A differentiated approach to the management of patients with hyperplastic diseases of the uterus complicated by abnormal uterine bleeding

The purpose: to justify a differentiated approach to the management of patients with hyperplastic uterine diseases complicated by abnormal uterine bleeding (AUB) based on the study of the morpho-functional features of the endo- and myometrium. It has been shown that PgR expression is low in patients with combined lesions of the endometrium and myometrium complicated by AMC. The degree of PgR expression has a strong negative correlation with pathological changes of the endometrial-myometrial junction (r=-0.71), which made it possible to consider these criteria in the creation of a differentiated algorithm for the management of patients taking into account clinical and morphological pathogenetic variants of the disease. The use of differentiated approaches to the treatment of patients with combined hyperplastic processes of the uterus, taking into account the clinical and morphological features of the disease, made it possible to reduce the number of recurrences of AMC and achieve a long-term clinical effect in comparison with traditional treatment

ДИФФЕРЕНЦИРОВАННЫЙ ПОДХОД КАК ФАКТОР РАЗВИТИЯ ПРОФЕССИОНАЛЬНО-КОММУНИКАТИВНОЙ КОМПЕТЕНЦИИ СТУДЕНТОВ

Dynamically developing world has caused fundamental changes in the field of education, so there come new trends in the implementation of traditional approaches and new aspects in education sphere, in particular in the context of the formation of educational strategies in solving urgent problems of creative realization of students’ personal potential. The relevance of the implementation of the differentiated approach within the educational system in the modernization of Russian education at the present stage is explained by the fact that it makes it possible, on the one hand, to adapt the educational system to the levels of training, students’ individual characteristics and interests, on the other hand – to formulate a desire for self-education, development of the professional competence of future specialists. The differentiated approach in higher education is aimed at overcoming the contradictions between the level of requirements in educational and professional activities and the real possibilities of each student. The implementation of this approach involves updating the content and professional components, taking into account the characteristics of each student these are individual, age and professional. The main purpose of the study was to determine the efficient criteria and indicators on the implementation of the differentiated approach to students that is to their communicative competence, knowledge of foreign language professional terminology, orientation in cognitive professional and communicative values and the nature of a person’s focus on these values. The results of the study showed that in the process of students professional education the differentiated approach performs the following functions: it is a means of development of an individual personality and future student’s creative potential; it affects the personal and professional adaptation of a future student in society; it contributes to the effective formation of conditions for resourceful professional self-realization of a future student.El desarrollo dinámico del mundo ha provocado cambios fundamentales en el campo de la educación, por lo que surgen nuevas tendencias en la implementación de enfoques tradicionales y nuevos aspectos en el ámbito de la educación, en particular en el contexto de la formación de estrategias educativas para resolver los problemas urgentes de la realización creativa de El potencial personal de los estudiantes. La relevancia de la implementación del enfoque diferenciado dentro del sistema educativo en la modernización de la educación rusa en la etapa actual se explica por el hecho de que hace posible, por un lado, adaptar el sistema educativo a los niveles de capacitación, Las características e intereses individuales de los estudiantes, por otro lado, para formular un deseo de autoeducación, el desarrollo de la competencia profesional de futuros especialistas. El enfoque diferenciado en la educación superior tiene como objetivo superar las contradicciones entre el nivel de requisitos en las actividades educativas y profesionales y las posibilidades reales de cada estudiante. La implementación de este enfoque implica actualizar el contenido y los componentes profesionales, teniendo en cuenta las características de cada estudiante: individual, de edad y profesional. El objetivo principal del estudio fue determinar los criterios e indicadores eficientes sobre la implementación del enfoque diferenciado para los estudiantes, es decir, su competencia comunicativa, el conocimiento de la terminología profesional en idiomas extranjeros, la orientación en los valores cognitivos profesionales y comunicativos y la naturaleza de la persona. centrarse en estos valores. Los resultados del estudio mostraron que en el proceso de educación profesional de los estudiantes, el enfoque diferenciado realiza las siguientes funciones: es un medio de desarrollo de una personalidad individual y el potencial creativo del futuro estudiante; Afecta la adaptación personal y profesional de un futuro alumno de la sociedad; contribuye a la formación efectiva de condiciones para la autorrealización profesional ingeniosa de un futuro estudiante.Динамично развивающийся мир вызвал кардинальные изменения в сфере образования, в связи с чем появились новые тенденции в осуществлении традиционных подходов и возникли новые аспекты, в частности в контексте формирования образовательных стратегий в решении насущных задач творческой реализации личностного потенциала студентов. Актуальность реализации дифференцированного подхода образовательной системы в условиях модернизации российского образования на современном этапе объясняется тем, что она дает возможность, с одной стороны, адаптировать образовательную систему к уровням подготовки, индивидуальным особенностям студентов, их интересам, а с другой стороны – сформулировать стремление к самообразованию, развитию профессиональной компетенции будущих специалистов. Дифференцированный подход в высшем образовании направлен на преодоление противоречий между уровнем требований в учебно-профессиональной деятельности и реальными возможностями каждого студента. Осуществление названного подхода предполагает обновление содержательного и профессионального компонентов с учетом особенностей каждого студента: индивидуальных, возрастных, профессиональных. Основная цель исследования состояла в определении критериев и показателей результативности в осуществлении дифференцированного подхода к студентам: коммуникативная компетенция, владение иноязычной профессиональной терминологией, ориентация в познавательных профессионально-коммуникативных ценностях, характер направленности личности на профессионально-коммуникативные ценности. Результаты исследования показали, что в процессе профессионального образования студентов дифференцированный подход выполняет следующие функции: является средством развития индивидуальной личности и развития творческого потенциала будущего студента; оказывает воздействие на личностную и профессиональную адаптацию будущего студента в обществе; способствует эффективному созданию условия для творческой профессиональной самореализации будущего студента

