The impact and penetration of location-based services

Since the invention of digital technology, its development has followed an entrenched path ofminiaturisation and decentralisation with increasing focus on individual and niche applications. Computerhardware has moved from remote centres to desktop and hand held devices whilst being embedded invarious material infrastructures. Software has followed the same course. The entire process has convergedon a path where various analogue devices have become digital and are increasingly being embedded inmachines at the smallest scale. In a parallel but essential development, there has been a convergence ofcomputers with communications ensuring that the delivery and interaction mechanisms for computersoftware is now focused on networks of individuals, not simply through the desktop, but in mobilecontexts. Various inert media such as fixed television is becoming more flexible as computers and visualmedia are becoming one.With such massive convergence and miniaturisation, new software and new applications define the cuttingedge. As computers are being increasingly tailored to individual niches, then new digital services areemerging, many of which represent applications which hitherto did not exist or at best were rarely focusedon a mass market. Location based services form one such application and in this paper, we will bothspeculate on and make some initial predictions of the geographical extent to which such services willpenetrate different markets. We define such services in detail below but suffice it to say at this stage thatsuch functions involve the delivery of traditional services using digital media and telecommunications.High profile applications are now being focused on hand held devices, typically involving information onproduct location and entertainment but wider applications involve fixed installations on the desktop whereservices are delivered through traditional fixed infrastructure. Both wire and wireless applications definethis domain. The market for such services is inevitably volatile and unpredictable at this early stage but wewill attempt here to provide some rudimentary estimates of what might happen in the next five to tenyears.The ?network society? which has developed through this convergence, is, according to Castells (1989,2000) changing and re-structuring the material basis of society such that information has come todominate wealth creation in a way that information is both a raw material of production and an outcome ofproduction as a tradable commodity. This has been fuelled by the way technology has expanded followingMoore?s Law and by fundamental changes in the way telecommunications, finance, insurance, utilitiesand so on is being regulated. Location based services are becoming an integral part of this fabric and thesereflect yet another convergence between geographic information systems, global positioning systems, andsatellite remote sensing. The first geographical information system, CGIS, was developed as part of theCanada Land Inventory in 1965 and the acronym ?GIS? was introduced in 1970. 1971 saw the firstcommercial satellite, LANDSAT-1. The 1970s also saw prototypes of ISDN and mobile telephone and theintroduction of TCP/IP as the dominant network protocol. The 1980s saw the IBM XT (1982) and thebeginning of de-regulation in the US, Europe and Japan of key sectors within the economy. Finally in the 1990s, we saw the introduction of the World Wide Web and the ubiquitous pervasion of business andrecreation of networked PC?s, the Internet, mobile communications and the growing use of GPS forlocational positioning and GIS for the organisation and visualisation of spatial data. By the end of the 20thcentury, the number of mobile telephone users had reached 700 million worldwide. The increasingmobility of individuals, the anticipated availability of broadband communications for mobile devices andthe growing volumes of location specific information available in databases will inevitably lead to thedemand for services that will deliver location related information to individuals on the move. Suchlocation based services (LBS) although in a very early stage of development, are likely to play anincreasingly important part in the development of social structures and business in the coming decades.In this paper we begin by defining location based services within the context we have just sketched. Wethen develop a simple model of the market for location-based services developing the standard non-linearsaturation model of market penetration. We illustrate this for mobile devices, namely mobile phones in thefollowing sections and then we develop an analysis of different geographical regimes which arecharacterised by different growth rates and income levels worldwide. This leads us to speculate on theextent to which location based services are beginning to take off and penetrate the market. We concludewith scenarios for future growth through the analogy of GIS and mobile penetration

Predicting microscale shifts in the distribution of the butterfly Plebejus argus at the northern edge of its range

This is the final version of the article. Available from Wiley via the DOI in this recordSpecies are often observed to occur in restricted patches of particularly warm microclimate at their high latitude/altitude geographic range margin. In these areas, global warming is expected to cause small-scale expansion of the occupied area, but most previous studies of range expansion have used very coarse scale data. Using high resolution microclimate models together with detailed field surveys, we tested whether the butterfly Plebejus argus, occurring on limestone grassland in north Wales, was responding as might be expected due to climate change in the last 30-40 yr. The abundance of adult Plebejus argus at 100 m resolution in 2011 was strongly affected by elevation and near-ground temperatures in May. A statistical model including microclimate, fitted to 2011 data, was successful (67% correct) at hindcasting the occurrence of Plebejus argus in 1983 when the average May air temperature was 1.4°C cooler. However, the model was less accurate at hindcasting occurrences in 1972 (50% correct). Given the distribution of micro-sites in this landscape, we predict that further warming of approximately 1°C would make the majority of sites highly microclimatically suitable for this species. There are a growing number of long-term studies of range change, and investigations into the mechanisms driving them, but still surprisingly few that explicitly make and test predictions with independent data. Our tests are a valuable example of how accurate predictions of distribution change can be, but also of the inevitable uncertainties. Improved understanding of how well models predict will be very important to plan robust climate change adaptation measures.JAH, JJB, RJW and CDT were supported by NERC grant NE/G006377/1 (). Fieldwork by JAH and NL was supported by a pump-priming grant from the Dept of Biology, Univ. of York

