443 research outputs found

    In vitro culture of chicken and mouse embryo-derived cells

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    A Sampler from the New Historical Atlas of Maine: Religion in Maine

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    This article offers an example of work-in-progress on a significant project to develop an historical atlas of Maine. Although an article depicting religious settlement in Maine may seem far removed from the policy analyses typically featured in the journal, religious participation is a fundamental aspect of civic engagement in the United States. Thus, we feature here a glimpse of Maine’s religious heritage. We also present Maine Policy Review’s first full color pullout, which is intended to give readers a visual as well as textual portrait of religious settlement in the Kennebec Valley and Portland through the first half of the nineteenth century

    Editorial: learn about leadership and never stop

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    The NHS is not one organisation; it’s made up of hundreds of individual organisations, each with their own unique culture - and often sub or ‘micro’ cultures. Consider all of the teams and departments that are working together for patients and their loved ones; where would they be without effective leadership? And for those not well-led, consider where they would be if they were. Peter Homa and Claire Lodge from the NHS Leadership Academy explore why learning about leadership is one of the wisest investments you can make

    House rules: the collaborative nature of policy in domestic networks

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    We draw on ethnographic studies to understand the collaborative nature of network policies or rules in domestic settings. We outline the technical nature of network policy in enterprise domains and how this contrasts with the social or collaborative nature of rules in everyday life. We then consider the deployment of network control and policy system interfaces in domestic settings, highlighting the ways in which household members collaboratively exploited these to support network governance. Our results suggest that an important feature of network policy in domestic contexts is that rules about network activity are shaped by and answerable to the moral reasoning that governs domestic life. This reframes our understanding of how rules are oriented to and used in the home and has significant implications for the design of home network policy systems

    Long-Term Effects of Pedicle Clamping during Major Hepatectomy for Colorectal Liver Metastases

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    The use of the Pringle maneuver (PM) varies widely among surgical departments. Its use depends on the operator and type of liver resection. The aim of this study was to determine the impact of the PM on patient outcomes when undergoing major liver resections. This retrospective study comprised 179 colorectal liver metastasis patients from two liver centers from Leeds and Warsaw. Only right or right extended hepatectomies with negative oncological margins were included. The primary outcome measure was the 5-year overall survival (OS). The PM was applied during 60 (33.5%) major hepatectomies included in the study and was associated with a higher peak 3-day postoperative bilirubin concentration (p = 0.002), yet not with the peak 3-day alanine aminotransferase activity (p = 0.415). The 5-year OS after liver resections with the PM and without the PM were 55.0% and 33.4%, respectively (p = 0.019). Following stratification by the Tumor Burden Score, after resections with the use of the PM, superior survival was particularly found in the subgroup of patients at intermediate risk of recurrence (p = 0.004). However, the use of the PM had no significant effect on the 5-year overall survival following adjustment for the confounding effect of the carcinoembryonic antigen concentration (p = 0.265). The use of the PM had no negative effects on the long-term outcomes in patients undergoing major, oncologically radical liver resections for colorectal metastases

    The Problem with Big Data: Operating on Smaller Datasets to Bridge the Implementation Gap

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    Big datasets have the potential to revolutionize public health. However, there is a mismatch between the political and scientific optimism surrounding big data and the public’s perception of its benefit. We suggest a systematic and concerted emphasis on developing models derived from smaller datasets to illustrate to the public how big data can produce tangible benefits in the long term. In order to highlight the immediate value of a small data approach, we produced a proof-of-concept model predicting hospital length of stay. The results demonstrate that existing small datasets can be used to create models that generate a reasonable prediction, facilitating health-care delivery. We propose that greater attention (and funding) needs to be directed toward the utilization of existing information resources in parallel with current efforts to create and exploit “big data.

    Anomalous stress relaxation in random macromolecular networks

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    Within the framework of a simple Rouse-type model we present exact analytical results for dynamical critical behaviour on the sol side of the gelation transition. The stress-relaxation function is shown to exhibit a stretched-exponential long-time decay. The divergence of the static shear viscosity is governed by the critical exponent k=ϕ−ÎČk=\phi -\beta, where ϕ\phi is the (first) crossover exponent of random resistor networks, and ÎČ\beta is the critical exponent for the gel fraction. We also derive new results on the behaviour of normal stress coefficients.Comment: 13 pages, 6 figures; contribution to the proceedings of the Minerva International Workshop on Frontiers In The Physics Of Complex Systems (25-28 March 2001) - to appear in a special issue of Physica

    Living with interpersonal data: observability and accountability in the age of pervasive ICT

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    The Internet of Things, alongside existing mobile digital technologies, heralds a world in which pervasive sensing constantly captures data about us. Simultaneous with this technology programme are moves by policymakers to shore up the digital economy through the legislating of new trust-building models of data management. These moves seek to give individuals control and oversight of their personal data. Within shared settings, the consequences of these changes are the large-scale generation of interpersonal data generated by and acting on the group rather than individual. We consider how such systems create new forms of observability and hence accountability among members of the home, and draw on the work of Simmel and Goffman to explore how these demands are managed. Such management mitigates the more extreme possibilities for domestic monitoring posited by these systems, yet without careful design there remains a considerable danger of unanticipated negative consequences

    Biological Invasions: Recommendations for U.S. Policy and Management

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    The Ecological Society of America has evaluated current U.S. national policies and practices on biological invasions in light of current scientific knowledge. Invasions by harmful nonnative species are increasing in number and area affected; the damages to ecosystems, economic activity, and human welfare are accumulating. Without improved strategies based on recent scientific advances and increased investments to counter invasions, harm from invasive species is likely to accelerate. Federal leadership, with the cooperation of state and local governments, is required to increase the effectiveness of prevention of invasions, detect and respond quickly to new potentially harmful invasions, control and slow the spread of existing invasions, and provide a national center to ensure that these efforts are coordinated and cost effective. Specifically, the Ecological Society of America recommends that the federal government take the following six actions: (1) Use new information and practices to better manage commercial and other pathways to reduce the transport and release of potentially harmful species; (2) Adopt more quantitative procedures for risk analysis and apply them to every species proposed for importation into the country; (3) Use new cost-effective diagnostic technologies to increase active surveillance and sharing of information about invasive species so that responses to new invasions can be more rapid and effective; (4) Create new legal authority and provide emergency funding to support rapid responses to emerging invasions; (5) Provide funding and incentives for cost-effective programs to slow the spread of existing invasive species in order to protect still uninvaded ecosystems, social and industrial infrastructure, and human welfare; and (6) Establish a National Center for Invasive Species Management (under the existing National Invasive Species Council) to coordinate and lead improvements in federal, state, and international policies on invasive species. Recent scientific and technical advances provide a sound basis for more cost-effective national responses to invasive species. Greater investments in improved technology and management practices would be more than repaid by reduced damages from current and future invasive species. The Ecological Society of America is committed to assist all levels of government and provide scientific advice to improve all aspects of invasive-species management
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