Comparative studies on the therapeutic and adverse effects of mirtazapine and fluoxetine in the treatment of adult depression

Purpose: To evaluate comparatively the therapeutic and adverse effects of mirtazapine and fluoxetine for the management of adult depression.Methods: Adults (58) with depression admitted to the Neurology Department of Zaozhuang Municipal Hospital from August 2014 to July 2016 were randomly assigned to either mirtazapine group or fluoxetine group. Those in mirtazapine group were given mirtazapine while the fluoxetine group took fluoxetine. The patients were graded for Hamilton Depression Scale (HAMD) and Treatment Emergent Symptoms Scale (TESS) scores before treatment and at weeks 2, 4, 6, and 8 post-treatment, with the aim of comparing therapeutic effects and adverse reactions to mirtazapine and fluoxetine.Results: The therapeutic effects seen in the two groups did not differ significantly (p > 0.05), but mirtazapine had a slight advantage over fluoxetine. Effectiveness appeared after 2 weeks in the mirtazapine group, and 4 weeks in the other group. Moreover, there were significant differences in HAMD scores between the two groups after 2 and 4 weeks of treatment (p < 0.05), but the differences in scores after 6 and 8 weeks of treatment were not significant (p > 0.05). However, there were significant differences in score between pretreatment and 8-week post-treatment scores (p < 0.05). Mirtazapine group also had lower incidents of adverse reactions (sleepiness, dyspepsia, nausea, vomiting, excitation, and headache) than the fluoxetine group (p < 0.05).Conclusion: Mirtazapine has similar effect as fluoxetine in the treatment of adult depression, but works faster, with low incidence of adverse reactions. Thus, it is a safer and quicker antidepressant for clinical application.Keywords: Mirtazapine, Fluoxetine, Adult depression, Clinical effect, Adverse reaction

High sensitivity HI image of diffuse gas and new tidal features in M51 observed by FAST

We observed the classical interacting galaxy M51 with FAST and obtain high sensitivity HI image with column density down to 3.8 $\times$ 10$^{18}$ cm$^{-2}$. In the image we can see a diffuse extended envelope around the system and several new tidal features. We also get a deeper look at M51b's probable gas, which has an approximated velocity range of 560 to 740 km s$^{-1}$ and a flux of 7.5 Jy km s$^{-1}$. Compared to the VLA image, we observe more complete structures of the Southeast Tail, Northeast Cloud and Northwest Plume, as well as new features of the Northwest Cloud and Southwest Plume. M51's most prominent tidal feature, the Southeast Tail, looks very long and broad, in addition with two small detached clouds at the periphery. Due to the presence of optical and simulated counterparts, the Northwest cloud appears to be the tail of M51a, while the Northwest Plume is more likely a tidal tail of M51b. The large mass of the Northwest Plume suggests that M51b may have been as gas-rich as M51a before the interaction. In addition, the formation process of the Northeast Cloud and Southwest Plume is obscured by the lack of optical and simulated counterparts. These novel tidal features, together with M51b's probable gas, will inspire future simulations and provide a deeper understanding of the evolution of this interacting system.Comment: 11 pages, 9 figures, accepted for publication in MNRA

Enhanced treatment of shale gas fracturing waste fluid through plant-microbial synergism

Embargo until February 12, 2022Cost-efficient and environmentally friendly treatment of hydraulic fracturing effluents is of great significance for the sustainable development of shale gas exploration. We investigated the synergistic effects of plant-microbial treatment of shale gas fracturing waste fluid. The results showed that illumination wavelength and temperature are direct drivers for microbial treatment effects of CODCr and BOD5, while exhibit little effects on nitrogen compounds, TDS, EC, and SS removals as well as microbial species and composition. Plant-microbial synergism could significantly enhance the removal of pollutants compared with removal efficiency without plant enhancement. Additionally, the relative abundance and structure of microorganisms in the hydraulic fracturing effluents greatly varied with the illumination wavelength and temperature under plant-microbial synergism. 201.24 g water dropwort and 435 mg/L activated sludge with illumination of 450–495 nm (blue) at 25 °C was proved as the best treatment condition for shale gas fracturing waste fluid samples, which showed the highest removal efficiency of pollutants and the lowest algal toxicity in treated hydraulic fracturing effluents. The microbial community composition (36.73% Flavobacteriia, 25.01% Gammaproteobacteria, 18.55% Bacteroidia, 9.3% Alphaproteobacteria, 4.1% Cytophagia, and 2.83% Clostridia) was also significantly different from other treatments. The results provide a potential technical solution for improved treatment of shale gas hydraulic fracturing effluents.acceptedVersio

