U.dream goes to market - an evaluation of crescer com consciência and analysis of the internal and external environments affecting its strategic pPosition

U.Dream is a social enterprise targeted at developing social leadership skills. It recently launched U.Purpose (service) and Crescer com Consciência (product) aiming to ensure future financial sustainability. However, these were launched without conducting a market research and clear guiding strategy. The focus of this project is to assess the attractiveness of the CSR and children’s book markets and U.Dream’s current strategy, providing a strategic revision. An in-depth analysis concluded that, in order to face the stagnant book market conditions and the fierce competition, the way for the Crescer com Consciência initiative to prosper is through differentiation and effective communicatio

Thermal vorticity production in relativistic dissipative fluids

We have computed the circulation integrations of thermal vorticity with and without charged currents in dissipative fluids. We find that the relativistic Kelvin circulation theorem will be modified by the dissipative effects, therefore, the circulation integrations of thermal vorticity may not be conserved during the fluid evolution.Comment: Presented by S. Pu at Critical Point and Onset of Deconfinement (CPOD), Wroclaw, Poland, May 30 - June 4, 201

Diabetic Retinal Neurodegeneration Is Associated With Mitochondrial Oxidative Stress and Is Improved by an Angiotensin Receptor Blocker in a Model Combining Hypertension and Diabetes

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)OBJECTIVE-Diabetic retinopathy displays the features of a neurodegenerative disease. Oxidative stress is involved in the pathogenesis of diabetic retinopathy. This investigation sought to determine whether hypertension exacerbates the oxidative stress, neurodegeneration, and mitochondrial dysfunction that exists in diabetic retinopathy and whether these changes could be minimized by the angiotensin II type 1 (AT(1)) receptor blocker (ARB) losartan. RESEARCH DESIGN AND METHODS-Diabetes was induced in spontaneously hypertensive rats (SHRs) and normotensive Wistar Kyoto (WKY) rats. The diabetic SHRs were assigned to receive or not: receive losartan. RESULTS-The level of apoptosis in the retina was higher in diabetic WKY rat's than in the control group, and higher levels were found in diabetic SHRs. The apoptotic cells expressed neural and glial markets. The retinal glial reaction was more evident in diabetic WKY rats and was markedly accentuated in diabetic SHRs. Superoxide production in retinal tissue increased in diabetic WKY rats, and a greater increase occurred in diabetic SHRs. Glutathione levels decreased only in diabetic SHRs. As a consequence, the levels of nitrotyrosine and 8-hydroxy 2'-deoxyguanosine, markers of oxidative stress, were elevated in diabetic groups, mainly in diabetic SHRs. Mitochondrial integrity was dramatically affected in the diabetic groups. The ARB treatment reestablished all of the above-mentioned parameters. CONCLUSIONS-These findings suggest that concomitance of hypertension and diabetes exacerbates oxidative stress, neurodegeneration, and mitochondrial dysfunction in the retinal cells. These data provide the first evidence of AT, blockage as a neuroprotective treatment of diabetic retinopathy by reestablishing oxidative redox and the mitochondrial function. Diabetes 58:1382-1390, 200958613821390Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)FAPESP [04/00455-9, 05/58189-5

Deficient Autophagy Contributes to the Development of Diabetic Retinopathy

Autophagy is a self-degradation process essential to maintain intracellular homeostasis and cell survival, controlling elimination of pathogens, damage to organelles, and nutrient recycling to generate energy. Alterations in autophagic flux have been reported in the mechanisms of several diseases such as neurodegenerative diseases, cancer, diabetes mellitus, and its associated complications. Diabetic retinopathy (DR) is a microvascular complication of diabetes, affecting nearly 30% of diabetic patients. Several pathways are triggered and repressed in the development of DR, and autophagy showed to be relevant in the pathogenesis of this devastating complication. In this chapter, autophagy’s involvement in the development and progression of DR will be discussed, mainly in retinal pigmented epithelial cells and retinal microvascular endothelial cells, as well as in Müller cells—the more prominent retinal glial cell

Qualidade do solo sob cultivo de banana em sistemas de produção orgânico e convencional em Gonçalves (MG)

A bananicultura, produção de banana, vem recebendo notório destaque na região Sul de Minas Gerais, visto o cultivo ser favorecido pelas condições edafoclimáticas, altitude e manejo cultural adotado pelos produtores. Este aumento denota a importância de avaliar os impactos da produção sobre a qualidade do solo, independente do sistema de produção adotado, seja ele orgânico ou convencional, podendo esta ser realizada por meio de indicadores. Diante do contexto, propôs-se avaliar a qualidade do solo em função dos diferentes sistemas de produção orgânico e convencional de banana mediante análise integrada dos atributos físicos, químicos, microbiológicos e visuais, tendo como referência uma área de mata nativa. As amostras deformadas e indeformadas foram coletadas na profundidade de 0 a 20 cm, no município de Gonçalves (MG) e submetidas às análises físicas (textura, densidade do solo, densidade de partículas, porosidade total, diâmetro médio geométrico e ponderado), químicas (fertilidade básica e matéria orgânica), microbiológicas (carbono da biomassa microbiana, atividade microbiana e qCO2), e realizada análise visual de indicadores relacionados ao solo, vegetação, fauna do solo e silvestre. Os resultados indicam que as práticas culturais e o manejo do solo adotado no sistema de produção orgânico e convencional contribuíram para um aporte expressivo de matéria orgânica atribuído à constante deposição da biomassa da bananeira, sem diferença com a área de referência de mata nativa, havendo, dessa forma, manutenção da qualidade física, microbiológica e visual do solo. Os indicadores químicos apresentaram condições químicas favoráveis ao desenvolvimento do plantel nos sistemas orgânicos, e em especial nos sistemas convencionais, onde, além do material orgânico depositado, houve adição de insumos químicos. Ressalta-se as limitações da seleção dos indicadores químicos, os quais não avaliaram os efeitos dos insumos químicos utilizados nos sistemas convencionais, sendo este, o principal fator que diferencia o manejo realizado nos sistemas orgânicos e convencionais

Santa Maria de Guimarães. A jurisdição da sua igreja. IIª Parte.

31 (4) Out.-Dez. 1921, p. 317-323

Velharias Vimaranenses. A Confraria e Irmandade de Nossa Senhora da Oliveira, sua festa e procissão nos séculos XVII e XVIII. Extractos de alguns livros dos arquivos da Irmandade e do Cabido. IIª Parte.

44 (3-4) Jul.-Dez. 1934, p. 189-194

Os cónegos da Oliveira. Tesouro da Colegiada.

36 (1) Jan.-Mar. 1926, p. 40-45

Santa Maria de Guimarães. A jurisdição da sua igreja. Vª Parte.

36 (2-3) Abr.-Set. 1926, p. 133-136

Arquivo da Colegiada de Guimarães. XIIIª Parte.

35 (1) Jan.-Mar. 1925, p. 9-12