The use of microarrays for the identification of the origin of genes of avian influenza viruses in wild birds

Forty-two strains of avian influenza viruses were isolated from the wild waterfowls’ feces in the city of Moscow. These viruses, as well as reference strains and some experimental reassortants, were analyzed by microarrays. The microarrays contained 176 probes to the different segments of influenza virus genome. The microarray helps to determine 1) the hemagglutinin and neuraminidase proteins subtype; 2) the primary structure of the C-terminal sequence of the viral NS1 protein, which serves as a ligand for the PDZ domain; 3) the presence of stop codons in the reading frame of PB1-F2 as well as the N66S substitution in the PB1-F2 viral protein; 4) the presence of the polybasic site for hemagglutinin cleavage. The viruses of the H3N1, H3N6, H3N8, H4N6, H1N1, H5N3, and H11N9 subtypes were identified from the group of wild birds’ isolates. All isolates contained the ESEV sequence at the C-terminus of the NS1 protein and the full-length reading frame for the PB1-F2 protein. The replacement of N66S in PB1-F2 was found in six strains. However, the presence of the ESEV sequence (ligand of PDZ domain) in the NS1 virus protein and the N66S substitution in PB1-F2 did not lead to the pathogenicity of these viruses for mice. All isolates demonstrated high yield growth in chicken embryos and were infectious and immunogenic for mice, but did not induce any clinical symptoms.Forty-two strains of avian influenza viruses were isolated from the wild waterfowls’ feces in the city of Moscow. These viruses, as well as reference strains and some experimental reassortants, were analyzed by microarrays. The microarrays contained 176 probes to the different segments of influenza virus genome. The microarray helps to determine 1) the hemagglutinin and neuraminidase proteins subtype; 2) the primary structure of the C-terminal sequence of the viral NS1 protein, which serves as a ligand for the PDZ domain; 3) the presence of stop codons in the reading frame of PB1-F2 as well as the N66S substitution in the PB1-F2 viral protein; 4) the presence of the polybasic site for hemagglutinin cleavage. The viruses of the H3N1, H3N6, H3N8, H4N6, H1N1, H5N3, and H11N9 subtypes were identified from the group of wild birds’ isolates. All isolates contained the ESEV sequence at the C-terminus of the NS1 protein and the full-length reading frame for the PB1-F2 protein. The replacement of N66S in PB1-F2 was found in six strains. However, the presence of the ESEV sequence (ligand of PDZ domain) in the NS1 virus protein and the N66S substitution in PB1-F2 did not lead to the pathogenicity of these viruses for mice. All isolates demonstrated high yield growth in chicken embryos and were infectious and immunogenic for mice, but did not induce any clinical symptoms