Cutaneous Adenoid Cystic Carcinoma with Perineural Invasion Treated by Mohs Micrographic Surgery—A Case Report with Literature Review

We report a 58-year-old woman with cutaneous adenoid cystic carcinoma arising on the chest treated with Mohs micrographic surgery. The patient remained tumor-free at 24-month follow-up. To date, only six other cases of cutaneous adenoid cystic carcinoma were reportedly managed by Mohs surgery. Cutaneous adenoid cystic carcinoma has low potential for distant metastasis but is notorious for its aggressive infiltrative growth pattern, frequent perineural invasion, and high risk of local recurrence after excision. We propose that Mohs surgery is an ideal method to achieve margin-free removal of cutaneous adenoid cystic carcinoma. A brief literature review is provided

Determine TB-LAM point-of-care tuberculosis assay predicts poor outcomes in outpatients during their first year of antiretroviral therapy in South Africa.

BACKGROUND: Determine TB-LAM is the first point-of-care test (POC) for HIV-associated tuberculosis (TB) and rapidly identifies TB in those at high-risk for short-term mortality. While the relationship between urine-LAM and mortality has been previously described, the outcomes of those undergoing urine-LAM testing have largely been assessed during short follow-up periods within diagnostic accuracy studies. We therefore sought to assess the relationship between baseline urine-LAM results and subsequent hospitalization and mortality under real-world conditions among outpatients in the first year of ART. METHODS: Consecutive, HIV-positive adults with a CD4 count < 100 cells/uL presenting for ART initiation were enrolled. TB diagnoses and outcomes (hospitalization, loss-to-follow and mortality) were recorded during the first year following enrolment. Baseline urine samples were retrospectively tested using the urine-LAM POC assay. Kaplan Meier survival curves were used to assess the cumulative probability of hospitalization or mortality in the first year of follow-up, according to urine-LAM status. Cox regression analyses were performed to determine independent predictors of hospitalization and mortality at  three months and one year of follow-up. RESULTS: 468 patients with a median CD4 count of 59 cells/uL were enrolled. There were 140 patients (29.9%) with newly diagnosed TB in the first year of follow-up of which 79 (56.4%) were microbiologically-confirmed. A total of 18% (n = 84) required hospital admission and 12.2% (n = 57) died within a year of study entry. 38 out of 468 (8.1%) patients retrospectively tested urine-LAM positive - including 19.0% of those with microbiologically-proven TB diagnoses (n = 15/79) and 23.0% (n = 14/61) of those with clinical-only TB diagnoses; 9 of 38 (23.7%) of patients retrospectively testing LAM positive were never diagnosed with TB under routine program conditions. Among all patients (n = 468) in the first year of follow-up, a positive urine-LAM result was strongly associated with all-cause hospitalization and mortality with a corresponding adjusted hazard ratio (aHR) of 3.7 (95%CI, 1.9-7.1) and 2.6 (95%, 1.2-5.7), respectively. CONCLUSIONS: Systematic urine-LAM testing among ART-naïve HIV-positive outpatients with CD4 counts < 100 cells/uL detected TB cases that were missed under routine programme conditions and was highly predictive for subsequent hospitalization and mortality in the first year of ART

Evaluation of a novel point-of-care cryptococcal antigen test on serum, plasma, and urine from patients with HIV-associated cryptococcal meningitis.

