194 research outputs found
Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar
Although previously considered entirely reversible, general anaesthesia is now being viewed as a potentially significant risk to cognitive performance at both extremes of age. A large body of preclinical as well as some retrospective clinical evidence suggest that exposure to general anaesthesia could be detrimental to cognitive development in young subjects, and might also contribute to accelerated cognitive decline in the elderly. A group of experts in anaesthetic neuropharmacology and neurotoxicity convened in Salzburg, Austria for the BJA Salzburg Seminar on Anaesthetic Neurotoxicity and Neuroplasticity. This focused workshop was sponsored by the British Journal of Anaesthesia to review and critically assess currently available evidence from animal and human studies, and to consider the direction of future research. It was concluded that mounting evidence from preclinical studies reveals general anaesthetics to be powerful modulators of neuronal development and function, which could contribute to detrimental behavioural outcomes. However, definitive clinical data remain elusive. Since general anaesthesia often cannot be avoided regardless of patient age, it is important to understand the complex mechanisms and effects involved in anaesthesia-induced neurotoxicity, and to develop strategies for avoiding or limiting potential brain injury through evidence-based approache
Impact of the insulin and glucose content of the postoperative fluid on the outcome after pediatric cardiac surgery
Postoperative cognitive dysfunction after inhalational anesthesia in elderly patients undergoing major surgery: the influence of anesthetic technique, cerebral injury and systemic inflammation
Increased mitochondrial ATP production capacity in brain of healthy mice and a mouse model of isolated complex I deficiency after isoflurane anesthesia
Cardio-respiratory development in bird embryos: new insights from a venerable animal model
You, my beloved, you\u27re just like the sunrise. [first line of chorus]
Performance Medium: Piano and Voice (with lyrics
On Hollywood Shore.
Gift of Dr. Mary Jane Esplen.Piano vocal [instrumentation]On Hollywood shore there's a place I adore [first line]Soft southern breeze o'er soft southern seas [first line of chorus]F major [key]In Waltz time [tempo]Popular song ; ballad waltz [form/genre]Shore, moon, trees [illustration]To Mr. Paul D. Rhynearson [dedication]Blurb about composer on front inside cover [note]Publisher's advertisement on back cover [note
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