A study of longitudinal oscillations of propellant tanks and wave propagations in feed lines. Part II - Wave propagation in elastic pipe filled with incompressible viscous fluid

Fluid wave propagation in liquid propellant feed syste

Juvenile Myelomonocytic Leukemia: Molecular Pathogenesis Informs Current Approaches to Therapy and Hematopoietic Cell Transplantation

Juvenile myelomonocytic leukemia (JMML) is a rare childhood leukemia that has historically been very difficult to confidently diagnose and treat. The majority of patients ultimately require allogeneic hematopoietic cell transplantation (HCT) for cure. Recent advances in the understanding of the pathogenesis of the disease now permit over 90% of patients to be molecularly characterized. Pre-HCT management of patients with JMML is currently symptom-driven. However, evaluation of potential high-risk clinical and molecular features will determine which patients could benefit from pre-HCT chemotherapy and/or local control of splenic disease. Furthermore, new techniques to quantify minimal residual disease burden will determine whether pre-HCT response to chemotherapy is beneficial for long-term disease-free survival. The optimal approach to HCT for JMML is unclear, with high relapse rates regardless of conditioning intensity. An ongoing clinical trial in the Children’s Oncology Group will test if less toxic approaches can be equally effective, thereby shifting the focus to post-HCT immunomanipulation strategies to achieve long-term disease control. Finally, our unraveling of the molecular basis of JMML is beginning to identify possible targets for selective therapeutic interventions, either pre- or post-HCT, an approach which may ultimately provide the best opportunity to improve outcomes for this aggressive disease

Vlasov Description Of Dense Quark Matter

We discuss properties of quark matter at finite baryon densities and zero temperature in a Vlasov approach. We use a screened interquark Richardson's potential consistent with the indications of Lattice QCD calculations. We analyze the choices of the quark masses and the parameters entering the potential which reproduce the binding energy (B.E.) of infinite nuclear matter. There is a transition from nuclear to quark matter at densities 5 times above normal nuclear matter density. The transition could be revealed from the determination of the position of the shifted meson masses in dense baryonic matter. A scaling form of the meson masses in dense matter is given.Comment: 15 pages 4 figure

Zone Determinant Expansions for Nuclear Lattice Simulations

We introduce a new approximation to nucleon matrix determinants that is physically motivated by chiral effective theory. The method involves breaking the lattice into spatial zones and expanding the determinant in powers of the boundary hopping parameter.Comment: 20 pages, 6 figures, revtex4 (version to appear in PRC

Precision Spectroscopy of Polarized Molecules in an Ion Trap

Polar molecules are desirable systems for quantum simulations and cold chemistry. Molecular ions are easily trapped, but a bias electric field applied to polarize them tends to accelerate them out of the trap. We present a general solution to this issue by rotating the bias field slowly enough for the molecular polarization axis to follow but rapidly enough for the ions to stay trapped. We demonstrate Ramsey spectroscopy between Stark-Zeeman sublevels in 180Hf19F+ with a coherence time of 100 ms. Frequency shifts arising from well-controlled topological (Berry) phases are used to determine magnetic g-factors. The rotating-bias-field technique may enable using trapped polar molecules for precision measurement and quantum information science, including the search for an electron electric dipole moment.Comment: Accepted to Scienc

The structure of EAS at E 0.1 EeV

The ratio of extensive air showers (EAS) total shower energy in the electromagnetic channel (E em) to the size of the shower at maximum development (N max) from a direct measurement of shower longitudinal development using the air fluorescence technique was calculated. The values are not inconsistent with values based upon track length integrals of the Gaisser-Hillas formula for shower development or the known relation between shower energy and size at maximum for pure electromagnetic cascades. Using Linsley's estimates for undetected shower energy based on an analysis of a wide variety of cosmic ray data, the following relation for total shower energy E vs N max is obtained. The Gaisser Hillas implied undetected shower energy fractions

MTHFR C677T polymorphism, homocysteine and B vitamins status in a sample of Chinese and Malay subjects in Universiti Putra Malaysia.

INTRODUCTION: Methylenetetrahydrofolate reductase (MTHFR) C677T is involved in folate and homocysteine metabolism. Disruption in the activity of this enzyme will alter their levels in the body. METHODOLOGY: This study assessed MTHFR C677T polymorphism and its relationship with serum homocysteine and B-vitamins levels in a sample of Chinese and Malays subjects in UPM, Serdang. One hundred subjects were randomly selected from among the university population. Folate, vitamin B12, B6, and homocysteine levels were determined using MBA, ECLIA, and HPLC, respectively. PCR coupled with HinfI digestion was used for detection of MTHFR C677T polymorphism. RESULTS: The frequency of T allele was higher in the Chinese subjects (0.40) compared to the Malay (0.14). Folate, vitamin B12 and B6 levels were highest in the wild genotype in both ethnic groups. Subjects with heterozygous and homozygous genotype showed the highest homocysteine levels. The serum folate and homocysteine were mainly affected by homozygous genotype. CONCLUSION: MTHFR C677T polymorphism plays an important role in influencing the folate and homocysteine metabolism