BACKGROUND: Many deaths from cryptococcal meningitis (CM) may be preventable through early diagnosis and treatment. An inexpensive point-of-care (POC) assay for use with urine or a drop of blood would facilitate early diagnosis of cryptococcal infection in resource-limited settings. We compared cryptococcal antigen (CRAG) concentrations in plasma, serum, and urine from patients with CM, using an antigen-capture assay for glucuronoxylomannan (GXM) and a novel POC dipstick test. METHODS: GXM concentrations were determined in paired serum, plasma, and urine from 62 patients with active or recent CM, using a quantitative sandwich enzyme-linked immunosorbent assay (ELISA). A dipstick lateral-flow assay developed using the same monoclonal antibodies for the sandwich ELISA was tested in parallel. Correlation coefficients were calculated using Spearman rank test. RESULTS: All patients had detectable GXM in serum, plasma, and urine using the quantitative ELISA. Comparison of paired serum and plasma showed identical results. There were strong correlations between GXM levels in serum/urine (r(s) = 0.86; P < .001) and plasma/urine (r(s) = 0.85; P < .001). Levels of GXM were 22-fold lower in urine than in serum/plasma. The dipstick test was positive in serum, plasma, and urine in 61 of 62 patients. Dipstick titers correlated strongly with ELISA. Correlations between the methods were 0.93 (P < .001) for serum, 0.94 (P < .001) for plasma, and 0.94 (P < .001) for urine. CONCLUSIONS: This novel dipstick test has the potential to markedly improve early diagnosis of CM in many settings, enabling testing of urine in patients presenting to health care facilities in which lumbar puncture, or even blood sampling, is not feasible

Strategic behaviours in a labour market with mobility-restricting contractual provisions: evidence from the National Hockey League

We follow workers' performance along an unbalanced panel dataset over multiple years and study how performance varies at the end of fixed-term contracts, in a labour market where some people face a mobility restricting clause (i.e., a noncompete clause). Focusing on the labour market of the National Hockey League, we analyse players' performance data and contracts with a fixed effect estimator to address empirical limitations in previous studies. We find that, on average, NHL players' performance does not vary. However, our estimations detect substantially heterogeneous behaviours, depending on tenure, perceived expected performance and mobility. Only younger players (i.e., restricted free-agents) with high expected mobility but low expected performance tend to behave strategically and perform better. Differently, older players (i.e., unrestricted free-agents) with high expected mobility tend to underperform, as the option of moving back to European tournaments is more appealing

A Whole-child, whole-family approach to health assessments for asylum-seeking children

In 2020, 21% of people who sought asylum in the UK were children. This population has complex interconnecting health and social needs. Assessment requires a holistic approach, with consideration of physical and mental health in addition to social and developmental well-being, within the whole family group. A trauma-informed life-cycle and intergenerational care approach is important. This article, aimed at all health professionals who may work with asylum-seeking families, outlines the best practice principles for undertaking health assessments in migrant children and young people

Induction of Endothelial Cell Apoptosis by Solid Tumor Cells

peer reviewedThe mechanisms by which tumor cells extravasate to form metastasis remain controversial. Previous studies performed in vivo and in vitro demonstrate that the contact between tumor cells and the vascular wall impairs endothelium integrity. Here, we investigated the effect of breast adenocarcinoma MCF-7 cells on the apoptosis of human umbilical vein endothelial cells (HUVEC). TUNEL labeling, nuclear morphology, and DNA electrophoresis indicated that MCF-7 cells induced a two- to fourfold increase in HUVEC apoptosis. Caspase-3 activity was significantly enhanced. Neither normal cells tested (mammary epithelial cells, fibroblasts, leukocytes) nor transformed hematopoietic cells tested (HL60, Jurkat) induced HUVEC apoptosis. On the contrary, cells derived from solid tumors (breast adenocarcinoma, MDA-MB-231 and T47D; fibrosarcoma, HT 1080) had an effect similar to that of MCF-7 cells. The induction of apoptosis requires cell-to-cell contact, since it could not be reproduced by media conditioned by MCF-7 cells cultured alone or cocultured with HUVEC. Our results suggest that cells derived from solid tumors may alter the endothelium integrity by inducing endothelial cell apoptosis. On the contrary, normal or malignant leukocytes appear to extravasate by distinct mechanisms and do not damage the endothelium. Our data may lead to a better understanding of the steps involved in tumor cell extravasation

A Study of Cosmic Ray Composition in the Knee Region using Multiple Muon Events in the Soudan 2 Detector

Deep underground muon events recorded by the Soudan 2 detector, located at a depth of 2100 meters of water equivalent, have been used to infer the nuclear composition of cosmic rays in the "knee" region of the cosmic ray energy spectrum. The observed muon multiplicity distribution favors a composition model with a substantial proton content in the energy region 800,000 - 13,000,000 GeV/nucleus.Comment: 38 pages including 11 figures, Latex, submitted to Physical Review