The effect of humoral factors released by hypoperfused placenta on fetal development

Simulation of hypoperfusion of the right uterine horn in rats on the 14th day of pregnancy resulted in disruption of microcirculation in placentas of the left uterine horn, decrease of fetal weight and length as well as in fetal death after implantation. The obtained data complement the overall understanding of the pathogenesis of preeclampsia and placental insufficiency and create preconditions for development of new areas of creation of effective drugs for treatment and prevention of these pathologie

The effect of arginase ii selective inhibitors on the functional parameters of experimental animals in ADMA–like preeclampsia

Perinatal mortality rate and the rate of preterm birth (10-12%) in pregnant women with hypertensive disorders far outweigh the corresponding values in women with physiological pregnancy. Despite such close attention worldwide to this problem, today the number of this complication has no tendency to decreas

Integrated evaluation of the endothelioprotective activity of an innovative peptide simulating the alpha-helix of B-erythropoethin in L-name-induced nitrogen oxide deficiency at the late gestation period

To study the efficiency of using carbamylated darbepoetin, asialized erythropoietin and an 11-amino acid peptide that simulating the spatial structure of the B-erythropoietin alpha-helix in the correction of L-NAME-induced nitric oxide deficiency in the late gestation perio

Correction of morphofunctional disorders of the cardiovascular system with asialized erythropoietin and arginase II selective inhibitors KUD 974 and KUD 259 in experimental preeclampsia

The aim of the present study was to study the effectiveness of asialized erythropoietin and arginase II selective inhibitors: KUD-259 and KUD-974 in the correction of morphofunctional disorders of the cardiovascular system in experimental preeclampsi

The effect of humoral factors released by hypoperfused placenta on fetal development

Simulation of hypoperfusion of the right uterine horn in rats on the 14th day of pregnancy resulted in disruption of microcirculation in placentas of the left uterine horn, decrease of fetal weight and length as well as in fetal death after implantation. The obtained data complement the overall understanding of the pathogenesis of preeclampsia and placental insufficiency and create preconditions for development of new areas of creation of effective drugs for treatment and prevention of these pathologie

Biological mechanisms of natural cytoprotection - a promising trend in the development of new medicines aimed at prevention and treatment of preeclampsia

Preeclampsia is a frequent and dangerous disease in pregnancy which has shown no decrease in incidence. The article describes preeclampsia pathogenesis as reported in recent studies. A promising trend in the development of new medicines aimed at prevention and treatment of preeclampsia is the activation of biological processes of cytoprotection which arise during ischemic preconditioning. The article cites experimental and clinical data that help to justify the good potential of this area of research

Chlorobenzene hydrodechlorination on bimetallic catalysts prepared by laser electrodispersion of NiPd alloy

NiPd bimetallic systems were for the first time synthesized by laser electrodispersion (LED) of the Ni 77 Pd 23 alloy target followed by the deposition of produced bimetallic particles on a TEM copper grid and alumina granules. Selective area energy-dispersive analysis confirms the bimetallic nature of NiPd particles deposited on a TEM copper grid. Their mean size is 1.0 nm according to TEM. XPS data demonstrate that under deposition on alumina granules (total metal content of 0.005 wt.%), nickel in bimetallic particles nearly completely oxidizes to Ni 2+ species predominantly in the form of aluminate. At the same time major part of palladium (84%) exists in Pd 0 but oxidizes to Pd 2+ (80%) during 6 months storage in air. Both metals are deposited on the external surface of alumina granules and localized in the same areas. In situ reduction of both metals by H 2 in the catalytic cell of XPS spectrometer is hindered. Nickel is not reduced even at 450°C, confirming the formation of NiAlO x , whereas palladium is reduced at higher temperatures compared to a similar monometallic catalyst. Nevertheless, NiPd/Al 2 O 3 catalyst is more efficient in gas-phase chlorobenzene hydrodechlorination at 150-350°C than Ni/Al 2 O 3 and even Pd/Al 2 O 3 , and much more stable. The difference may be caused by the formation of new active sites due to the contact between Pd 0 and NiAlO x -modified support, and the protective action of spinel reacting with HCl by-product. © 2018 IUPAC and De Gruyter.Funding: This work was financially supported by RFBR, Funder Id: 10.13039/501100002261 (grant 16-03-00073) and in part by Institute of Metal Physics in the frame of “Magnit” Program

Биологические механизмы естественной цитопротекции - перспективное направление создания новых лекарственных препаратов для профилактики и лечения преэклампсии

Preeclampsia is a frequent and dangerous disease in pregnancy which has shown no decrease in incidence. The article describes preeclampsia pathogenesis as reported in recent studies. A promising trend in the development of new medicines aimed at prevention and treatment of preeclampsia is the activation of biological processes of cytoprotection which arise during ischemic preconditioning. The article cites experimental and clinical data that help to justify the good potential of this area of research.Преэклампсия является частым и опасным заболеванием беременных, не имеющим тенденции к снижению. В приведенной статье описывается патогенез преэклампсии в соответствии с последними исследованиями. Одним из перспективных направлений создания лекарственных препаратов для профилактики и лечения преэклампсии может быть активация биологических процессов цитопротекции, возникающих при ишемическом прекондиционировании. Приведены данные экспериментальных исследований и клинические наблюдения, которые позволяют обосновать перспективность указанного направления