings. Marble used as raw material is the waste powder of quarry or plate manufacturing. To achieve this objective, polyester matrix composites with 50 wt.% of marble and 3 wt.% of glass fiber (short fiber or mesh) were prepared. The novelty of this study is the high percentage of ceramic material added to a polymer matrix composite and the fire resistance study. Samples were characterized mechanically through flexural test, Charpy impact test, compression test and wear resistance by pin-on-disk test. Fracture surfaces were analyzed by scanning electron microscope (SEM), and wear tracks were studied by SEM and 3D optical profilometer. Besides, samples were subjected to fire test using a Bunsen burner at 900 °C for 20 min. Sample temperature at the opposite-to-fire test side was measured with an infrared thermometer. Results show that marble improves mechanical properties of polyester and the effect of the glass fiber depends on its morphology (fiber or mesh). Fire resistance is high, and the fire goes out when the flame is turned off. Furthermore, the mesh maintains the integrity of the sample.This research received funding from the SUDOE project SOE1/P1/E307

Generation of induced pluripotent stem cells (iPSCs) from a Bernard–Soulier syndrome patient carrying a W71R mutation in the GPIX gene

AbstractWe generated an induced pluripotent stem cell (iPSC) line from a Bernard–Soulier Syndrome (BSS) patient carrying the mutation p.Trp71Arg in the GPIX locus (BSS1-PBMC-iPS4F4). Peripheral blood mononuclear cells (PBMCs) were reprogrammed using heat sensitive non-integrative Sendai viruses containing the reprogramming factors Oct3/4, SOX2, KLF4 and c-MYC. Successful silencing of the exogenous reprogramming factors was checked by RT-PCR. Characterization of BSS1-PBMC-iPS4F4 included mutation analysis of GPIX locus, Short Tandem Repeats (STR) profiling, alkaline phosphatase enzymatic activity, analysis of conventional pluripotency-associated factors at mRNA and protein level and in vivo differentiation studies. BSS1-PBMC-iPS4F4 will provide a powerful tool to study BSS