РОЛЬ ПОРУШЕНЬ ЛІПІДНОГО ОБМІНУ У ВИНИКНЕННІ АНОМАЛЬНИХ МАТКОВИХ КРОВОТЕЧ У ЖІНОК РЕПРОДУКТИВНОГО ВІКУ

The aim of the study – to assess the effect of lipid metabolism disorders on the risk of abnormal uterine bleeding in women of reproductive age. Materials and Methods. Thirty women of reproductive age with abnormal uterine bleeding were examined. The expression of α-receptors for estrogen ER1, receptors for progesterone PgR and nuclear protein Ki-67 in the glands and stroma of the endometrium was performed by immunohistochemical method. Lipidogram parameters were evaluated, body mass index was determined, and anthropometry was performed. Results and Discussion. When assessing nutritional status, the prevalence among patients of BMI> 25 kg/m2 was found to be 96.7 %, while signs of nutritional constitutional obesity were 33.3 %. The average BMI was (29.1±1.6) kg/m2. The expression of estrogen receptors ER1 was higher in the glands (Me (25 %; 75 %) = 100 (80; 100) than in the stroma (Me (25 %; 75 %) = 80 (60; 90). On the other hand, the number of cells with a positive reaction to PgR progesterone receptors in the stroma and glands did not practically differ in Me (25 %; 75 %) = 80 (50, 90). The expression of Ki-67 protein was higher in glands – (ME (25 %; 75 %) =  90 (70; 100), in the stroma it did not exceed 50 % ((Me (25 %; 75 %) = 40 (30; 50). Conclusions. 1. In patients with abnormal uterine bleeding, lipid disturbances in the form of type 2b dyslipidemia are often found. 2. The severity of dyslipidemia correlates with the intensity of abnormal uterine bleedings and the expression of proliferation markers.Цель исследования – оценка влияния нарушений липидного обмена на риск возникновения аномальных маточных кровотечений у женщин репродуктивного возраста. Материалы и методы. Обследовано 30 женщин репродуктивного возраста с аномальными маточными кровотечениями. Проводили анализ экспрессии α-рецепторов к эстрогенам ER1, рецепторов к прогестерону PgR и ядерному белку Ki-67 в железах и строме эндометрия иммуногистохимическим методом. Оценивали показатели липидограммы, определяли индекс массы тела, проводили антропометрию. Результаты исследования и их обсуждение. При оценке алиментарного статуса установлено преобладание среди пациенток лиц с ИМТ>25 кг/м2 – 96,7 %, при этом признаки алиментарно-конституционального ожирения были у 33,3 %. Среднее значение ИМТ составили (29,1±1,6) кг/м2. Экспрессия рецепторов к эстрогену ER1 была более высокой в железах (Ме (25 %; 75 %) = 100 (80; 100), чем в строме (Ме (25 %; 75 %) = 80 (60; 90). Количество клеток с положительной реакцией на рецепторы к прогестерону PgR в строме и железах практически не отличалось Мe (25 %; 75 %) = 80 (50, 90). Экспрессия белка Кi-67 была выше в железах – (Мe (25 %; 75 %) = 90 (70; 100), в строме она не превышала 50 % (Мe (25 %;  75 %) = 40 (30; 50). Выводы. 1. У пациенток с аномальными маточными кровотечениями часто встречаются нарушения липидного обмена в виде дислипидемии 2b типа. 2. Выраженность дислипидемии коррелирует с интенсивностью АМК и экспрессией маркеров пролиферации.Мета дослідження – оцінка впливу порушень ліпідного обміну на ризик виникнення аномальних маткових кровотеч у жінок репродуктивного віку. Матеріали та методи. Обстежено 30 жінок репродуктивного віку з аномальними матковими кровотечами. Проводили аналіз експресії α-рецепторів до естрогенів ER1, рецепторів до прогестерону PgR та ядерного білка Ki-67 у залозах та стромі ендометрія імуногістохімічним методом. Оцінювали показники ліпідограми, визначали індекс маси тіла, проводили антропометрію. Результати дослідження та їх обговорення. При оцінці аліментарного статусу встановлено переважання серед пацієнток осіб з ІМТ>25 кг/м2 – 96,7 %, при цьому ознаки аліментарно-конституційного ожиріння були у 33,3 %. Середні значення ІМТ склали (29,1±1,6) кг/м2. Експресія рецепторів до естрогену ER1 була більш високою у залозах (Ме (25 %;75 %) =  100 (80; 100), аніж у стромі (Ме (25 %;75 %) = 80 (60; 90). Натомість, кількість клітин із позитивною реакцією на рецептори до прогестерону PgR у стромі та залозах майже не відрізнялася – Ме (25 %;75 %) = 80 (50; 90). Експресія білка Кі-67 була вищою у залозах – (Ме (25 %;75 %) = 90 (70; 100), у стромі вона не перевищувала 50 % (Ме (25 %;75 %) = 40 (30; 50). Висновки. 1. У пацієнток з аномальними матковими кровотечами часто зустрічаються порушення ліпідного обміну у вигляді дисліпідемії 2b типу. 2. Вираження дисліпідемії корелює з інтенсивністю АМК та експресією маркерів проліферації