Increase in neuroexcitability of unmyelinated C-type vagal ganglion neurons during initial postnatal development of visceral afferent reflex functions

BACKGROUND: Baroreflex gain increase up closely to adult level during initial postnatal weeks, and any interruption within this period will increase the risk of cardiovascular problems in later of life span. We hypothesize that this short period after birth might be critical for postnatal development of vagal ganglion neurons (VGNs). METHODS: To evaluate neuroexcitability evidenced by discharge profiles and coordinate changes, ion currents were collected from identified A- and C-type VGNs at different developmental stages using whole-cell patch clamping. RESULTS: C-type VGNs underwent significant age-dependent transition from single action potential (AP) to repetitive discharge. The coordinate changes between TTX-S and TTX-R Na(+) currents were also confirmed and well simulated by computer modeling. Although 4-AP or iberiotoxin age dependently increased firing frequency, AP duration was prolonged in an opposite fashion, which paralleled well with postnatal changes in 4-AP- and iberiotoxin-sensitive K(+) current activity, whereas less developmental changes were verified in A-types. CONCLUSION: These data demonstrate for the first time that the neuroexcitability of C-type VGNs increases significantly compared with A-types within initial postnatal weeks evidenced by AP discharge profiles and coordinate ion channel changes, which explain, at least in part, that initial postnatal weeks may be crucial for ontogenesis in visceral afferent reflex function

PACIAE 2.0: An updated parton and hadron cascade model (program) for the relativistic nuclear collisions

We have updated the parton and hadron cascade model PACIAE for the relativistic nuclear collisions, from based on JETSET 6.4 and PYTHIA 5.7 to based on PYTHIA 6.4, and renamed as PACIAE 2.0. The main physics concerning the stages of the parton initiation, parton rescattering, hadronization, and hadron rescattering were discussed. The structures of the programs were briefly explained. In addition, some calculated examples were compared with the experimental data. It turns out that this model (program) works well.Comment: 23 pages, 7 figure

Pholidota chinensis alleviates azoxymethane/dextran sulfate sodium-induced colorectal carcinogenesis through inhibition of TLR4 and COX-2

Background: Inflammatory bowel disease (IBD) always progresses to colorectal cancer (CRC) which is the second most frequent cause of death by cancer. It is about 2% of population in the lifetime worldwide who at the risk for development of CRC. Oxaliplatin is an effective anticancer drug used for the treatment of advanced CRC; however, it always causes a robust painful neuropathy. Pholidota chinensis is a Chinese folk herbal medicine which was used for treatment of inflammation such as gastroenteritis, duodenal ulcer and bronchitis.Materials and Methods: The azoxymethane (AOM) and dextran sulfate sodium (DSS) were used to induce the colon tumor of mice. The effect of Pholidota chinensis on colon tumorigenesis was evaluated. Immunohistochemistry and semi-quantitative RT-PCR were used to detect the expression of toll-like receptor 4 (TLR4) and cyclooxygenase-2 (COX-2) in colon.Results: Pholidota chinensis can alleviate the colon tumorigenesis. The prevention effects of Pholidota chinensis are similar to oxaliplatin. Specifically, administration of Pholidota chinensis solution suppresses the expression of the proliferating cell nuclear antigen (PCNA), toll-like receptor 4 (TLR4) and cyclooxygenase-2 (COX-2).Conclusion: Our findings suggested that Pholidota chinensis participate in the regulation of colon cancer development through inhibiting the expression of TLR4 and COX-2.Keywords: Pholidota chinensis; colorectal cancer; Toll-like receptor 4; Cyclooxygenase-