Interleukin 1 Trials in Cancer Patients: A Review of the Toxicity, Antitumor and Hematopoietic Effects

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/139898/1/onco0190.pd

Intrapulmonary interleukin 1 mediates acute immune complex alveolitis in the rat

Interleukin 1[alpha] and [beta] are polypeptide cytokines that possesses a wide variety of immunologic and inflammatory activities. We have examined the role of intrapulmonary interleukin 1 in the pathogenesis of acute IgG immune complex alveolitis in the rat. Intratracheal instillation of IgG anti-bovine serum albumin accompanied by intravenous infusion of bovine albumin results in acute neutrophil and complement-dependent alveolitis. Over the course of evolving lung injury there was a 12-fold increase in bronchoalveolar lavage fluid interleukin 1 activity. Intratracheal instillation of neutralizing anti-interleukin 1[beta] antibodies upon induction of lung injury resulted in a dose-dependent reduction in lung injury as assessed by measurements of pulmonary hemorrhage and vascular permeability. Morphometric analysis and measurements of myeloperoxidase activities in whole lung homogenates from rats that received anti-interleukin 1[beta] revealed a pronounced reduction in neutrophil recruitment compared to positive controls. Incubation of isolated alveolar macrophages with preformed IgG immune complexes resulted in dose-dependent interleukin 1 secretion. These data suggest that intrapulmonary IL-1 activity plays a role in neutrophil recruitment and is necessary for the full development of acute IgG immune complex induced lung injury in the rat.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/29418/1/0000494.pd

The Impact of Stress Ball Density on the Categorization of Sexual Orientation, Race and the Level of Certainty in College Students

Participants (N=67) were asked to squeeze a hard (N=34) or soft (N=33) stress ball in their non-dominant while completing an online demographic and categorization survey. It was found that Caucasian participants in the soft stress ball condition were more likely to label the androgynous face as gay than the Caucasian participants in the hard stress ball condition. It was also found that there was an own-race preference for the biracial female face. Both African American and Caucasian participants were more likely to label the biracial male face as Black, but African American participants felt more certain in this decision than Caucasian participants. Participant sex was also found to influence categorization. Male participants were more likely to label the androgynous face as straight and the biracial male as White, and females were more likely to label the androgynous face as gay and the biracial male as Black. Implications will be discussed

INSULIN GENE EXPRESSION: CELL-FREE SYNTHESIS OF PREPROINSULIN.

Abstract not availabl