Spin and orbital mechanisms of the magneto-gyrotropic photogalvanic effects in GaAs/AlGaAs quantum well structures

We report on the study of the linear and circular magneto-gyrotropic photogalvanic effect (MPGE) in GaAs/AlGaAs quantum well structures. Using the fact that in such structures the Land\'e-factor g* depends on the quantum well (QW) width and has different signs for narrow and wide QWs, we succeeded to separate spin and orbital contributions to both MPGEs. Our experiments show that, for most quantum well widths, the PGEs are mainly driven by spin-related mechanisms, which results in a photocurrent proportional to the g* factor. In structures with a vanishingly small g* factor, however, linear and circular MPGE are also detected, proving the existence of orbital mechanisms.Comment: 10 pages, 10 figure

On the minima and convexity of Epstein Zeta function

Let $Z_n(s; a_1,..., a_n)$ be the Epstein zeta function defined as the meromorphic continuation of the function \sum_{k\in\Z^n\setminus\{0\}}(\sum_{i=1}^n [a_i k_i]^2)^{-s}, \text{Re} s>\frac{n}{2} to the complex plane. We show that for fixed $s\neq n/2$, the function $Z_n(s; a_1,..., a_n)$, as a function of $(a_1,..., a_n)\in (\R^+)^n$ with fixed $\prod_{i=1}^n a_i$, has a unique minimum at the point $a_1=...=a_n$. When $\sum_{i=1}^n c_i$ is fixed, the function $$(c_1,..., c_n)\mapsto Z_n(s; e^{c_1},..., e^{c_n})$$ can be shown to be a convex function of any $(n-1)$ of the variables $\{c_1,...,c_n\}$. These results are then applied to the study of the sign of $Z_n(s; a_1,..., a_n)$ when $s$ is in the critical range $(0, n/2)$. It is shown that when $1\leq n\leq 9$, $Z_n(s; a_1,..., a_n)$ as a function of $(a_1,..., a_n)\in (\R^+)^n$, can be both positive and negative for every $s\in (0,n/2)$. When $n\geq 10$, there are some open subsets $I_{n,+}$ of $s\in(0,n/2)$, where $Z_{n}(s; a_1,..., a_n)$ is positive for all $(a_1,..., a_n)\in(\R^+)^n$. By regarding $Z_n(s; a_1,..., a_n)$ as a function of $s$, we find that when $n\geq 10$, the generalized Riemann hypothesis is false for all $(a_1,...,a_n)$.Comment: 27 page

Composition and distribution of the peracarid crustacean fauna along a latitudinal transect off Victoria Land (Ross Sea, Antarctica) with special emphasis on the Cumacea

