MUSCAT-Assay法の個別化医療への応用

免疫系が排除すべき異常な細胞を排除できなくなると「発がん」し、守るべき自己細胞を誤って攻撃して「自己免疫疾患」となる。我々はこの免疫監視の状態を反映するバイオマーカーとして自己抗体に注目している。医療現場でごく微量の血液から網羅的に自己抗体を迅速に定量評価するためには、全長・水溶性抗原の調整技術が鍵となる。個別化医療の対応を目指して我々が開発中の自己抗体の迅速測定システムの概要についてご紹介したい

On the March of the Cerebellar Epi­leptic Convlsion in Dogs

1) Cerebellar convulsion was identical with the cerebral cortical epileptic convulsion and the number of cases in which the march of spasm was observed were quite the same as that of cases in which convulsion occurred at the same time on the whole body. 2) No convulsion occurred by stimulation of the vermis cerebellaris and also convulsions occurred very rarely by that of the cerebellar nuclei. 3) In cases having the march of spasm caused by stimulation of the lobus lunatus anterior, spasm began in the fore limb, while by stimulation of the lobus lunatus inferior and lobus semilunaris spasm started mainly in the hind limb on the side of stimulation. 4) In the case of stimulation of cerebellum, the pathway of the impulse to the opposite side was considered to be the communication between both cerebellar hemispheres and both thalami and thus the march of spasm spread from one side of the body to the other side. 5) No march of cerebellar epileptic convulsion occurred without the cerebral motor cortex. 6) After the removal of both sides of the cerebral motor cortex no march occurred, but the general convulsion occurred. 7) No convulsion occurred by stimulation of the cerebellar hemisphere after the removal of both thalami or both nuclei lenticulares. 8) The march of convulsion occurs by close cooperation of the pyramidal and extrapyramidal tracts. It seems that for the impulse of the convulsion the extrapyramidal tract plays an important role, while for the start of the convulsion, that is, march of spasm pyramidal tract plays the main role.</p

On the Adversive Movement of Area 4C of the Motor Cortex

1. Adversive movements were induced by electrical stimulation and metrazol injection on area 4c of the cerebral cortex. 2. The adversive movement from area 4c does not pass through the thalamus, nucleus caudatus, nucleus lenticularis or superior collicuIus, but through direct efferent pathways in the internal capsule. 3. The adversive movement from area 4c passes through the pyramidal tract.</p