Filamentary Star Formation: Observing the Evolution toward Flattened Envelopes

Filamentary structures are ubiquitous from large-scale molecular clouds (few parsecs) to small-scale circumstellar envelopes around Class 0 sources (~1000 AU to ~0.1 pc). In particular, recent observations with the Herschel Space Observatory emphasize the importance of large-scale filaments (few parsecs) and star formation. The small-scale flattened envelopes around Class 0 sources are reminiscent of the large-scale filaments. We propose an observationally derived scenario for filamentary star formation that describes the evolution of filaments as part of the process for formation of cores and circumstellar envelopes. If such a scenario is correct, small-scale filamentary structures (0.1 pc in length) with higher densities embedded in starless cores should exist, although to date almost all the interferometers have failed to observe such structures. We perform synthetic observations of filaments at the prestellar stage by modeling the known Class 0 flattened envelope in L1157 using both the Combined Array for Research in Millimeter-wave Astronomy (CARMA) and the Atacama Large Millimeter/Submillimeter Array (ALMA). We show that with reasonable estimates for the column density through the flattened envelope, the CARMA D-array at 3mm wavelengths is not able to detect such filamentary structure, so previous studies would not have detected them. However, the substructures may be detected with CARMA D+E array at 3 mm and CARMA E array at 1 mm as a result of more appropriate resolution and sensitivity. ALMA is also capable of detecting the substructures and showing the structures in detail compared to the CARMA results with its unprecedented sensitivity. Such detection will confirm the new proposed paradigm of non-spherical star formation.Comment: 9 pages, 10 figures. Accepted by Ap

A Flattened Protostellar Envelope in Absorption around L1157

Deep Spitzer IRAC images of L1157 reveal many of the details of the outflow and the circumstellar environment of this Class 0 protostar. In IRAC band 4, 8 microns, there is a flattened structure seen in absorption against the background emission. The structure is perpendicular to the outflow and is extended to a diameter of 2 arcminutes. This structure is the first clear detection of a flattened circumstellar envelope or pseudo-disk around a Class 0 protostar. Such a flattened morphology is an expected outcome for many collapse theories that include magnetic fields or rotation. We construct an extinction model for a power-law density profile, but we do not constrain the density power-law index.Comment: ApJL accepte

TCR Convergence in Individuals Treated With Immune Checkpoint Inhibition for Cancer.

Tumor antigen-driven selection may expand T cells having T cell receptors (TCRs) of shared antigen specificity but different amino acid or nucleotide sequence in a process known as TCR convergence. Substitution sequencing errors introduced by TCRβ (TCRB) repertoire sequencing may create artifacts resembling TCR convergence. Given the anticipated differences in substitution error rates across different next-generation sequencing platforms, the choice of platform could be consequential. To test this, we performed TCRB sequencing on the same peripheral blood mononuclear cells (PBMC) from individuals with cancer receiving anti-CTLA-4 or anti-PD-1 using an Illumina-based approach (Sequenta) and an Ion Torrent-based approach (Oncomine TCRB-LR). While both approaches found similar TCR diversity, clonality, and clonal overlap, we found that Illumina-based sequencing resulted in higher TCR convergence than with the Ion Torrent approach. To build upon this initial observation we conducted a systematic comparison of Illumina-based TCRB sequencing assays, including those employing molecular barcodes, with the Oncomine assay, revealing differences in the frequency of convergent events, purportedly artifactual rearrangements, and sensitivity of detection. Finally, we applied the Ion Torrent-based approach to evaluate clonality and convergence in a cohort of individuals receiving anti-CTLA-4 blockade for cancer. We found that clonality and convergence independently predicted response and could be combined to improve the accuracy of a logistic regression classifier. These results demonstrate the importance of the sequencing platform in assessing TCRB convergence

Probing the Protostellar Envelope around L1157: the Dust and Gas Connection

We present observations of the Class 0 protostar L1157-mm using the Combined Array for Research in Millimeter-wave Astronomy (CARMA) in 3 mm dust continuum and N2H+ line emission. In the N2H+ line, we detect a large-scale envelope extended over a linear size of ~20,000AU flattened in the direction perpendicular to the outflow. This N2H+ feature coincides with the outer envelope seen in the 8 micron extinction by Looney et al. Meanwhile, the dust continuum traces the compact, nearly spherical structure of the inner envelope, where N2H+ becomes depleted. This highly flattened N2H+ envelope also shows dynamical signatures consistent with gravitational infall in the inner region, but a slow, solid-body rotation at large scales. This flattened structure is not a rotationally supported circumstellar disk; instead, it resembles a prestellar core both morphologically and kinematically, representing the early phase of a Class 0 system. In this paper, we construct a simple model to interpret both the dust continuum and N2H+ emission and suggest a possible dynamical scenario for the overall properties of the envelope.Comment: Accepted for publication by the ApJ, 34 pages, 10 figures and 2 table

Comparative Cost Analysis of Alternative Animal Tracing Strategies Directed Toward Foot and Mouth Disease Outbreaks in the Texas High Plains

The primary objective of this study is to evaluate the industry impact of a hypothetical Foot and Mouth Disease (FMD) outbreak in the Texas High Plains using alternative animal tracing levels. To accomplish this objective, an epidemiological disease spread model, AUSSPREAD, is used to simulate the FMD outbreak and an economic model is used to examine the impacts of different animal identification levels in cattle. The different levels of animal identification relate to the model?s ability to trace back the subsequent infected and/or dangerous contacts with which the initial outbreak herd has been in contact. The study examines direct disease management costs (slaughter, euthanasia, disposal, surveillance, and cleaning disinfection), forgone income, and other indirect costs (indemnity payments and welfare slaughter) for outbreaks originating from a large beef operation, a feedlot, and a saleyard across subsequent tracing periods from 1 to 10 days. Welfare slaughter and quarantine costs were estimated for the best and worst outbreaks from the feedlot operation. It is noteworthy that total direct costs of a FMD outbreak would be more extensive than the current study's calculations, which only analyzed the direct disease management costs. The increased days to trace dangerous contacts presented overall increases in outbreak losses over each outbreak scenario. Although outcome averages appear insensitive at times under the assumptions applied, the epidemiological model presented the possibility that traceability could reduce the risk of extreme outcomes in respect to the overall distribution of losses. For each cattle operation, the outbreaks stayed consistent or marginally increased with their respective average costs, but their maximum losses rose steadily, across the trace periods examined. The impact of increased traceability and decreased outbreak length can be justified in affecting FMD outbreak costs in a positive manner. The results provide the industry with estimations of different outbreak scenarios which can be used to inform the decision on the NAIS system. Longer tracing periods, larger simulations (by iteration), and further study of the model is necessary in order to more accurately imitate FMD outbreaks within the Texas High Plains and its detrimental effects