31 research outputs found
Pengaruh Harga Terhadap Peningkatan Penjualan Produk Semen Tiga Roda Pada PT. Robcaga Beo Kabupaten Kepulauan Talaud
The development in business world these days is market by the competition between the business company is getting fierce. Especially in managing the company business unit. It is shown by the appearance of a company that offer a good quality product with a compete price on the market. To handle the fierce competition on the market then one from so many effort that the company do is by apply the strategic price. Which on the way of applying that strategi the company try to set a price that can be compete in the market so the increase sale of the product become maximum. With right price and controlled will result the domino effect to a company to build long term relationship with costumer so it can increase the sales volume. This research is a descriptive quantitative research by using the correlation approach and simple regression. To see relation between variable and to measure the impact to the variable itself. So the purpose of this research is to know how far the price effect and to the increase of PT. ROBCAGA in Talaud. According to the sesult of the research, can be shown as following: price has a correlation and significant determination effort to the increase sale of PT. ROBCAGA Talaud. According to the data analysis, coefficient value moment r = 0,685. That show there is a positive relation, and can be categorize as high and strong, also price coefficient determination to the increase sale is by 46,5% and 53,5% by the rest of it depends on the unknown factors that not been analyze in this research
Recommended from our members
Sequential Xanthalation and O‑Trifluoromethylation of Phenols: A Procedure for the Synthesis of Aryl Trifluoromethyl Ethers
Molecules containing trifluoromethoxyaryl groups are of interest in pharmaceutical, agrochemical, and materials science research, due to their unique physical and electronic properties. Many of the known methods to synthesize aryl trifluoromethyl ethers require harsh reagents and highly controlled reaction conditions and rarely occur when heteroaromatic units are present. The two-step O-trifluoromethylation of phenols via aryl xanthates is one such method that suffers from these drawbacks. Herein, we report a method for the synthesis of aryl trifluoromethyl ethers from phenols by the facile conversion of the phenol to the corresponding aryl and heteroaryl xanthates with newly synthesized imidazolium methylthiocarbonothioyl salts and conversion of these xanthates to the trifluoromethyl ethers under mild reaction conditions
Expedient Synthesis of N1-Substituted Triazole Peptidomimetics
A general
procedure for the rapid diversification of peptide scaffolds
is described. A one-pot click reaction between a peptide-alkyne and
a series of in situ generated aryl/alkyl azides affords novel N1-substituted
triazole peptidomimetics. This transformation is of broad scope, operates
under mild conditions, and is parallel chemical synthesis compatible
Synthesis and biological evaluation of manzamine analogues
The synthesis and biological evaluation of a series of analogues of manzamine A, representing partial structures of the pentacyclic ABCDE diamine core, is described. All new compounds were screened against Plasmodium falciparum and demonstrated attenuated antimalarial activity relative to that of manzamine A. © 2006 American Chemical Society
Structure and inhibitor binding characterization of oncogenic MLLT1 mutants
Dysfunction of YEATS-domain-containing MLLT1, an acetyl/acyl-lysine dependent epigenetic reader domain, has been implicated in the development of aggressive cancers. Mutations in the YEATS domain have been recently reported as a cause of MLLT1 aberrant reader function. However, structural basis for the reported alterations in affinity for acetyled/acylated histone has remained elusive. Here, we report the crystal structures of both insertion and substitution present in cancer, revealing significant conformational changes of the YEATS-domain loop 8. Structural comparison demonstrates that such alteration not only altered the binding interface for acetylated/acylated histones, but the sequence alterations in the T1 loop may enable dimeric assembly consistent inducing self-association behavior. Nevertheless, we show that also the MLLT1 mutants can be targeted by developed acetyllysine mimetic inhibitors with affinities similarly to wild type. Our report provides a structural basis for the altered behaviors and potential strategy for targeting oncogenic MLLT1 mutants
Synthesis of Pyridazine-Based α‑Helix Mimetics
A versatile
synthesis of pyridazine-based small molecule α-helix
mimetics (<b>A</b>) is presented. Modular C–C, C–N,
and C–O bond-forming reactions allow for the inclusion of a
variety of aliphatic, basic, aromatic, and heteroaromatic side chain
moieties. This robust synthesis is suitable for the preparation of
small pyridazine-based libraries
Preparation of Heteroaryl Ethers from Azine <i>N</i>‑Oxides and Alcohols
The
heteroaryl ether is an important structural feature in molecules
of biological interest, yet it remains a challenge to synthesize.
A new and practical method for the synthesis of heteroaryl ethers
is reported. In the presence of PyBroP, a variety of nonaromatic alcohols
readily add to azine <i>N</i>-oxides to afford the corresponding
heteroaryl ethers. The reaction conditions are mild, economical, chemoselective,
and compatible with a broad range of substrates. Thirty-eight examples
are provided, as is a discussion of reaction optimization and mechanism
Expedient Synthesis of α‑Heteroaryl Piperidines Using a Pd‑Catalyzed Suzuki Cross-Coupling–Reduction Sequence
A method
for the modular synthesis of α-heteroaryl piperidines
is reported. The two-step procedure consists of an initial Pd-catalyzed
Suzuki cross-coupling of the heteroaryl bromide with a boronate ester
derived from <i>N</i>-Boc piperidone, followed by subsequent
tetrahydropyridine reduction. Using this method, α-heteroaryl
piperidine products featuring a broad range of pharmaceutically relevant
azine and diazine substitutions have been prepared
Preparation of Azinones from (Cyclopropylmethoxy)azine Ethers
A general
and convenient procedure for the synthesis
of azinones
is presented. Cyclopropylmethanol is readily introduced onto various
azines where it functions as both a protecting group and surrogate
for hydroxyl. After acidic deprotection, under mild reaction conditions,
the corresponding azinones are formed and isolated in excellent yields.
>20 examples are included along with a discussion of reaction optimization,
scope, and mechanism