The following study was the first to describe composition and structure of the peracarid fauna systematically along a latitudinal transect off Victoria Land (Ross Sea, Antarctica). During the 19th Antarctic expedition of the Italian research vessel “Italica” in February 2004, macrobenthic samples were collected by means of a Rauschert dredge with a mesh size of 500 m at depths between 85 and 515 m. The composition of peracarid crustaceans, especially Cumacea was investigated. Peracarida contributed 63% to the total abundance of the fauna. The peracarid samples were dominated by amphipods (66%), whereas cumaceans were represented with 7%. Previously, only 13 cumacean species were known, now the number of species recorded from the Ross Sea increased to 34. Thus, the cumacean fauna of the Ross Sea, which was regarded as the poorest in terms of species richness, has to be considered as equivalent to that of other high Antarctic areas. Most important cumacean families concerning abundance and species richness were Leuconidae, Nannastacidae, and Diastylidae. Cumacean diversity was lowest at the northernmost area (Cape Adare). At the area off Coulman Island, which is characterized by muddy sediment, diversity was highest. Diversity and species number were higher at the deeper stations and abundance increased with latitude. A review of the bathymetric distribution of the Cumacea from the Ross Sea reveals that most species distribute across the Antarctic continental shelf and slope. So far, only few deep-sea records justify the assumption of a shallow-water–deep-sea relationship in some species of Ross Sea Cumacea, which is discussed from an evolutionary point of view

Experience of the successful treatment with canakinumab of a patient with NLPC4-associated autoinflammatory syndrome with enterocolitis

The article shows the observation of rare NLPC4-associated autoinflammatory syndrome with enterocolitis and familial cold urticaria. Diagnosis is confirmed molecularly-genetically: previously not described mutation c.928C>T in the heterozygous state in NLRC4 gene is discovered by a method of the new generation sequencing. The use of a monoclonal antibody to the interleukin 1 canakinumab provided complete relief of fever and skin and intestinal symptoms in just 1 week of treatment. Later the signs of inflammation have disappeared completely; the patient’s quality of life improved and life-threatening complications were prevented. The above example demonstrates the high clinical efficacy of canakinumab in the patient with NLRC4-associated autoinflammatory syndrome and suggests promising therapeutic use of interleukin 1 blockers in such patients. There were no adverse events during canakinumab therapy

High Efficiency of Kanakinumabum for a Patient with a Late Diagnosed Chronic Infantile Neurological Cutaneous Articular Syndrome (CINCA)

The article presents the monitoring of a severe course of CINCA/NOMID syndrome diagnosed at late stages. The use of monoclonal antibodies to IL 1 — kanakinumabum — in a patient with chronic neurological cutaneous and articular syndrome was successful: fever, cutaneous and pain syndromes were completely stopped, joint contractures decreased after one week of therapy. Laboratory parameters of the child’s disease activity (ESR and CRP) became normal after 8 weeks of treatment. Movements in the affected joints recovered completely after 24 weeks; the audiologist noted an improvement in hearing. The above clinical example demonstrates the high efficiency of kanakinumabum for a patient with chronic neurological cutaneous and articular syndrome, and shows the perspective of therapeutic application of IL 1 blocker for patients with CINCA syndrome including advanced stages of the disease. No adverse effects were noted during kanakinumabum therapy

Клинический случай применения тоцилизумаба у пациента с системным ювенильным идиопатическим артритом

This article describes a case of successfully used tocilizumab (interleukin 6 receptors monoclonal antibodies) in a two-year patient with severe systemic juvenile idiopathic arthritis resistant to oral and parenteral glucocorticoids, nonsteroidal anti-inflammatory drugs, and methotrexate. Just after the first injection of tocilizumab, fever and pain ceased, morning stiffness decreased significantly; laboratory disease activity indices normalized by the 4th week of drug use; by the 16th week inflammatory changes in the joints regressed completely, the disease entered its inactive phase. After using tocilizumab, remission duration was 20 months for articular syndrome and systemic manifestations. No adverse reactions have been registered.В статье описан случай успешного применения моноклональных антител к рецепторам интерлейкина 6 тоцилизумаба у двухлетнего пациента с тяжелым течением системного ювенильного идиопатического артрита, резистентного к пероральным и парентеральным глюкокортикостероидам, нестероидным противовоспалительным препаратам, метотрексату. Уже после первого введения тоцилизумаба купировались лихорадка и болевой синдром, значительно уменьшилась утренняя скованность, к 4-й нед введения препарата нормализовались лабораторные показатели активности болезни, к 16-й нед полностью регрессировали воспалительные изменения в суставах, была констатирована фаза неактивной болезни. Длительность ремиссии суставного синдрома и системных проявлений после применения тоцилизумаба составила 20 мес. Нежелательных реакций на фоне проводимой терапии не зарегистрировано